Oxidative stress, aging and longevity in Drosophila melanogaster

FEBS Letters - Tập 498 Số 2-3 - Trang 183-186 - 2001
Éric Le Bourg1
1Laboratoire d’Éthologie et Cognition Animale, E.R.S. C.N.R.S. no 2382, Université Paul-Sabatier, 118 route de Narbonne, F-31062 Toulouse Cedex 4, France

Tóm tắt

Free radicals produced during normal metabolism cause damage to macromolecules. The free radical theory of aging proposes that the organism is unable to repair all of them and that, with time, unrepaired damages accumulate and put the organism at risk: in other words, free radicals provoke aging and death. This article reviews both the results of adding antioxidants to food on longevity in Drosophila melanogaster, as well as the studies on antioxidant enzymes (inactivation in vivo, null mutants, overexpression). It is concluded that antioxidant enzymes are probably poorly connected to the normal aging process, but they allow the organism to cope with stressful conditions.

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Tài liệu tham khảo

Pearl R. (1928) The Rate of Living Knopf London.

10.1093/geronj/11.3.298

10.1038/35041687

10.1016/0531-5565(88)90020-4

10.1159/000212660

10.1016/0531-5565(87)90034-9

Sohal R.S. (1986) in: Insect Aging (Collatz K.-G. and Sohal R.S. Eds.) pp. 23–44 Springer-Verlag Berlin.

10.1002/em.2850180104

10.1016/0531-5565(82)90043-2

Cellucci M.D. Davis F. and Baker III G.T. (1984) in: Altered Endocrine Status During Aging pp. 245–248 Alan R. Liss New York.

10.1007/BF02431773

10.1016/0531-5565(79)90039-1

Massie H.R. (1988) in:Drosophilaas a Model Organism for Ageing Studies (Lints F.A. and Soliman M.H. Eds.) pp. 59–70 Blackie Glasgow.

10.1016/0531-5565(96)00003-4

10.1016/S0047-6374(97)01897-6

10.1016/0047-6374(90)90084-S

10.1016/0047-6374(84)90069-1

10.1016/0531-5565(73)90020-X

10.1073/pnas.86.8.2761

10.1073/pnas.87.11.4270

10.1016/0047-6374(92)90006-Y

10.1093/genetics/134.3.781

10.1093/genetics/122.3.643

10.1016/0003-9861(92)90637-C

10.1128/MCB.19.1.216

10.1139/g90-130

10.1128/MCB.11.2.632

10.3109/10715769209061090

10.1038/534

10.1126/science.8108730

10.1006/abbi.1999.1460

10.1016/S0047-6374(00)00152-4

10.1096/fasebj.13.13.1733

10.1126/science.291.5504.643

10.1016/S0047-6374(99)00024-X

10.1093/gerona/55.7.B329

Minois N. Khazaeli A.A. and Curtsinger J.W. (2001) Exp. Geront. in press.

10.1007/BF03324120

10.1016/0167-4943(82)90016-4

10.1016/0531-5565(91)90078-Z

10.1016/0531-5565(91)90037-M

10.1016/0531-5565(93)90049-J

10.1007/PL00013199

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FEBS Letters

Tập 498 Số 2-3

183-186

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