Genes, Brain and Behavior
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Phenotyping mouse chromosome substitution strains reveal multiple QTLs for febrile seizure susceptibility Febrile seizures (FS) are the most common seizure type in children and recurrent FS are a risk factor for developing temporal lobe epilepsy. Although the mechanisms underlying FS are largely unknown, recent family, twin and animal studies indicate that genetics are important in FS susceptibility. Here, a forward genetic strategy was used employing mouse chromosome substitution ... ... hiện toàn bộ
Genes, Brain and Behavior - Tập 8 Số 2 - Trang 248-255 - 2009
A phenotypic and molecular characterization of the fmr1‐tm1Cgr Fragile X mouse Fragile X Syndrome is the most common form of inherited mental retardation. It is also known for having a substantial behavioral morbidity, including autistic features. In humans, Fragile X Syndrome is almost always caused by inactivation of the X‐linked FMR1 gene. A single knockout mouse model, fmr1‐tm1Cgr , exists. In this ... ... hiện toàn bộ
Genes, Brain and Behavior - Tập 3 Số 6 - Trang 337-359 - 2004
Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse modelFragile X syndrome (FXS), the most common inherited form of intellectual disability and prevailing known genetic basis of autism, is caused by an expansion in the Fmr1 gene that prevents transcription and translation of fragile X mental retardation protein (FMRP). FMRP binds to and controls translation of mRNAs downstream of metabotropic glutamate rece...
Genes, Brain and Behavior - Tập 11 Số 5 - Trang 586-600 - 2012
The type 1 equilibrative nucleoside transporter regulates anxiety‐like behavior in mice Activation of adenosine receptors in the brain reduces anxiety‐like behavior in animals and humans. Because nucleoside transporters regulate adenosine levels, we used mice lacking the type 1 equilibrative nucleoside transporter (ENT1) to investigate whether ENT1 contributes to anxiety‐like behavior. The ENT1 null mice spent more time in the center of an open field compared with... ... hiện toàn bộ
Genes, Brain and Behavior - Tập 6 Số 8 - Trang 776-783 - 2007
Mitogen‐activated protein kinase/extracellular regulated kinase signalling and memory stabilization: a reviewThe function of mitogen‐activated protein kinase (MAPK) in neurons has been the subject of considerable scrunity of late, and recent studies have given new insights into how this signalling cascade can regulate gene expression following cell‐surface receptor activation. At the same time, a wealth of experimental data has demonstrated that the MAPK cascade is critically involved ...
Genes, Brain and Behavior - Tập 5 Số s2 - Trang 61-72 - 2006
Pleiotropic effects of the 11p13 locus on developmental verbal dyspraxia and EEG centrotemporal sharp waves We recently showed genomewide linkage of centrotemporal sharp waves (CTS) in classic Rolandic epilepsy (RE) families to chromosome 11p13, and fine‐mapped this locus to variants in the ELP4 gene. Speech sound disorder (SSD) is a common comorbidity in RE subjects, of unknown etiology, which co‐aggregates in family members in a manner that could hypothet... ... hiện toàn bộ
Genes, Brain and Behavior - Tập 9 Số 8 - Trang 1004-1012 - 2010
Induction of immediate early genes in the mouse auditory cortex after auditory cued fear conditioning to complex soundsImmediate early genes (IEGs) are widely used as markers to delineate neuronal circuits because they show fast and transient expression induced by various behavioral paradigms. In this study, we investigated the expression of the IEGs c‐fos and Arc in the auditory cortex of the mouse after auditory cued fear conditioning using...
Genes, Brain and Behavior - Tập 11 Số 3 - Trang 314-324 - 2012
A role for activity‐dependent epigenetics in the development and treatment of major depressive disorderChronic stressors, during developmental sensitive periods and beyond, contribute to the risk of developing psychiatric conditions, including major depressive disorder (MDD). Epigenetic mechanisms including DNA methylation and histone modifications, at key stress response and neurotrophin genes, are increasingly implicated in mediating this risk. Although the exact mechanisms through which ... ... hiện toàn bộ
Genes, Brain and Behavior - Tập 17 Số 3 - 2018
Corticotropin‐releasing factor receptor type 2‐deficient mice display impaired coping behaviors during stress Two cognate receptors (CRF1 and CRF2 ) mediate the actions of the stress‐regulatory corticotropin‐releasing factor (CRF) family of peptides. Defining the respective roles of these receptors in the central nervous system is critical in understanding stress neural circuitry and the development of psychiatric disorders. Here, we examined th... ... hiện toàn bộ
Genes, Brain and Behavior - Tập 5 Số 2 - Trang 131-138 - 2006
Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression Unipolar major depressive disorder (MDD) is a prevalent, disabling condition with multiple genetic and environmental factors impacting disease risk. The diagnosis of MDD relies on a cumulative measure derived from multiple trait dimensions and alone is limited in elucidating MDD genetic determinants. We and others have proposed that MDD may be better dissected using paradigms t... ... hiện toàn bộ
Genes, Brain and Behavior - Tập 7 Số 4 - Trang 487-495 - 2008
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