Genes, Brain and Behavior

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Nicotinic acetylcholine receptors: upregulation, age‐related effects and associations with drug use
Genes, Brain and Behavior - Tập 15 Số 1 - Trang 89-107 - 2016
Whitney E. Melroy-Greif, Jerry A. Stitzel, Marissa A. Ehringer
Nicotinic acetylcholine receptors are ligand‐gated ion channels that exogenously bind nicotine. Nicotine produces rewarding effects by interacting with these receptors in the brain's reward system. Unlike other receptors, chronic stimulation by an agonist induces an upregulation of receptor number that is not due to increased gene expression in adults; while upregulation also occurs during develop... hiện toàn bộ
Induction of immediate early genes in the mouse auditory cortex after auditory cued fear conditioning to complex sounds
Genes, Brain and Behavior - Tập 11 Số 3 - Trang 314-324 - 2012
Manuel Peter, Harald Scheuch, Thomas R. Burkard, Jaroslav Tinter, Tanja Wernle, Simon Rumpel
Immediate early genes (IEGs) are widely used as markers to delineate neuronal circuits because they show fast and transient expression induced by various behavioral paradigms. In this study, we investigated the expression of the IEGs c‐fos and Arc in the auditory cortex of the mouse after auditory cued fear conditioning using quantitative polymerase chain reaction and microarray analysis. To test ... hiện toàn bộ
Phenotyping mouse chromosome substitution strains reveal multiple QTLs for febrile seizure susceptibility
Genes, Brain and Behavior - Tập 8 Số 2 - Trang 248-255 - 2009
Ellen V.S. Hessel, Koen L.I. van Gassen, Inge G. Wolterink‐Donselaar, Peter J. Stienen, Cathy Fernandes, Jan H. Brakkee, Martien J. Kas, P.N.E. de Graan
Febrile seizures (FS) are the most common seizure type in children and recurrent FS are a risk factor for developing temporal lobe epilepsy. Although the mechanisms underlying FS are largely unknown, recent family, twin and animal studies indicate that genetics are important in FS susceptibility. Here, a forward genetic strategy was used employing mouse chromosome substitution strains (CSS) to ide... hiện toàn bộ
A phenotypic and molecular characterization of the fmr1‐tm1Cgr Fragile X mouse
Genes, Brain and Behavior - Tập 3 Số 6 - Trang 337-359 - 2004
Qijiang Yan, P. K. Asafo‐Adjei, H Arnold, Richard E. Brown, Robert Bauchwitz
Fragile X Syndrome is the most common form of inherited mental retardation. It is also known for having a substantial behavioral morbidity, including autistic features. In humans, Fragile X Syndrome is almost always caused by inactivation of the X‐linked FMR1 gene. A single knockout mouse model, fmr1‐tm1Cgr, exists. In this report we further characterize the cognitive and behavioral phenotype of t... hiện toàn bộ
Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model
Genes, Brain and Behavior - Tập 11 Số 5 - Trang 586-600 - 2012
Susan Goebel-Goody, E. D. Wilson‐Wallis, Sam Royston, Stephanie Tagliatela, Janice R. Naegele, Paul J. Lombroso
Fragile X syndrome (FXS), the most common inherited form of intellectual disability and prevailing known genetic basis of autism, is caused by an expansion in the Fmr1 gene that prevents transcription and translation of fragile X mental retardation protein (FMRP). FMRP binds to and controls translation of mRNAs downstream of metabotropic glutamate receptor (mGluR) activation. Recent work shows tha... hiện toàn bộ
Handling and environmental enrichment do not rescue learning and memory impairments in αCamKIIT286A mutant mice
Genes, Brain and Behavior - Tập 2 Số 3 - Trang 132-139 - 2003
Anna C. Need, Karl-Peter Giese
Environmental enrichment and postnatal handling have been shown to improve learning and memory in the Morris water maze, and to rescue impairments caused by genetic modification, age or genetic background. Mice with a targeted point mutation that prevents autophosphorylation at threonine‐286 of the α‐isoform of the Ca2+/calmodulin‐dependent kinase II have impaired hippocampus‐dependent and ‐indepe... hiện toàn bộ
Home‐cage activity in heterogeneous stock (HS) mice as a model of baseline activity
Genes, Brain and Behavior - Tập 1 Số 3 - Trang 166-173 - 2002
Jonathan Mill, Michael J. Galsworthy, José L. Payá-Cano, Frans Sluyter, Leonard C. Schalkwyk, Robert Plomin, Philip Asherson
Behavioral genetic work in humans indicates that clinical hyperactivity is best viewed as the extreme end of activity levels in the population. However, current animal models of hyperactivity are not studied as quantitative traits as they are either knockout models or inbred strains. Furthermore, these animal models generally demonstrate elevated locomotion in novel environments, but not in their ... hiện toàn bộ
Standards for the publication of mouse mutant studies
Genes, Brain and Behavior - Tập 8 Số 1 - Trang 1-4 - 2009
Wim E. Crusio, Dan Goldowitz, Andrew Holmes, David P Wolfer
Model of autism: increased ratio of excitation/inhibition in key neural systems
Genes, Brain and Behavior - Tập 2 Số 5 - Trang 255-267 - 2003
John L. R. Rubenstein, Michael M. Merzenich
Autism is a severe neurobehavioral syndrome, arising largely as an inherited disorder, which can arise from several diseases. Despite recent advances in identifying some genes that can cause autism, its underlying neurological mechanisms are uncertain. Autism is best conceptualized by considering the neural systems that may be defective in autistic individuals. Recent advances in understanding neu... hiện toàn bộ
SIRT1 gene, schizophrenia and bipolar disorder in the Japanese population: an association study
Genes, Brain and Behavior - Tập 10 Số 3 - Trang 257-263 - 2011
Taro Kishi, Yasuhisa Fukuo, Tsuyoshi Kitajima, Tomo Okochi, Yoshio Yamanouchi, Yoko Kinoshita, Koichiro Kawashima, Toshiya Inada, Hiroshi Kunugi, Tadafumi Kato, Takeo Yoshikawa, Hiroshi Ujike, Norio Ozaki, Nakao Iwata
Tổng số: 44   
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