Immunological Reviews

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Host responses to alphavirus infection
Immunological Reviews - Tập 225 Số 1 - Trang 27-45 - 2008
Kate D. Ryman, William B. Klimstra
Summary: Members of the Alphavirus genus are classified into New World and Old World groups based upon their disease characteristics and primary areas of endemicity. The two groups exhibit noteworthy differences in pathogenesis during human infection, with Old World viruses primarily causing febrile and arthritogenic diseases and the New W...... hiện toàn bộ
Indoleamine 2,3‐dioxygenase in T‐cell tolerance and tumoral immune escape
Immunological Reviews - Tập 222 Số 1 - Trang 206-221 - 2008
Jessica Katz, Alexander J. Muller, George C. Prendergast
Summary: Indoleamine 2, 3‐dioxygenase (IDO) degrades the essential amino acid tryptophan in mammals, catalyzing the initial and rate‐limiting step in the de novo biosynthesis nicotinamide adenine dinucleotide (NAD). Broad evidence implicates IDO and the tryptophan catabolic pathway in generation of immune tolerance to foreign antigens in t...... hiện toàn bộ
Conservation and diversification of MHC class I and its related molecules in vertebrates
Immunological Reviews - Tập 167 Số 1 - Trang 81-100 - 1999
Keiichiro Hashimoto, Kazuhiko Okamura, Hisateru Yamaguchi, Mitsuru Ototake, Teruyuki Nakanishi, Yoshikazu Kurosaiva
Summary: The elucidation of the complete peptide‐binding domains of the highly polymorphic shark MHC class I genes offered us an opportunity to examine the characteristics of their predicted protein products in the light of the latest advance m the structural studies of the MHC class I molecules. The results suggest that the fundamental ch...... hiện toàn bộ
TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity
Immunological Reviews - Tập 235 Số 1 - Trang 172-189 - 2010
Gordon J. Freeman, José M. Casasnovas, Dale T. Umetsu, Rosemarie H. DeKruyff
Summary:  The TIM (T cell/transmembrane, immunoglobulin, and mucin) gene family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity, and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of ph...... hiện toàn bộ
Inflammasomes: guardians of cytosolic sanctity
Immunological Reviews - Tập 227 Số 1 - Trang 95-105 - 2009
Mohamed Lamkanfi, Vishva M. Dixit
Summary:  The innate immune system is critical in recognizing bacterial and viral infections to evoke a proper immune response. Certain members of the intracellular nucleotide‐binding and oligomerization domain (NOD)‐like receptor (NLR) family detect microbial components in the cytosol and trigger the assembly of large caspase‐1‐activating complexes termed inflammaso...... hiện toàn bộ
Therapeutic Human Antibodies Derived from PCR Amplification of B‐Cell Variable Regions
Immunological Reviews - Tập 130 Số 1 - Trang 69-85 - 1992
James W. Larrick, Ellen F. Wallace, M J Coloma, Urs Bruderer, Aloïs B. Lang, Kirk E. Fry
Impact of Thymus on the Generation of Immunocompetence and Diversity of Antigen‐Specific MHC‐Restricted Cytotoxic T‐Lymphocyte Precursors
Immunological Reviews - Tập 58 Số 1 - Trang 95-129 - 1981
Hermann Wagner, Conny Hardt, Hubert Stockinger, Klaus Pf Izenmaier, Robert Bartlett, Martin Röllinghoff
RNA recognition and signal transduction by RIG‐I‐like receptors
Immunological Reviews - Tập 227 Số 1 - Trang 54-65 - 2009
Mitsutoshi Yoneyama, Takashi Fujita
Summary:  Viral infection is detected by cellular sensor molecules as foreign nucleic acids and initiates innate antiviral responses, including the activation of proinflammatory cytokines and type I interferon (IFN). Recent identification of cytoplasmic viral sensors, such as retinoic acid‐inducible gene‐I‐like receptors (RLRs), highlights their significance in the i...... hiện toàn bộ
Ca2+‐NFATc1 signaling is an essential axis of osteoclast differentiation
Immunological Reviews - Tập 231 Số 1 - Trang 241-256 - 2009
Takako Negishi‐Koga, Daniel Metzger
Summary:  Osteoclasts are unique, multinucleated giant cells that decalcify and degrade the bone matrix. They originate from hematopoietic cells and their differentiation is dependent on a tumor necrosis factor (TNF) family cytokine, receptor activator of nuclear factor‐κB (NF‐κB) ligand (RANKL), as well as macrophage‐colony stimulating factor (M‐CSF). Recent studies...... hiện toàn bộ
Comparative and functional genomics of the innate immune system in the malaria vector Anopheles gambiae
Immunological Reviews - Tập 198 Số 1 - Trang 127-148 - 2004
George K. Christophides, Dina Vlachou, Fotis C. Kafatos
Summary:  In much of Africa, the mosquito Anopheles gambiae is the major vector of human malaria, a devastating infectious disease caused by Plasmodium parasites. Vector and parasite interact at multiple stages and locations, and the nature and effectiveness of this reciprocal interaction determines the success of...... hiện toàn bộ
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