Genes, Brain and Behavior
SCIE-ISI SCOPUS (2002-2023)
1601-183X
1601-1848
Anh Quốc
Cơ quản chủ quản: WILEY , Wiley-Blackwell Publishing Ltd
Lĩnh vực:
Behavioral NeuroscienceGeneticsNeurology
Các bài báo tiêu biểu
Model of autism: increased ratio of excitation/inhibition in key neural systems Autism is a severe neurobehavioral syndrome, arising largely as an inherited disorder, which can arise from several diseases. Despite recent advances in identifying some genes that can cause autism, its underlying neurological mechanisms are uncertain. Autism is best conceptualized by considering the neural systems that may be defective in autistic individuals. Recent advances ... ... hiện toàn bộ
Tập 2 Số 5 - Trang 255-267 - 2003
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice Deficits in social interaction are important early markers for autism and related neurodevelopmental disorders with strong genetic components. Standardized behavioral assays that measure the preference of mice for initiating social interactions with novel conspecifics would be of great value for mutant mouse models of autism. We developed a new procedure to assess sociability a... ... hiện toàn bộ
Tập 3 Số 5 - Trang 287-302 - 2004
Autism‐like behavioral phenotypes in BTBR T+tf/J mice Autism is a behaviorally defined neurodevelopmental disorder of unknown etiology. Mouse models with face validity to the core symptoms offer an experimental approach to test hypotheses about the causes of autism and translational tools to evaluate potential treatments. We discovered that the inbred mouse strain BTBR T+tf/J (BTBR) incorporates multiple behavioral phenotypes rele... ... hiện toàn bộ
Tập 7 Số 2 - Trang 152-163 - 2008
Automated apparatus for quantitation of social approach behaviors in mice Mouse models of social dysfunction, designed to investigate the complex genetics of social behaviors, require an objective methodology for scoring social interactions relevant to human disease symptoms. Here we describe an automated, three chambered apparatus designed to monitor social interaction in the mouse. Time spent in each chamber and the number of entries are scored aut... ... hiện toàn bộ
Tập 3 Số 5 - Trang 303-314 - 2004
Neuroligin‐3‐deficient mice: model of a monogenic heritable form of autism with an olfactory deficit Autism spectrum disorder (ASD) is a frequent neurodevelopmental disorder characterized by variable clinical severity. Core symptoms are qualitatively impaired communication and social behavior, highly restricted interests and repetitive behaviors. Although recent work on genetic mutations in ASD has shed light on the pathophysiology of the disease, classifying it essentially as... ... hiện toàn bộ
Tập 8 Số 4 - Trang 416-425 - 2009
Down's syndrome: a genetic disorder in biobehavioral perspective Down's syndrome is a genetic disorder that can lead to mental retardation of varying degrees. How this chromosomal abnormality causes mental retardation remains an open question. This paper reviews what is currently known about the neural and cognitive features of Down's syndrome, noting the growing evidence of disproportionate impairment of specific systems such as the hippoca... ... hiện toàn bộ
Tập 2 Số 3 - Trang 156-166 - 2003
A phenotypic and molecular characterization of the fmr1‐tm1Cgr Fragile X mouse Fragile X Syndrome is the most common form of inherited mental retardation. It is also known for having a substantial behavioral morbidity, including autistic features. In humans, Fragile X Syndrome is almost always caused by inactivation of the X‐linked FMR1 gene. A single knockout mouse model, fmr1‐tm1Cgr , exists. In this ... ... hiện toàn bộ
Tập 3 Số 6 - Trang 337-359 - 2004
Dendritic pathology in mental retardation: from molecular genetics to neurobiology Mental retardation (MR) is a developmental brain disorder characterized by impaired cognitive performance and adaptive skills that affects 1–2% of the population. During the last decade, a large number of genes have been cloned that cause MR upon mutation in humans. The causal role of these genes provides an excellent starting point to investigate the cellular, neurobiological ... ... hiện toàn bộ
Tập 5 Số s2 - Trang 48-60 - 2006
Visual detection, pattern discrimination and visual acuity in 14 strains of mice Based on the procedure of Prusky et al . (2000, Vision Research , 40, 2201–2209), we used a computer‐based, two‐alternative swim task to evaluate visual detection, pattern discrimination and visual acuity in 14 strains of mice from priority groups A and B of the JAX phenome project (129S1/SvImJ, A/J, AKR/J, BALB/cByJ, BALB/cJ,... ... hiện toàn bộ
Tập 5 Số 5 - Trang 389-403 - 2006
CNTNAP2variants affect early language development in the general population
Tập 10 Số 4 - Trang 451-456 - 2011