Regulation of PGE2 signaling pathways and TNF-alpha signaling pathways on the function of bone marrow-derived dendritic cells and the effects of CP-25

Bai, 2014, Prostaglandin E2 stimulates Beta 1-integrin expression in hepatocellular carcinoma through the EP1 receptor/PKC/NF-Kappa B pathway, Sci. Rep., 4, R6538, 10.1038/srep06538 Baldwin, 2010, Tumour necrosis factor alpha blockade impairs dendritic cell survival and function in rheumatoid arthritis, Ann. Rheum. Dis., 69, 1200, 10.1136/ard.2009.110502 Blüml, 2012, Targeting TNF receptors in rheumatoid arthritis, Int. Immunol., 24, 275, 10.1093/intimm/dxs047 Cabal-Hierro, 2014, A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1, Oncotarget, 5, 224, 10.18632/oncotarget.1492 Chakraborty, 2014, Modulation of phenotypic and functional maturation of murine bone-marrow-derived dendritic cells (BMDCs) induced by cadmium chloride, Int. Immunopharmacol., 20, 131, 10.1016/j.intimp.2014.02.015 Chang, 2011, Paeoniflorin inhibits function of synoviocytes pretreated by rIL-1α and regulates EP4 receptor expression, J. Ethnopharmacol., 137, 1275, 10.1016/j.jep.2011.07.057 Chen, 2012, Paeoniflorin inhibits proliferation of fibroblast-like synoviocytes through suppressing G-protein-coupled receptor kinase 2, Planta Med., 78, 665, 10.1055/s-0031-1298327 Chen, 2006, Dendritic cell apoptosis in the maintenance of immune tolerance, Science, 311, 1160, 10.1126/science.1122545 Chen, 2010, A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models, Br. J. Pharmacol., 160, 292, 10.1111/j.1476-5381.2010.00647.x Chen, 2006, Tumor necrosis factor-alpha protects synovial cells from nitric oxide induced apoptosis through phosphoinositide 3-kinase Akt signal transduction, J. Rheumatol., 33, 1061 Cho, 2014, Prostaglandin E2 induces IL-6 and IL-8 production by the EP Receptors/Akt/NF-Kappa B Pathways in Nasal Polyp-Derived Fibroblasts, Allergy Asthma Immunol. Res., 6, 449, 10.4168/aair.2014.6.5.449 Dalia, 2014, Dendritic cell and histiocytic neoplasms: biology, diagnosis, and treatment, Cancer Control, 21, 290, 10.1177/107327481402100405 Ding, 2011, TNF receptor 1 mediates dendritic cell maturation and CD8 T cell response through two distinct mechanisms, J. Immunol., 187, 1184, 10.4049/jimmunol.1002902 Fu, 2014, Effect of bone marrow-derived CD11b (+)F4/80 (+) immature dendritic cells on the balance between pro-inflammatory and anti-inflammatory cytokines in DBA/1 mice with collagen-induced arthritis, Inflamm. Res., 63, 357, 10.1007/s00011-014-0707-7 Gagliardi, 2010, Endogenous PGE2 promotes the induction of human Th17 responses by fungal ss-glucan, J. Leukoc. Biol., 88, 947, 10.1189/jlb.0310139 Hao, 2014, PGE(2) EP(3) receptor downregulates COX-2 expression in the medullary thick ascending limb induced by hypertonic NaCl, Am. J. Physiol. Ren. Physiol., 307, 736, 10.1152/ajprenal.00204.2014 Joseph, 2010, Immunologic rheumatic disorders, J. Allergy Clin. Immunol., 125, S204, 10.1016/j.jaci.2009.10.067 Kalim, 2013, Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit, Mol.Immunol., 53, 274, 10.1016/j.molimm.2012.08.014 Kalantari, 2013, Generation of large numbers of highly purified dendritic cells from bone marrow progenitor cells after co-culture with syngeneic murine splenocytes, Exp. Mol. Pathol., 94, 336, 10.1016/j.yexmp.2012.12.001 Kollias, 2005, TNF pathophysiology in murine models of chronic inflammation and autoimmunity, Semin. Arthritis Rheum., 34, 3, 10.1016/j.semarthrit.2005.01.002 Krause, 2009, Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells, Blood, 113, 2451, 10.1182/blood-2008-05-157123 Moelants, 2013, Regulation of TNF-α with a focus on rheumatoid arthritis, Immunol. Cell Biol., 91, 393, 10.1038/icb.2013.15 Mathieu, 2008, Mutual antagonistic relationship between prostaglandin E(2) and IFN-gamma: implications for rheumatoid arthritis, Eur. J. Immunol., 38, 1900, 10.1002/eji.200838170 Maney, 2014, Dendritic Cell Maturation And Survival Are Differentially Regulated by TNFR1 and TNFR2, J. Immunol., 193, 4914, 10.4049/jimmunol.1302929 Mariana, 2011, The role of Tumor Necrosis Factor-alpha (TNF-α) in the pathogenesis of systemic lupus erythematosus, Cytokine, 56, 537, 10.1016/j.cyto.2011.08.026 Maślanka, 2014, Prostaglandin E2 down-regulates the expression of CD25 on bovine T cells, and this effect is mediated through the EP4 receptor, Vet. Immunol. Immunopathol., 160, 192, 10.1016/j.vetimm.2014.05.003 McDevitt, 2002, Multiple roles for tumor necrosis factor-alpha and lymphotoxin alpha/beta in immunity and autoimmunity, Arthritis Res., 4, S141, 10.1186/ar570 Monk, 2014, Antagonizing arachidonic acid-derived eicosanoids reduces inflammatory Th17 and Th1 cell-mediated inflammation and colitis severity, Mediat. Inflamm., 2014, R917149, 10.1155/2014/917149 Raghav, 2006, Expression of TNF-alpha and related signaling molecules in the peripheral blood mononuclear cells of rheumatoid arthritis patients, Mediat. Inflamm., 2006, R12682 Sun, 2011, Non-canonical NF-κB signaling pathway, Cell Res., 21, 71, 10.1038/cr.2010.177 Svajger, 2010, Dendritic cells treated with resveratrol during differentiation from monocytes gain substantial tolerogenic properties upon activation, Immunology, 129, 525, 10.1111/j.1365-2567.2009.03205.x Tsuboi, 2004, Paeoniflorin induces apoptosis of lymphocytes through a redoxlinked mechanism, J. Cell. Biochem., 93, 162, 10.1002/jcb.20134 Wang, 2012, Paeoniflorin inhibits function and down-regulates HLA-DR and CD80 expression of human peripheral blood monocytes stimulated by rhIL-1β, Int. Immunopharmacol., 14, 172, 10.1016/j.intimp.2012.07.005 Wang, 2013, Paeoniflorin inhibits inflammatory responses in mice with allergic contact dermatitis by regulating the balance between inflammatory and anti-inflammatory cytokines, Inflamm. Res., 62, 1035, 10.1007/s00011-013-0662-8 Wang, 2013, Maturation of murine bone marrow dendritic cells induced by acidic Ginseng polysaccharides, Int. J. Biol. Macromol., 53, 93, 10.1016/j.ijbiomac.2012.11.009 Wang, 2014, Study on paeoniflorin-6′O-benzenesulfonate sphysicochemical property, Acta Univ. Med. Anhui, 49, 202 Wu, 2014, Assaying NF-κB activation and signaling from TNF receptors, Methods Mol. Biol., 1155, 1, 10.1007/978-1-4939-0669-7_1 Xia, 2014, Prostaglandin E2 promotes the cell growth and invasive ability of hepato-cellular carcinoma cells by up-regulating c-Myc expression via EP4 receptor and the PKA signaling pathway, Oncol. Rep., 32, 1521, 10.3892/or.2014.3393 Zhang, 2008, Paeoniflorin suppresses inflammatory mediator production and regulates G protein-coupled signaling in fibroblast-like synoviocytes of collagen induced arthritic rats, Inflamm. Res., 57, 388, 10.1007/s00011-007-7240-x