European Neurology
1421-9913
0014-3022
Thụy Sĩ
Cơ quản chủ quản: KARGER , S. Karger AG
Lĩnh vực:
NeurologyNeurology (clinical)
Phân tích ảnh hưởng
Thông tin về tạp chí
"European Neurology" publishes original papers, reviews and letters to the editor. Papers presented in this journal cover clinical aspects of diseases of the nervous system and muscles, as well as their neuropathological, biochemical, and electrophysiological basis. New diagnostic probes, pharmacological and surgical treatments are evaluated from clinical evidence and basic investigative studies. The journal also features original works and reviews on the history of neurology.
Các bài báo tiêu biểu
Electrophysiological Abnormalities in Cases of Dystrophia Myotonica
Tập 13 Số 4 - Trang 360-376 - 1975
White Matter Changes in Stroke Patients White matter changes (WMC), detected by imaging techniques, are frequent in stroke patients. The aim of the study was to determine how WMC relate to stroke subtypes and to stroke outcome. We made a systematic Medline search for articles appearing with two of the following key words: either ‘WMC or white matter lesions or leukoencephalopathy or leukoaraiosis’ and ‘stroke or cerebral infarct or cerebral hemorrhage or cerebrovascular disease or transient ischemic attack (TIA)’. WMC, as defined radiologically, are present in up to 44% of patients with stroke or TIA and in 50% of patients with vascular dementia. WMC are more frequent in patients with lacunar infarcts, deep intracerebral hemorrhages, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy and cerebral amyloid angiopathy. After an acute ischemic stroke, WMC are associated with a higher risk of death or dependency, recurrent stroke of any type, cerebral bleeding under anticoagulation, myocardial infarction, and poststroke dementia. WMC in stroke patients are often associated with small-vessel disease and lead to a higher risk of death, and poor cardiac and neurological outcome. However, several questions remain open and need further investigations.
Tập 42 Số 2 - Trang 67-75 - 1999
Loss of Dopamine Uptake Sites Labeled with [<sup>3</sup>H]GBR-12935 in Alzheimer’s Disease
Tập 30 Số 4 - Trang 181-185 - 1990
Nonlinear Dynamics Measures for Automated EEG-Based Sleep Stage Detection <b><i>Background:</i></b> The brain's continuous neural activity during sleep can be monitored by electroencephalogram (EEG) signals. The EEG wave pattern and frequency vary during five stages of sleep. These subtle variations in sleep EEG signals cannot be easily detected through visual inspection. <b><i>Summary:</i></b> A range of time, frequency, time-frequency and nonlinear analysis methods can be applied to understand the complex physiological signals and their chaotic behavior. This paper presents a comprehensive comparative review and analysis of 29 nonlinear dynamics measures for EEG-based sleep stage detection. <b><i>Key Messages:</i></b> The characteristic ranges of these features are reported for the five different sleep stages. All nonlinear measures produce clinically significant results, that is, they can discriminate the individual sleep stages. Feature ranking based on the statistical F-value, however, shows that the third order cumulant of higher order spectra yields the most discriminative result. The distinct value ranges for each sleep stage and the discriminative power of the features can be used for sleep disorder diagnosis, treatment monitoring, and drug efficacy assessment.
Tập 74 Số 5-6 - Trang 268-287 - 2015
Transcranial Magnetic Stimulation for Drug-Resistant Epilepsies: Rationale and Clinical Experience Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique which, over the last 25 years, has greatly expanded from a simple method for stimulating the motor cortex to an invaluable tool with multiple research, diagnostic and even therapeutic applications. In this review, we discuss the use of repetitive TMS as a means of suppressing cortical hyperexcitability in drug-resistant epilepsies. The theoretical background and the experimental evidence in favor of this novel therapeutic approach are presented, and a number of open-label and controlled studies in patients with various forms of focal epilepsy are reviewed. It is concluded that, although the therapeutic effects of repetitive TMS in epilepsy appear rather limited, further clinical testing of this rapidly evolving technology is warranted.
Tập 63 Số 4 - Trang 205-210 - 2010
Thrombolysis with Alteplase 4.5–6 Hours after Acute Ischemic Stroke <i>Background:</i> The safety of intravenous (IV) thrombolysis when administered between 4.5 and 6 h after acute ischemic stroke with alteplase has not been established. <i>Purpose:</i> The objective of this study was to investigate the safety of IV alteplase thrombolysis within a 6-hour time frame following ischemic stroke. <i>Methods:</i>Eligible patients were categorized as having treatment within 4.5 h or from 4.5 to 6 h and were evaluated for the following end points: disability at 90 days as measured by the modified Rankin Scale, incidence of mortality, and type 2 parenchymal hemorrhages. <i>Results:</i> 100 patients were enrolled in our study (58 within 4.5 h after stroke and 42 between 4.5 and 6 h). After 90 days, 47.6% of the patients in the 4.5–6 h group reached independence in comparison to 44.8% patients in the 4.5 h group (p = 0.840). The incidence of type 2 parenchymal hemorrhage in the patients treated between 4.5–6 h and those treated within 4.5 h were 7.1 and 8.6%, respectively (p = 1.00). The incidence of mortality was 7.1 and 17.2% for the 4.5–6 and 4.5 h groups, respectively (p = 0.228). <i>Conclusions:</i> IV thrombolysis in patients who fulfill the NINDS study criteria may still be considered up to 6 h after ischemic stroke.
Tập 65 Số 3 - Trang 170-174 - 2011
Coeliac Disease Presenting with Neurological Disorders It is well known that coeliac disease may be associated with various neurological manifestations. We have had a high index of suspicion of coeliac disease during recent years in our neurological clinic. As a result 10 (7%) out of 144 of our new coeliac patients were detected because of neurological symptoms. The most common neurological manifestations were neuropathy, memory impairment and cerebellar ataxia. In these patient groups screening for coeliac disease with serological antibody tests helps to find patients who may suffer from this disease.
Tập 42 Số 3 - Trang 132-135 - 1999