Handling and environmental enrichment do not rescue learning and memory impairments in αCamKIIT286A mutant mice

Genes, Brain and Behavior - Tập 2 Số 3 - Trang 132-139 - 2003
Anna C. Need1, Karl-Peter Giese1
1Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK

Tóm tắt

Environmental enrichment and postnatal handling have been shown to improve learning and memory in the Morris water maze, and to rescue impairments caused by genetic modification, age or genetic background. Mice with a targeted point mutation that prevents autophosphorylation at threonine‐286 of the α‐isoform of the Ca2+/calmodulin‐dependent kinase II have impaired hippocampus‐dependent and ‐independent strategy learning and memory in the water maze. We have investigated whether these impairments can be rescued with a combination of postnatal handling and environmental enrichment in a hybrid genetic background. Severe impairments were seen in acquisition and probe trials in both enriched and nonenriched mutants, indicating that enrichment did not rescue the learning and memory impairments. However, enrichment did rescue a specific performance deficit; enhanced floating behaviour, in the mutants. In summary, we have shown the lack of autophosphorylation of the α‐isoform of the Ca2+/calmodulin‐dependent kinase II prevents enrichment‐induced rescues of strategy learning and memory impairments. Furthermore, we have established that there are enrichment mechanisms that are independent of this autophosphorylation.

Từ khóa


Tài liệu tham khảo

Angelo M., Improved reversal learning and altered fear conditioning in transgenic mice with regionally restriced p25 expression, Eur J Neurosci

10.1037/0735-7044.116.4.600

10.1101/lm.36301

10.1212/01.WNL.0000033588.59005.55

10.1016/S0091-3057(02)00787-6

Fong Y.L., 1989, Studies of the regulatory mechanism of Ca2+/calmodulin‐dependent protein kinase II. Mutation of threonine 286 to alanine and aspartate, J Biol Chem, 264, 16 759, 10.1016/S0021-9258(19)84770-1

10.1037/0735-7044.107.4.618

10.1016/S0361-9230(01)00630-X

10.1126/science.279.5352.870

10.1016/0896-6273(89)90115-3

10.1038/nrn753

10.1016/S0166-4328(02)00026-8

10.1126/science.3340858

10.1016/0092-8674(86)90008-5

10.1016/0896-6273(88)90109-2

10.1046/j.1460-9568.2002.02100.x

10.1093/oxfordjournals.jbchem.a123334

10.1016/S0306-4522(97)00165-6

10.1016/S0166-4328(99)00019-4

10.1038/35044558

10.1016/S0166-4328(00)00186-8

10.1038/72945

10.1016/S0031-9384(02)00856-9

10.1016/S0091-3057(02)00790-6

10.1016/0165-3806(92)90028-U

10.1038/ng0597-19

10.1016/0006-8993(95)01411-X

10.1101/lm.43101

10.1016/S0028-3908(01)00122-8

10.1016/S0166-4328(99)00074-1

10.1007/s003359900453

10.1034/j.1601-183X.2002.10405.x

10.1073/pnas.87.4.1273

10.1016/S0031-9384(01)00543-1

10.1016/S0031-9384(01)00531-5

Zaharia M.D., 1996, The effects of early postnatal stimulation on Morris water‐maze acquisition in adult mice: genetic and maternal factors, Psychopharmacology (Berl, 128, 227, 10.1007/s002130050130

Thông tin
Thông tin xuất bản

Genes, Brain and Behavior

Tập 2 Số 3

132-139

Thông tin tác giả