Triptolide inhibits pancreatic cancer cell proliferation and migration via down-regulating PLAU based on network pharmacology of Tripterygium wilfordii Hook F

Amrutkar, 2017, Pancreatic cancer chemoresistance to gemcitabine, Cancers, 9, 10.3390/cancers9110157 Boezio, 2017, Network-based approaches in pharmacology, Mol. Inform., 36, 10.1002/minf.201700048 Cao, 2018, Beta-sitosterol and gemcitabine exhibit synergistic anti-pancreatic cancer activity by modulating apoptosis and inhibiting epithelial-mesenchymal transition by deactivating akt/GSK-3beta signaling, Front. Pharmacol., 9, 1525, 10.3389/fphar.2018.01525 Chen, 2018, NKX2-2 suppresses osteosarcoma metastasis and proliferation by downregulating multiple target genes, J. Canc., 9, 3067, 10.7150/jca.26382 Chen, 2019, DANCR promotes metastasis and proliferation in bladder cancer cells by enhancing IL-11-STAT3 signaling and CCND1 expression, Mol. Ther., 27, 326, 10.1016/j.ymthe.2018.12.015 Dai, 2019, Triptolide enhances TRAIL sensitivity of pancreatic cancer cells by activating autophagy via downregulation of PUM1, Phytomedicine, 62, 10.1016/j.phymed.2019.152953 Ding, 2015, Triptolide suppresses proliferation, hypoxia-inducible factor-1alpha and c-Myc expression in pancreatic cancer cells, Mol. Med. Rep., 12, 4508, 10.3892/mmr.2015.3960 Fang, 2019, [Hederagenin inhibits proliferation and promotes apoptosis of cervical cancer CaSki cells by blocking STAT3 pathway], Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 35, 140 Feng, 2020, Sequential delivery of nanoformulated alpha-mangostin and triptolide overcomes permeation obstacles and improves therapeutic effects in pancreatic cancer, Biomaterials, 241, 10.1016/j.biomaterials.2020.119907 Gao, 2018, Exploration of methylation-driven genes for monitoring and prognosis of patients with lung adenocarcinoma, Canc. Cell Int., 18, 194, 10.1186/s12935-018-0691-z Hackert, 2016, Borderline resectable pancreatic cancer, Canc. Lett., 375, 231, 10.1016/j.canlet.2016.02.039 Heidarzadeh, 2019, Evaluation of tumor regulatory genes and apoptotic pathways in the cytotoxic effect of cytochalasin H on malignant human glioma cell line (U87MG), Cell J, 21, 62 Huang, 2019, Triptolide exerts an anti-tumor effect on nonsmall cell lung cancer cells by inhibiting activation of the IL6/STAT3 axis, Int. J. Mol. Med., 44, 291 Huang, 2018, Antitumor effect of triptolide in T-cell lymphoblastic lymphoma by inhibiting cell viability, invasion, and epithelial-mesenchymal transition via regulating the PI3K/AKT/mTOR pathway, OncoTargets Ther., 11, 769, 10.2147/OTT.S149788 Jeune, 2019, Pancreatic cancer surgical management, Presse Med., 48, e147, 10.1016/j.lpm.2019.02.027 Kong, 2019, Targeting the oncogene KRAS mutant pancreatic cancer by synergistic blocking of lysosomal acidification and Rapid drug release, ACS Nano, 13, 4049, 10.1021/acsnano.8b08246 Krajnovic, 2016, Versatile antitumor potential of isoxanthohumol: enhancement of paclitaxel activity in vivo, Pharmacol. Res., 105, 62, 10.1016/j.phrs.2016.01.011 Kuchta, 2017, Celastrol, an active constituent of the TCM plant Tripterygium wilfordii Hook.f., inhibits prostate cancer bone metastasis, Prostate Cancer Prostatic Dis., 20, 250, 10.1038/pcan.2017.11 Lee, 2016, Kaempferol inhibits pancreatic cancer cell growth and migration through the blockade of EGFR-related pathway in vitro, PloS One, 11 Li, 2019, Treatment of neurodegenerative diseases with bioactive components of tripterygium wilfordii, Am. J. Chin. Med., 47, 769, 10.1142/S0192415X1950040X Li, 2016, Genetic variations associated with gemcitabine treatment outcome in pancreatic cancer, Pharmacogenetics Genom., 26, 527, 10.1097/FPC.0000000000000241 Li, 2013, Traditional Chinese medicine network pharmacology: theory, methodology and application, Chin. J. Nat. Med., 11, 110, 10.3724/SP.J.1009.2013.00110 Lin, 2019, MicroRNA-193a-3p suppresses the colorectal cancer cell proliferation and progression through downregulating the PLAU expression, Canc. Manag. Res., 11, 5353 Luo, 2019, Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice, Front. Med., 13, 556, 10.1007/s11684-018-0649-5 Luo, 2019, Benefits and safety of tripterygium glycosides and total glucosides of paeony for rheumatoid arthritis: an overview of systematic reviews, Chin. J. Integr. Med., 25, 696, 10.1007/s11655-019-3221-5 Luo, 2013, Pathview: an R/Bioconductor package for pathway-based data integration and visualization, Bioinformatics, 29, 1830, 10.1093/bioinformatics/btt285 Ma, 2019, Triptolide enhances the sensitivity of pancreatic cancer PANC-1 cells to gemcitabine by inhibiting TLR4/NF-kappaB signaling, Am. J. Transl. Res., 11, 3750 Mao, 2016, Tripterygium wilfordii Hook F is efficacious in the treatment of Henoch-Schonlein purpura nephritis in children, World J. Pediatr., 12, 375, 10.1007/s12519-016-0032-z Morales-Oyarvide, 2017, Lymph node metastases in resected pancreatic ductal adenocarcinoma: predictors of disease recurrence and survival, Br. J. Canc., 117, 1874, 10.1038/bjc.2017.349 Noel, 2019, Triptolide and its derivatives as cancer therapies, Trends Pharmacol. Sci., 40, 327, 10.1016/j.tips.2019.03.002 Pei, 2009, FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt, Canc. Cell, 16, 259, 10.1016/j.ccr.2009.07.016 Qi, 2019, Triptolide inhibits the growth and migration of colon carcinoma cells by down-regulation of miR-191, Exp. Mol. Pathol., 107, 23, 10.1016/j.yexmp.2019.01.008 Ritchie, 2015, Limma powers differential expression analyses for RNA-sequencing and microarray studies, Nucleic Acids Res., 43, e47, 10.1093/nar/gkv007 Ru, 2014, TCMSP: a database of systems pharmacology for drug discovery from herbal medicines, J. Cheminf., 6, 13, 10.1186/1758-2946-6-13 Shang, 2018, Retrospective analysis of tacrolimus combined with Tripterygium wilfordii polyglycoside for treating idiopathic membranous nephropathy, BMC Nephrol., 19, 182, 10.1186/s12882-018-0967-5 Siegel, 2018, Cancer statistics, 2018, Ca - Cancer J. Clin., 68, 7, 10.3322/caac.21442 Specht, 2015, Comparison of immunoreactive score, HER2/neu score and H score for the immunohistochemical evaluation of somatostatin receptors in bronchopulmonary neuroendocrine neoplasms, Histopathology, 67, 368, 10.1111/his.12662 Tang, 2018, Celastrol alleviates renal fibrosis by upregulating cannabinoid receptor 2 expression, Cell Death Dis., 9, 601, 10.1038/s41419-018-0666-y Volante, 2007, Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: a proposal of scoring system correlated with somatostatin receptor scintigraphy, Mod. Pathol., 20, 1172, 10.1038/modpathol.3800954 Wu, 2019, Effects of triptolide on bone marrow-derived mesenchymal stem cells from patients with multiple myeloma, Exp. Ther. Med., 17, 3291 Xu, 2018, Expression profile analysis identifies a two-gene signature for prediction of head and neck squamous cell carcinoma patient survival, J. Canc. Res. Therapeut., 14, 1525, 10.4103/jcrt.JCRT_557_18 Yang, 2018, Triptriolide alleviates lipopolysaccharide-induced liver injury by Nrf2 and NF-kappaB signaling pathways, Front. Pharmacol., 9, 999, 10.3389/fphar.2018.00999 Yu, 2015, Celastrol inhibits inflammatory stimuli-induced neutrophil extracellular trap formation, Curr. Mol. Med., 15, 401, 10.2174/1566524015666150505160743 Zhang, 2019, Selective activation of tumor-suppressive MAPKP signaling pathway by triptonide effectively inhibits pancreatic cancer cell tumorigenicity and tumor growth, Biochem. Pharmacol., 166, 70, 10.1016/j.bcp.2019.05.010 Zhang, 2019, Efficacy and safety of Tripterygium wilfordii Hook F preparations for the treatment of Crohn disease: a systemic review and meta-analysis protocol, Medicine (Baltim.), 98