Ceruloplasmin and the reactions forming differic transferrinFEBS Letters - Tập 159 - Trang 137-140 - 1983
M.V. Chidambaram, G. Barnes, E. Frieden
The rate of formation of diferric‐transferrin has been studied using various combinations of Fe(II), Tf, Cp and h serum. When the reactants were added in a correct physiological sequence, ceruloplasmin and diluted human serum showed the fastest rate of saturation of transferrin.
Spatial localization of the stimulus‐induced rise in cytosolic Ca2+ in bovine adrenal chromaffin cellsFEBS Letters - Tập 247 - Trang 429-434 - 1989
Timothy R. Cheek, Antony J. O'Sullivan, Roger B. Moreton, Michael J. Berridge, Robert D. Burgoyne
The spatial distribution of the intracellular free Ca2+ (Ca2+
i) rise elicited by different stimuli in bovine adrenal chromaffin cells was examined in single fura‐2‐loaded cells. In response to the potent secretagogues nicotine and high K+, Ca2+
i was initially loca...... hiện toàn bộ
A discrete amino terminal domain of Kv1.5 and Kv1.4 potassium channels interacts with the spectrin repeats of α‐actinin‐2FEBS Letters - Tập 498 - Trang 87-92 - 2001
D. Cukovic, G.W-K. Lu, B. Wible, D.F. Steele, D. Fedida
The interaction between the amino terminus of Kv1‐type potassium channels and α‐actinin‐2 has been investigated. Using a combination of yeast two‐hybrid analysis and in vitro binding assays, α‐actinin‐2 was found to bind to the N‐termini of both Kv1.4 and Kv1.5 but not to the equivalent segments of Kv1.1, Kv1.2 or Kv1.3. Deletion analysis in the in vitro binding assays delineated the actin...... hiện toàn bộ
p15INK4b in HDAC inhibitor‐induced growth arrestFEBS Letters - Tập 554 - Trang 347-350 - 2003
Toshiaki Hitomi, Youichirou Matsuzaki, Tomoya Yokota, Yuuki Takaoka, Toshiyuki Sakai
Histone deacetylase (HDAC) inhibitors arrest human tumor cells at the G1 phase of the cell cycle and activate the cyclin‐dependent kinase inhibitor, p21WAF1/Cip1. However, several studies have suggested the existence of a p21WAF1/Cip1‐independent molecular pathway. We report here that HDAC inhibitors, trichostatin A (TSA) and sodium butyrate, activ...... hiện toàn bộ
Oxidative stress, aging and longevity in Drosophila melanogasterFEBS Letters - Tập 498 Số 2-3 - Trang 183-186 - 2001
Éric Le Bourg
Free radicals produced during normal metabolism cause damage to macromolecules. The free radical theory of aging proposes that the organism is unable to repair all of them and that, with time, unrepaired damages accumulate and put the organism at risk: in other words, free radicals provoke aging and death. This article reviews both the results of adding antioxidants to food on longevity in...... hiện toàn bộ