White Matter Changes in Stroke Patients

European Neurology - Tập 42 Số 2 - Trang 67-75 - 1999
Didier Leys1, Elisabet Englund2, Teodoro del Ser3, Domenico Consoli4, Franz Fazekas5, Natan M. Bornstein6, Timo Erkinjuntti7, John V. Bowler8, Leonardo Pantoni4, Lucilla Parnetti9, Jacques De Reuck10, José M. Ferro11, Julien Bogousslavsky12
1University of Lille, France
2University of Lund, Sweden
3University of Madrid, Spain
4University of Florence, Italy
5University of Graz, Austria
6University of Tel-aviv, Israel
7University of Helsinki, Finland
8Royal Free Hospital, London, UK
9University of Perugia, Italy
10University of Ghent, Belgium
11University of Lisbon, Portugal
12University of Lausanne , Switzerland

Tóm tắt

White matter changes (WMC), detected by imaging techniques, are frequent in stroke patients. The aim of the study was to determine how WMC relate to stroke subtypes and to stroke outcome. We made a systematic Medline search for articles appearing with two of the following key words: either ‘WMC or white matter lesions or leukoencephalopathy or leukoaraiosis’ and ‘stroke or cerebral infarct or cerebral hemorrhage or cerebrovascular disease or transient ischemic attack (TIA)’. WMC, as defined radiologically, are present in up to 44% of patients with stroke or TIA and in 50% of patients with vascular dementia. WMC are more frequent in patients with lacunar infarcts, deep intracerebral hemorrhages, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy and cerebral amyloid angiopathy. After an acute ischemic stroke, WMC are associated with a higher risk of death or dependency, recurrent stroke of any type, cerebral bleeding under anticoagulation, myocardial infarction, and poststroke dementia. WMC in stroke patients are often associated with small-vessel disease and lead to a higher risk of death, and poor cardiac and neurological outcome. However, several questions remain open and need further investigations.

Từ khóa


Tài liệu tham khảo

10.1016/0140-6736(93)91144-B

10.1038/383707a0

10.1016/S0140-6736(95)91557-5

10.1016/0022-510X(92)90124-4

10.1016/0140-6736(91)92916-P

10.1056/NEJM199512143332401

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Thông tin xuất bản

European Neurology

Tập 42 Số 2

67-75

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