P38 mitogen-activated protein kinase inhibitor SB203580 has a bi-directional effect on iNOS expression and NO production

Alexander, 1999, Suppressors of cytokine signalling (SOCS): negative regulators of signal transduction, J. Leukoc. Biol., 66, 588, 10.1002/jlb.66.4.588 Baldassare, 1999, The role of p38 mitogen-activated protein kinase in IL-1 beta transcription, J. Immunol., 162, 5367, 10.4049/jimmunol.162.9.5367 Bode, 1999, LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages, FEBS Lett., 463, 365, 10.1016/S0014-5793(99)01662-2 Börsch-Haubold, 1998, Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase, J. Biol. Chem., 273, 28766, 10.1074/jbc.273.44.28766 Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem., 72, 248, 10.1016/0003-2697(76)90527-3 Caivano, 1998, Role of MAP kinase cascades in inducing arginine transporters and nitric oxide synthetase in RAW264 macrophages, FEBS Lett., 429, 249, 10.1016/S0014-5793(98)00578-X Chan, 1999, Evaluation of the role of mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFN-gamma and TNF-alpha in mouse macrophages, J. Immunol., 162, 415, 10.4049/jimmunol.162.1.415 Chen, 1999, p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7, Mol. Pharmacol., 55, 481 Chen, 1998, Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway, Science, 280, 1945, 10.1126/science.280.5371.1945 Chu, 1998, Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: characterization of differences between human and mouse iNOS promoters, Biochem. Biophys. Res. Commun., 248, 871, 10.1006/bbrc.1998.9062 Clerk, 1998, The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs), FEBS Lett., 426, 93, 10.1016/S0014-5793(98)00324-X Cuenda, 1995, SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1, FEBS Lett., 364, 229, 10.1016/0014-5793(95)00357-F Faure, 1999, Role of interferon regulatory factor-1 and mitogen-activated protein kinase pathways in the induction of nitric oxide synthase-2 in retinal pigmented epithelial cells, J. Biol. Chem., 274, 4794, 10.1074/jbc.274.8.4794 Garcia, 1998, A mycoplasma fermentans-derived synthetic lipopeptide induces AP-1 and NF-kappaB activity and cytokine secretion in macrophages via the activation of mitogen-activated protein kinase pathways, J. Biol. Chem., 273, 34391, 10.1074/jbc.273.51.34391 Guan, 1997, p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E2 biosynthesis stimulated by interleukin-1beta, J. Biol. Chem., 272, 8083, 10.1074/jbc.272.12.8083 Hall-Jackson, 1999, Effect of SB 203580 on the activity of c-Raf in vitro and in vivo, Oncogene, 18, 2047, 10.1038/sj.onc.1202603 Hanafusa, 1999, Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression, J. Biol. Chem., 274, 27161, 10.1074/jbc.274.38.27161 Jeon, 2000, Radicicol suppresses expression of inducible nitric-oxide synthase by blocking p38 kinase and nuclear factor-kappaB/Rel in lipopolysaccharide-stimulated macrophages, J. Pharmacol. Exp. Ther., 294, 548 Jiang, 1996, Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta), J. Biol. Chem., 271, 17920, 10.1074/jbc.271.30.17920 Jung, 1995, A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion, J. Clin. Invest., 95, 55, 10.1172/JCI117676 Kim, 1997, Upstream NF-kappaB site is required for the maximal expression of mouse inducible nitric oxide synthase gene in interferon-gamma plus lipopolysaccharide-induced RAW 264.7 macrophages, Biochem. Biophys. Res. Commun., 236, 655, 10.1006/bbrc.1997.7031 Kovarik, 1999, Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway, Proc. Natl. Acad. Sci., 96, 13956, 10.1073/pnas.96.24.13956 Kumar, 1997, Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles, Biochem. Biophys. Res. Commun., 235, 533, 10.1006/bbrc.1997.6849 Lähde, 2000, Regulation of nitric oxide production in cultured human T84 intestinal epithelial cells by nuclear factor-kappa B-dependent induction of inducible nitric oxide synthase after exposure to bacterial endotoxin, Aliment. Pharmacol. Ther., 14, 945, 10.1046/j.1365-2036.2000.00781.x Lahti, 2000, Inhibition of extracellular signal-regulated kinase suppresses endotoxin-induced nitric oxide synthesis in mouse macrophages and in human colon epithelial cells, J. Pharmacol. Exp. Ther., 294, 1188 Lee, 1994, A protein kinase involved in the regulation of inflammatory cytokine biosynthesis, Nature, 372, 739, 10.1038/372739a0 Lowenstein, 1993, Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide, Proc. Natl. Acad. Sci., 90, 9730, 10.1073/pnas.90.20.9730 MacMicking, 1997, Nitric oxide and macrophage function, Annu. Rev. Immunol., 15, 323, 10.1146/annurev.immunol.15.1.323 Meja, 2000, p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-kappa B-independent mechanism, Br. J. Pharmacol., 131, 1143, 10.1038/sj.bjp.0703684 Moilanen, 1999, Nitric oxide as a factor in inflammation, 787 Su, 1996, Mitogen-activated protein kinase cascades and regulation of gene expression, Curr. Opin. Immunol., 8, 402, 10.1016/S0952-7915(96)80131-2 Sweet, 1996, Endotoxin signal transduction in macrophages, J. Leukoc. Biol., 60, 8, 10.1002/jlb.60.1.8 Vodovotz, 1993, Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta, J. Exp. Med., 178, 605, 10.1084/jem.178.2.605 Xie, 1993, Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide, J. Exp. Med., 177, 1779, 10.1084/jem.177.6.1779 Young, 1997, Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site, J. Biol. Chem., 272, 12116, 10.1074/jbc.272.18.12116 Zhang, 2000, NF-kappa B regulates the LPS-induced expression of interleukin 12 p40 in murine peritoneal macrophages: roles of PKC, ERK p38 MAPK, and proteasome, Cell. Immunol., 204, 38, 10.1006/cimm.2000.1690