A discrete amino terminal domain of Kv1.5 and Kv1.4 potassium channels interacts with the spectrin repeats of α‐actinin‐2FEBS Letters - Tập 498 - Trang 87-92 - 2001
D. Cukovic, G.W-K. Lu, B. Wible, D.F. Steele, D. Fedida
The interaction between the amino terminus of Kv1‐type potassium channels and α‐actinin‐2 has been investigated. Using a combination of yeast two‐hybrid analysis and in vitro binding assays, α‐actinin‐2 was found to bind to the N‐termini of both Kv1.4 and Kv1.5 but not to the equivalent segments of Kv1.1, Kv1.2 or Kv1.3. Deletion analysis in the in vitro binding assays delineated the actin...... hiện toàn bộ
p15INK4b in HDAC inhibitor‐induced growth arrestFEBS Letters - Tập 554 - Trang 347-350 - 2003
Toshiaki Hitomi, Youichirou Matsuzaki, Tomoya Yokota, Yuuki Takaoka, Toshiyuki Sakai
Histone deacetylase (HDAC) inhibitors arrest human tumor cells at the G1 phase of the cell cycle and activate the cyclin‐dependent kinase inhibitor, p21WAF1/Cip1. However, several studies have suggested the existence of a p21WAF1/Cip1‐independent molecular pathway. We report here that HDAC inhibitors, trichostatin A (TSA) and sodium butyrate, activ...... hiện toàn bộ
Oxidative stress, aging and longevity in Drosophila melanogasterFEBS Letters - Tập 498 Số 2-3 - Trang 183-186 - 2001
Éric Le Bourg
Free radicals produced during normal metabolism cause damage to macromolecules. The free radical theory of aging proposes that the organism is unable to repair all of them and that, with time, unrepaired damages accumulate and put the organism at risk: in other words, free radicals provoke aging and death. This article reviews both the results of adding antioxidants to food on longevity in...... hiện toàn bộ
Effect of glucocorticoids on the synthesis of antimicrobial peptides in amphibian skinFEBS Letters - Tập 416 - Trang 273-275 - 1997
Maurizio Simmaco, Anita Boman, Maria Luisa Mangoni, Giuseppina Mignogna, Rossella Miele, Donatella Barra, Hans G Boman
Gene‐encoded peptide antibiotics are widespread in insects, plants and vertebrates and confer protection against bacterial and fungal infections. NF‐κB is an important transcription factor for many immunity‐related mammalian proteins and also for insect immune genes. The activity of NF‐κB is regulated by the interaction with an inhibitor, IκB. It was recently demonstrated that glucocortico...... hiện toàn bộ
Oxidized glutathione stimulated the amyloid formation of α‐synucleinFEBS Letters - Tập 537 - Trang 63-67 - 2003
Seung R. Paik, Daekyun Lee, Hyun-Ju Cho, Eui-Nam Lee, Chung-Soon Chang
α‐Synuclein is the major filamentous constituent of Lewy bodies found in Parkinson's disease (PD). The amyloid formation of α‐synuclein was significantly facilitated by oxidized glutathione (GSSG) as the lag period of the aggregation kinetics was shortened by 2.5‐fold from its absence. Reduced glutathione (GSH), on the other hand, did not influence the lag phase although it increased the f...... hiện toàn bộ