European Journal of Immunology

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Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin
European Journal of Immunology - Tập 23 Số 4 - Trang 935-942 - 1993
Doron Melamed, Aharon Friedman
AbstractThe present study investigated bystander suppression, specific suppression and anergy as mechanisms for oral tolerance. Oral tolerance was induced in mice by a single gastric intubation of 20 mg ovalbumin (OVA) and was evaluated in vitro by the absence of T lymphocyte proliferative responses to OVA after priming by OVA‐complete Freund's adjuvant (CFA). T lymphocyte unresponsiveness was ant... hiện toàn bộ
Granulocytic myeloid derived suppressor cells expand in human pregnancy and modulate T‐cell responses
European Journal of Immunology - Tập 44 Số 9 - Trang 2582-2591 - 2014
Natascha Köstlin‐Gille, Hellen Kugel, Bärbel Spring, Anja Leiber, Alexander Marmé, Melanie Henes, Nikolaus Rieber, Dominik Hartl, Christian F. Poets, Christian Gille
Immune tolerance toward the semiallogeneic fetus plays a crucial role in the maintenance of pregnancy. Myeloid‐derived suppressor cells (MDSCs) are innate immune cells characterized by their ability to modulate T‐cell responses. Recently, we showed that MDSCs accumulate in cord blood of healthy newborns, yet their role in materno–fetal tolerance remained elusive. In the present study, we demonstra... hiện toàn bộ
Human neonatal thymectomy induces altered B‐cell responses and autoreactivity
European Journal of Immunology - Tập 47 Số 11 - Trang 1970-1981 - 2017
Theo van den Broek, Asaf Madi, Eveline M. Delemarre, Alvin Schadenberg, Kiki Tesselaar, José A. M. Borghans, Stefan Nierkens, Frank A. Redegeld, Henny G. Otten, Maura Rossetti, Salvatore Albani, Rachel Sorek, Irun R. Cohen, Nicolaas J. G. Jansen, Femke van Wijk
AbstractAn association between T‐cell lymphopenia and autoimmunity has long been proposed, but it remains to be elucidated whether T‐cell lymphopenia affects B‐cell responses to autoantigens. Human neonatal thymectomy (Tx) results in a decrease in T‐cell numbers and we used this model to study the development of autoreactivity. Two cohorts of neonatally thymectomized individuals were examined, a c... hiện toàn bộ
Diversity of T cell receptor α and β chain genes expressed by human T cells specific for similar myelin basic protein peptide/major histocompatibility complexes
European Journal of Immunology - Tập 22 Số 3 - Trang 753-758 - 1992
Gerhard Giegerich, M. Pette, Edgar Meinl, Jörg T. Epplen, H. Wekerle, Ari Hinkkanen
AbstractT cell receptor (TcR) α and β nucleotide sequences involved in the human autoreactivity to myelin basic protein (MBP) were studied by screening cDNA libraries derived from 11 independent T lymphocyte clones (TCC) established from multiple sclerosis patients and healthy donors. The TCC with defined MBP peptide specificity and HLA‐DR restriction expressed multiple TcR. Even TCC recognizing t... hiện toàn bộ
Clonal analysis of immunoglobulin mRNA in rheumatoid arthritis synovium: Characterization of expanded IgG3 populations
European Journal of Immunology - Tập 27 Số 2 - Trang 476-485 - 1997
David G. Williams, Peter C. Taylor
AbstractPlasma cells secreting IgG, M, and A abound in the synovium of patients with rheumatoid arthritis, yet their immunoglobulin repertoire and clonal relationship remain to be elucidated. Locally synthesized immunoglobulins probably contribute to the chronic joint inflammatory processes which are characteristic of these patients. To determine whether B lymphocyte proliferation contributes to t... hiện toàn bộ
Interferon regulatory factor‐1 gene deletion decreases glomerulonephritis in MRL/lpr mice
European Journal of Immunology - Tập 36 Số 5 - Trang 1296-1308 - 2006
Christopher M. Reilly, Selen Olgun, David G. Goodwin, Robert M. Gogal, Arben Santo, Jason W. Romesburg, S. Ansar Ahmed, Gary S. Gilkeson
AbstractTo investigate the role of interferon regulatory factor‐1 (IRF‐1) in the development of lupus nephritis, IRF‐1–/– genotype mice were bred onto the MRL/lpJfaslpr (MRL/lpr) background. We examined kidney mesangial cell function and disease progression. Endpoints evaluated included inflammatory mediators, autoantibody production, immune complex deposition, renal pathology, T cell subset analy... hiện toàn bộ
Interferon‐γ‐inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin‐12 for interferon‐γ production
European Journal of Immunology - Tập 26 Số 7 - Trang 1647-1651 - 1996
Mark Micallef, Takashi Ohtsuki, Keizo Kohno, Fujimi Tanabe, Shimpei Ushio, Motoshi Namba, Tadao Tanimoto, Kakuji Torigoe, Mitsukiyo Fujii, Masao Ikeda, Shigeharu Fukuda, Masashi Kurimoto
AbstractThe novel cytokine interferon‐γ‐inducing factor (IGIF) augments natural killer (NK) cell activity in cultures of human peripheral blood mononuclear cells (PBMC), similarly to the structurally unrelated cytokine interleukin (IL)‐12. IGIF has been found to enhance the production of interferon‐γ (IFN‐γ) and granulocyte/macrophage colony‐stimulating factor (GM‐CSF) while inhibiting the product... hiện toàn bộ
Cytotoxic T cell responses to haptenated cells III. Isolation and specificity analysis of continuously growing clones
European Journal of Immunology - Tập 10 Số 11 - Trang 828-834 - 1980
Werner Haas, Jacqueline Mathur‐Rochat, Helmut M. Pohlit, Markus Nabholz, Harald von Boehmer
AbstractVarious procedures were used to derive continuously growing cytotoxic T lymphocyte (CTL) clones from a primary culture containing responder cells from immunized mice and 3‐(p‐sulfophenyldiazo)‐4‐hydroxylphenyl acetic acid (SP)‐or fluorescein isothiocyanate (FL)‐coupled stimulator cells. It seems likely that CTL have to undergo some change, possibly genetic, to be able to grow continuously ... hiện toàn bộ
The role of the left end of the H‐2b haplotype in the male‐specific cytotoxic T cell response
European Journal of Immunology - Tập 9 Số 11 - Trang 913-915 - 1979
Harald von Boehmer, Kathrin Turton, Werner Haas
AbstractThe male‐specific cytotoxic T cell response was tested in various mouse strains. We found that priming with lo7 nonirradiated or 2 × 107 X‐irradiated cells (2000 Rad) was similarly effective in B 6 mice. We have avoided possible allogeneic effects due to priming F1 hybrids with parental cells and tested all mice after the same time interval for generation of male‐specific cytotoxic T lymph... hiện toàn bộ
Selection of the T cell repertoire during ontogeny: Limiting dilution analysis
European Journal of Immunology - Tập 12 Số 10 - Trang 887-892 - 1982
Hung‐Sia Teh, Jack R. Bennink, Harald von Boehmer
AbstractThe relative frequencies of cytotoxic T lymphocyte precursors (CTL‐P) specific for minor histocompatibility antigens that are restricted to either k or b major histocompatibility complex antigens in normal B6 mice and in B6 → (B6 CBA)F1 radiation chimeras were estimated. The ratio of k‐restricted to b‐restricted CTL‐P determined for the radiation chimeras served as a base value to which th... hiện toàn bộ
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