Genes, Brain and Behavior
SCIE-ISI SCOPUS (2002-2025)
1601-183X
1601-1848
Anh Quốc
Cơ quản chủ quản: WILEY , Wiley-Blackwell Publishing Ltd
Lĩnh vực:
Behavioral NeuroscienceGeneticsNeurology
Các bài báo tiêu biểu
Model of autism: increased ratio of excitation/inhibition in key neural systems
Tập 2 Số 5 - Trang 255-267 - 2003
Autism is a severe neurobehavioral syndrome, arising largely as an inherited
disorder, which can arise from several diseases. Despite recent advances in
identifying some genes that can cause autism, its underlying neurological
mechanisms are uncertain. Autism is best conceptualized by considering the
neural systems that may be defective in autistic individuals. Recent advances in
understanding neu...
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice
Tập 3 Số 5 - Trang 287-302 - 2004
Deficits in social interaction are important early markers for autism and
related neurodevelopmental disorders with strong genetic components.
Standardized behavioral assays that measure the preference of mice for
initiating social interactions with novel conspecifics would be of great value
for mutant mouse models of autism. We developed a new procedure to assess
sociability and the preference fo...
Autism‐like behavioral phenotypes in BTBR T+tf/J mice
Tập 7 Số 2 - Trang 152-163 - 2008
Autism is a behaviorally defined neurodevelopmental disorder of unknown
etiology. Mouse models with face validity to the core symptoms offer an
experimental approach to test hypotheses about the causes of autism and
translational tools to evaluate potential treatments. We discovered that the
inbred mouse strain BTBR T+tf/J (BTBR) incorporates multiple behavioral
phenotypes relevant to all three di...
Automated apparatus for quantitation of social approach behaviors in mice
Tập 3 Số 5 - Trang 303-314 - 2004
Mouse models of social dysfunction, designed to investigate the complex genetics
of social behaviors, require an objective methodology for scoring social
interactions relevant to human disease symptoms. Here we describe an automated,
three chambered apparatus designed to monitor social interaction in the mouse.
Time spent in each chamber and the number of entries are scored automatically by
a syst...
Neuroligin‐3‐deficient mice: model of a monogenic heritable form of autism with an olfactory deficit
Tập 8 Số 4 - Trang 416-425 - 2009
Autism spectrum disorder (ASD) is a frequent neurodevelopmental disorder
characterized by variable clinical severity. Core symptoms are qualitatively
impaired communication and social behavior, highly restricted interests and
repetitive behaviors. Although recent work on genetic mutations in ASD has shed
light on the pathophysiology of the disease, classifying it essentially as a
synaptopathy, no ...
Down's syndrome: a genetic disorder in biobehavioral perspective
Tập 2 Số 3 - Trang 156-166 - 2003
Down's syndrome is a genetic disorder that can lead to mental retardation of
varying degrees. How this chromosomal abnormality causes mental retardation
remains an open question. This paper reviews what is currently known about the
neural and cognitive features of Down's syndrome, noting the growing evidence of
disproportionate impairment of specific systems such as the hippocampal
formation, the ...
A phenotypic and molecular characterization of the fmr1‐tm1Cgr Fragile X mouse
Tập 3 Số 6 - Trang 337-359 - 2004
Fragile X Syndrome is the most common form of inherited mental retardation. It
is also known for having a substantial behavioral morbidity, including autistic
features. In humans, Fragile X Syndrome is almost always caused by inactivation
of the X‐linked FMR1 gene. A single knockout mouse model, fmr1‐tm1Cgr, exists.
In this report we further characterize the cognitive and behavioral phenotype of
t...
Dendritic pathology in mental retardation: from molecular genetics to neurobiology
Tập 5 Số s2 - Trang 48-60 - 2006
Mental retardation (MR) is a developmental brain disorder characterized by
impaired cognitive performance and adaptive skills that affects 1–2% of the
population. During the last decade, a large number of genes have been cloned
that cause MR upon mutation in humans. The causal role of these genes provides
an excellent starting point to investigate the cellular, neurobiological and
behavioral alter...
Visual detection, pattern discrimination and visual acuity in 14 strains of mice
Tập 5 Số 5 - Trang 389-403 - 2006
Based on the procedure of Prusky et al. (2000, Vision Research, 40, 2201–2209),
we used a computer‐based, two‐alternative swim task to evaluate visual
detection, pattern discrimination and visual acuity in 14 strains of mice from
priority groups A and B of the JAX phenome project (129S1/SvImJ, A/J, AKR/J,
BALB/cByJ, BALB/cJ, C3H/HeJ, C57BL/6J, CAST/Ei, DBA/2J, FVB/NJ, MOLF/Ei, SJL/J,
SM/J and SPRE...
CNTNAP2variants affect early language development in the general population
Tập 10 Số 4 - Trang 451-456 - 2011