Nicotinic acetylcholine receptors: upregulation, age‐related effects and associations with drug use

Genes, Brain and Behavior - Tập 15 Số 1 - Trang 89-107 - 2016
Whitney E. Melroy-Greif1, Jerry A. Stitzel2,3, Marissa A. Ehringer2,3
1Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA, USA
2Department of Integrative Physiology, University of Colorado Boulder, CO, USA
3Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA

Tóm tắt

Nicotinic acetylcholine receptors are ligand‐gated ion channels that exogenously bind nicotine. Nicotine produces rewarding effects by interacting with these receptors in the brain's reward system. Unlike other receptors, chronic stimulation by an agonist induces an upregulation of receptor number that is not due to increased gene expression in adults; while upregulation also occurs during development and adolescence there have been some opposing findings regarding a change in corresponding gene expression. These receptors have also been well studied with regard to human genetic associations and, based on evidence suggesting shared genetic liabilities between substance use disorders, numerous studies have pointed to a role for this system in comorbid drug use. This review will focus on upregulation of these receptors in adulthood, adolescence and development, as well as the findings from human genetic association studies which point to different roles for these receptors in risk for initiation and continuation of drug use.

Từ khóa


Tài liệu tham khảo

10.3109/10408444.2012.658506

10.1038/sj.npp.1300221

10.1038/sj.npp.1300401

10.1523/JNEUROSCI.23-11-04712.2003

10.1111/j.1360-0443.2008.02213.x

10.1023/B:BEGE.0000017868.07829.45

Anand R., 1991, Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure, J Biol Chem, 266, 11192, 10.1016/S0021-9258(18)99147-7

10.1371/journal.pone.0088240

10.1111/j.1749-6632.1981.tb33732.x

10.1093/ntr/ntp064

Bencherif M., 1995, Mechanisms of up‐regulation of neuronal nicotinic acetylcholine receptors in clonal cell lines and primary cultures of fetal rat brain, J Pharmacol Exp Ther, 275, 987

10.1146/annurev.pa.36.040196.003121

10.1111/j.1471-4159.1988.tb10600.x

10.1097/FPC.0b013e32835cdabd

10.1038/mp.2011.122

10.1038/sj.mp.4002154

10.1001/archpsyc.55.11.982

10.1093/hmg/ddl441

10.1176/appi.ajp.2008.07111711

10.1073/pnas.84.21.7763

Breese C.R., 1997, Effect of smoking history on [3H]nicotine binding in human postmortem brain, J Pharmacol Exp Ther, 282, 7

10.1002/cne.903170402

10.1375/twin.9.1.64

10.1093/ntr/ntr283

10.1093/ntr/ntt125

10.1371/journal.pone.0004653

CDC Centers for Disease Control and Prevention. (2008) National Center for Chronic Disease Prevention and Health Promotion Office on Smoking and Health Department of Health and Human Services. Smoking and Tobacco Use—Fact Sheet: Health Effects of Cigarette Smoking. Updated January 2008. URLhttp://www.cdc.gov/tobacco/data_statistics/fact_sheets/health_effects/effects_cig_smoking/index.htm

CDC Centers for Disease Control and Prevention. National Center for Chronic Disease Prevention and Health Promotion Office on Smoking and Health Department of Health and Human Services. Tobacco Use: Targeting the Nation's Leading Killer—At a Glance2009. URLhttp://www.cdc.gov/chronicdisease/resources/publications/aag/pdf/tobacco.pdf

10.1038/nrn2849

10.1016/j.jfda.2013.09.041

10.1111/j.1460-9568.2005.04229.x

10.1002/ajmg.b.30919

10.1093/ntr/ntr231

10.1176/appi.ajp.2012.11101545

Chen H.I., 2013, Possible association of nicotinic acetylcholine receptor gene (CHRNA4 and CHRNB2) polymorphisms with nicotine dependence in Japanese males: an exploratory study, Pharmacopsychiatry, 46, 77

10.1038/sj.emboj.7600436

10.1093/ntr/ntv166

10.1007/BF00177905

10.1016/0361-9230(90)90222-L

10.1093/hmg/ddn181

10.1111/acer.12319

10.1097/00002093-199501002-00003

10.1016/0896-6273(90)90344-F

10.1146/annurev.pa.21.040181.002041

10.1038/mp.2012.190

10.1111/add.12478

10.1074/jbc.M501157200

10.1038/tp.2012.41

10.1016/0896-6273(88)90208-5

10.1016/j.brainres.2008.03.056

10.1016/0896-6273(89)90207-9

10.1016/j.pharmthera.2009.02.003

10.1002/ajmg.b.30464

10.1002/ajmg.b.31027

10.1016/0092-8674(94)90555-X

10.1073/pnas.051622798

10.1016/S0006-8993(99)02231-3

10.1007/s00439-010-0876-6

10.1086/422194

10.1074/jbc.M506781200

Flores C.M., 1992, A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up‐regulated by chronic nicotine treatment, Mol Pharmacol, 41, 31

10.1152/ajpregu.2001.280.4.R1134

10.1093/hmg/ddp216

10.1097/00001756-199707280-00005

10.1046/j.1460-9568.1998.00001.x

10.1038/ng.571

10.1038/ejhg.2013.26

10.1016/0092-8674(79)90039-4

Gerzanich V., 1998, alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors, J Pharmacol Exp Ther, 286, 311

10.1016/j.brainresbull.2009.12.006

10.1016/j.brainres.2008.10.076

10.1124/mol.52.3.524

10.1016/j.bcp.2009.05.024

10.1523/JNEUROSCI.5438-11.2012

10.1074/jbc.273.25.15317

10.1016/j.biopsych.2008.04.018

10.1001/jama.1988.03720190003002

10.1016/0736-5748(85)90046-2

10.1093/hmg/ddr498

10.1093/hmg/ddt463

10.1371/journal.pone.0096753

Hallfors J., 2013, Scrutiny of the CHRNA5‐CHRNA3‐CHRNB4 smoking behavior locus reveals a novel association with alcohol use in a Finnish population based study, Int J Mol Epidemiol Genet, 4, 109

10.1002/ajmg.b.31177

10.1523/JNEUROSCI.22-23-10172.2002

10.1001/archgenpsychiatry.2012.124

10.1016/j.physbeh.2010.08.021

10.1038/npp.2010.130

10.1002/ajmg.b.30669

10.1016/S0306-4522(01)00209-3

10.1016/j.neuropharm.2015.01.022

10.1016/0376-8716(93)90030-T

10.1111/j.1601-183X.2009.00495.x

10.1038/npp.2008.122

10.1111/j.1601-183X.2010.00650.x

10.1097/01.CHI.0000046848.56865.54

10.1016/j.brainres.2006.06.084

10.1146/annurev.clinpsy.4.022007.141157

10.1073/pnas.0810970105

10.1111/gbb.12021

10.1016/0091-3057(94)90293-3

10.1371/journal.pone.0033513

10.1016/j.pbb.2006.10.007

Ke L., 1998, Effects of chronic nicotine treatment on expression of diverse nicotinic acetylcholine receptor subtypes. I. Dose‐ and time‐dependent effects of nicotine treatment, J Pharmacol Exp Ther, 286, 825

10.1016/S0079-6123(08)62480-2

10.1192/bjp.170.6.541

10.1017/S0033291798008022

10.1176/appi.ajp.160.4.687

10.1001/archpsyc.64.11.1313

10.1001/archpsyc.1997.01830160031005

10.1016/j.alcohol.2004.06.004

10.1016/S0028-3908(00)00144-1

10.1124/mol.105.012419

10.1124/mol.104.006429

10.1016/j.brainres.2009.08.026

10.1371/journal.pone.0087141

10.1002/neu.10153

10.1017/S0033291703001582

10.1016/j.ntt.2007.02.002

10.1093/hmg/ddi132

10.1371/journal.pone.0012183

10.1007/978-1-4899-1775-1_10

10.1038/ng.572

10.1038/npp.2011.25

10.1007/s10519-012-9529-y

10.1523/JNEUROSCI.11-03-00837.1991

10.1002/(SICI)1096-9861(19980413)393:3<320::AID-CNE5>3.0.CO;2-3

Lustig L.R., 1999, Vestibular hair cells of the chick express the nicotinic acetylcholine receptor subunit alpha 9, J Vestib Res, 9, 359, 10.3233/VES-1999-9505

10.1006/geno.2000.6503

10.1523/JNEUROSCI.09-03-01082.1989

10.1016/j.neuro.2008.04.015

10.1007/s10519-011-9476-z

10.2967/jnumed.107.043471

10.1111/j.1471-4159.2007.05011.x

Marks M.J., 1983, Effects of chronic nicotine infusion on tolerance development and nicotinic receptors, J Pharmacol Exp Ther, 226, 817

Marks M.J., 1985, Time course study of the effects of chronic nicotine infusion on drug response and brain receptors, J Pharmacol Exp Ther, 235, 619

10.1523/JNEUROSCI.12-07-02765.1992

10.1124/jpet.110.178236

10.1111/jnc.12721

Mathews T.J., 2001, Smoking during pregnancy in the 1990s, Natl Vital Stat Rep, 49, 1

10.1007/s00213-006-0441-0

10.1124/jpet.113.209767

10.1001/archpsyc.55.11.973

10.1046/j.1471-4159.1998.70020752.x

10.1016/j.neuropharm.2008.07.041

10.1016/S0306-4522(03)00460-3

10.1016/j.neuroscience.2005.09.008

10.1111/bph.12741

10.1093/jnci/djs191

10.1097/00001756-200205240-00012

10.1523/JNEUROSCI.23-37-11554.2003

Navarro H.A., 1989, Effects of prenatal nicotine exposure on development of central and peripheral cholinergic neurotransmitter systems. Evidence for cholinergic trophic influences in developing brain, J Pharmacol Exp Ther, 251, 894

NIDA National Institute on Drug Abuse. (2015) Nationwide Trends. URLhttp://www.drugabuse.gov/publications/drugfacts/nationwide‐trends(Date of last access April 9 2015)

10.1073/pnas.75.7.3488

10.1093/toxsci/kfr147

Olale F., 1997, Chronic nicotine exposure differentially affects the function of human alpha3, alpha4, and alpha7 neuronal nicotinic receptor subtypes, J Pharmacol Exp Ther, 283, 675

10.1038/mp.2015.105

10.1016/j.drugalcdep.2009.01.012

10.1016/j.drugalcdep.2011.12.015

10.1111/add.12815

10.1016/0896-6273(89)90269-9

10.1111/j.1651-2227.2008.00852.x

Pauly J.R., 1991, An autoradiographic analysis of cholinergic receptors in mouse brain after chronic nicotine treatment, J Pharmacol Exp Ther, 258, 1127

10.1016/j.addbeh.2013.08.033

Peng X., 1994, Nicotine‐induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover, Mol Pharmacol, 46, 523

10.1124/mol.51.5.776

Perry D.C., 1999, Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies, J Pharmacol Exp Ther, 289, 1545

10.1124/jpet.107.121228

10.1016/0376-8716(95)01151-N

10.1016/S0091-3057(97)98985-1

Pugh P.C., 1995, Novel subpopulation of neuronal acetylcholine receptors among those binding alpha‐bungarotoxin, Mol Pharmacol, 47, 717

Putney J.W., 1971, On the mechanisms of 14C‐nicotine distribution in rat submaxillary gland in vitro, J Pharmacol Exp Ther, 178, 180

10.1038/380347a0

10.1016/j.neulet.2006.05.010

10.1523/JNEUROSCI.3353-07.2007

10.1523/JNEUROSCI.4723-08.2009

10.1001/archpsyc.60.12.1256

10.1016/j.drugalcdep.2005.12.003

10.1111/j.1360-0443.2012.03922.x

10.1007/s00213-005-0250-x

10.1093/hmg/ddl438

10.1002/ajmg.b.30828

10.1158/0008-5472.CAN-09-0786

10.1371/journal.pgen.1001053

10.1111/j.1601-183X.2010.00608.x

10.1038/srep04497

10.1016/j.neuron.2005.03.029

10.1124/mol.65.6.1526

10.1002/ajmg.b.31155

10.1111/j.1471-4159.2007.04980.x

10.1016/j.biopsych.2007.10.024

10.1016/0896-6273(90)90031-A

10.1126/science.6828889

10.1124/mol.61.1.150

10.1016/S0306-4522(97)00564-2

10.1111/j.1360-0443.2008.02279.x

10.1038/npp.2010.64

10.1111/j.1471-4159.1988.tb10604.x

Slotkin T.A., 1987, Development of [3H]nicotine binding sites in brain regions of rats exposed to nicotine prenatally via maternal injections or infusions, J Pharmacol Exp Ther, 242, 232

10.1016/S0165-3806(02)00281-X

10.1016/j.brainres.2004.10.009

10.1016/j.brainresbull.2007.05.007

10.1016/j.brainresbull.2007.12.009

10.1038/ejhg.2010.240

10.1093/jnci/djn363

10.1002/gepi.21760

10.1158/1055-9965.EPI-08-0585

10.1007/BF02245088

10.1016/S0169-328X(99)00302-2

10.1093/nar/21.2.233

10.1038/nature06846

10.1038/ng.573

10.1016/S0091-3057(00)00379-8

10.1016/S0091-3057(96)00461-3

10.1016/S0091-3057(00)00171-4

10.1016/S0006-8993(99)01994-0

10.1002/(SICI)1096-8628(19990820)88:4<391::AID-AJMG17>3.0.CO;2-L

10.1001/archpsyc.56.7.655

10.1080/10673220127912

10.1124/mol.106.027326

UNODC United Nations Office on Drugs and Crime. (2012) World Drug Report 2012 (United Nations publication Sales No. E.12.XI.1).

10.1523/JNEUROSCI.5240-04.2005

10.1016/j.neubiorev.2003.08.002

10.1016/S0896-6273(00)80756-4

10.1038/sj.tpj.6500255

10.1002/cne.902840212

10.1074/jbc.271.30.17656

10.1074/jbc.273.44.28721

10.1038/mp.2008.42

10.1007/s00439-013-1398-9

10.1371/journal.pgen.1000125

10.1038/npp.2010.120

WHO World Health Organization. (2014) Alcohol: fact sheet. Updated May 2014. URLhttp://www.who.int/mediacentre/factsheets/fs349/en/

WHO World Health Organization. (2015) Tobacco: Fact sheet N°339. Updated July2015. Available at:http://www.who.int/mediacentre/factsheets/fs339/en/

10.1002/ajmg.b.31126

10.2741/2708

10.1016/0165-6147(90)90242-Z

10.1111/j.1360-0443.2008.02243.x

10.1016/j.biopsych.2011.04.017

10.1038/ejhg.2014.229

10.1016/S0376-8716(02)00225-9

10.1007/s10519-006-9066-7

10.1093/hmg/ddm344

10.1097/00001756-199501000-00022

10.1038/jhg.2012.104

10.1111/add.12250

10.1038/clpt.2014.88