European Journal of Pharmacology
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NMDA redox site modulates long-term potentiation of NMDA but not of AMPA receptors
European Journal of Pharmacology - Tập 262 - Trang R3-R4 - 1994
Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors
European Journal of Pharmacology - Tập 554 - Trang 106-112 - 2007
Effects of combined chronic nimodipine and acute metrifonate treatment on spatial and avoidance behavior
European Journal of Pharmacology - Tập 322 - Trang 1 - 1997
The present experiment was designed to elucidate whether chronic dietary treatment with nimodipine (3 months, 1000 ppm) enhances water maze spatial navigation, passive avoidance behavior and locomotor activity, and whether such a treatment with nimodipine would interact with the therapeutic effect of acute metrifonate treatment. In young medial septum-lesioned rats, nimodipine had no effect by its own on cognitive or motor behavior, and did not enhance the water maze and passive avoidance behavior improving action of metrifonate (3 and 10 mg/kg, p.o.). Nimodipine treatment of aged rats did not markedly affect the deficit in motor performance. Single and combined nimodipine and metrifonate (3 and 10 mg/kg, p.o.) treatment of aged rats resulted in shorter escape distance values to the hidden water maze escape platform compared to those of control aged rats. The passive avoidance performance of aged rats was more effectively facilitated by a combined nimodipine and metrifonate treatment than by either of the drugs on their own. Following a washout period of 2.5 months the rats that were treated previously with nimodipine no longer performed better than aged controls in the water maze test. Furthermore, after the washout period metrifonate 10 mg/kg was no longer effective in improving the water maze behavior of the now 26-month-old rats irrespective of their chronic pretreatment. Taken together, these findings indicate that chronic nimodipine and acute metrifonate treatment may more effectively stimulate cognitive functioning than either of the treatments on their own.
#Nimodipine #Metrifonate #Water maze #Passive avoidance #Motor test #Washout #Aged rat #Medial septum-lesioned rat
Possible contribution of β-glucosidase and caspases in the cytotoxicity of glufosfamide in colon cancer cells
European Journal of Pharmacology - Tập 616 - Trang 58-63 - 2009
Insulin-releasing and metabolic effects of small molecule GLP-1 receptor agonist 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline
European Journal of Pharmacology - Tập 628 - Trang 268-273 - 2010
Cyclosporine attenuates the adenylyl cyclase superactivation induced by chronic cannabinoid treatment
European Journal of Pharmacology - Tập 557 - Trang 20-22 - 2007
Low-affinity block of cardiac K+ currents by nifedipine
European Journal of Pharmacology - Tập 401 - Trang 137-143 - 2000
The effects of bosentan, aminoguanidine and l-canavanine on mesenteric blood flow, spleen and liver in endotoxaemic mice
European Journal of Pharmacology - Tập 379 - Trang 73-80 - 1999
Cellular basis for arrhythmogenicity of ionophores with different cation selectivities
European Journal of Pharmacology - Tập 99 - Trang 349-352 - 1984
Berberine modulates gut microbiota to attenuate cerebral ferroptosis induced by ischemia-reperfusion in mice
European Journal of Pharmacology - Tập 953 - Trang 175782 - 2023
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