Effect of glucocorticoids on the synthesis of antimicrobial peptides in amphibian skin

FEBS Letters - Tập 416 - Trang 273-275 - 1997
Maurizio Simmaco1,2, Anita Boman3, Maria Luisa Mangoni1, Giuseppina Mignogna2, Rossella Miele2, Donatella Barra2, Hans G Boman3
1Dipartimento di Scienze Biomediche, Università di Chieti, 66100 Chieti, Italy
2Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche and CNR Centro di Biologia Molecolare, Università `La Sapienza', Piazzale Aldo Moro 5, 00185 Rome, Italy
3Department of Microbiology Stockholm University S-106 91 Stockholm Sweden

Tóm tắt

Gene‐encoded peptide antibiotics are widespread in insects, plants and vertebrates and confer protection against bacterial and fungal infections. NF‐κB is an important transcription factor for many immunity‐related mammalian proteins and also for insect immune genes. The activity of NF‐κB is regulated by the interaction with an inhibitor, IκB. It was recently demonstrated that glucocorticoids induce the synthesis of IκB in human cell lines. So far, all genes for peptide antibiotics have promoter motifs with NF‐κB binding sites, but its actual function in peptide regulation has been studied only in insects. Here we show that glucocorticoid treatment of the frog Rana esculenta inhibits the transcription of all genes encoding antibacterial peptides by inducing the synthesis of IκBα. These results suggest that also in vertebrates peptide‐mediated innate immunity is controlled by NF‐κB‐regulated transcription.

Tài liệu tham khảo

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FEBS Letters

Tập 416

273-275

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