Diversity of T cell receptor α and β chain genes expressed by human T cells specific for similar myelin basic protein peptide/major histocompatibility complexes

European Journal of Immunology - Tập 22 Số 3 - Trang 753-758 - 1992
Gerhard Giegerich1,2, M. Pette1,2, Edgar Meinl1, Jörg T. Epplen3,1,4, H. Wekerle1, Ari Hinkkanen5,1
1Department of Neuroimmunology, Max-Planck Institute for Psychiatry, Martinsried
2Department of Neurology, University of Würzburg, W-8700 Würzburg, FRG
3Department of Molecular Human Genetics, University of Bochum
4W-4630 Bochum 1, FRG
5Department of Medical Virology, University of Turku, Kiinanmyllynkatu 13, SF-20520 Turku 52, Finland

Tóm tắt

AbstractT cell receptor (TcR) α and β nucleotide sequences involved in the human autoreactivity to myelin basic protein (MBP) were studied by screening cDNA libraries derived from 11 independent T lymphocyte clones (TCC) established from multiple sclerosis patients and healthy donors. The TCC with defined MBP peptide specificity and HLA‐DR restriction expressed multiple TcR. Even TCC recognizing the same human MBP peptide [amino acids (aa) 139–153] in identical or very similar HLA‐DR context expressed diverse TcR. Two TCC which recognized peptide aa 139–153 equally well in the context of both HLA‐DR2a and ‐DR1 molecules used distinct TcR α but identical β chains.The knowledge of TcR β and TcR α chain sequences of human MBP‐specific T cells will allow studies correlating structure and function of TcR and their targets in MBP autoreactivity. This may have an impact on the development of immunotherapies in multiple sclerosis.

Từ khóa


Tài liệu tham khảo

10.1016/0092-8674(89)90044-5

10.1038/334395a0

10.1111/j.1600-065X.1988.tb00736.x

10.1084/jem.168.3.1081

10.1084/jem.166.2.583

10.1084/jem.165.2.279

10.1016/0092-8674(88)90558-2

10.1016/0092-8674(88)90079-7

10.1002/eji.1830190210

10.1084/jem.169.1.27

10.1016/0167-5699(89)90174-6

10.1038/341541a0

10.1126/science.2814489

10.1084/jem.171.6.1943

10.1084/jem.167.5.1586

10.1002/jnr.490230211

10.1016/0165-5728(89)90073-8

10.1038/346183a0

10.1016/0008-8749(90)90197-Y

Martin R., 1990, J. Immunol., 145, 540, 10.4049/jimmunol.145.2.540

10.1212/WNL.40.11.1770

10.1073/pnas.87.20.7968

10.1002/eji.1830210610

10.1007/978-1-4613-8545-5_8

10.1111/j.1749-6632.1965.tb20235.x

10.1007/BF00210448

10.1021/bi00591a005

10.1007/BF00395864

10.1073/pnas.74.12.5463

10.1002/eji.1830210412

10.1002/eji.1830210411

10.1016/0167-5699(90)90148-3

10.1126/science.1693015

10.1038/345344a0

10.1016/0167-5699(91)90126-E

10.1073/pnas.88.6.2466

10.1084/jem.173.1.19

10.1002/ana.410290312

10.1002/jnr.490280215

Meinl E., 1991, Neurology, 43, 257

10.1007/BF00216697

Jaraquemada D., 1990, J. Immunol., 145, 2880, 10.4049/jimmunol.145.9.2880

Kourilsky P., 1989, Immunol., 45, 107

10.1002/eji.1830210910

Wucherpfennig J., 1991, FASEB J., 5, A1384

10.1002/eji.1830210323

10.1073/pnas.85.22.8608

10.1073/pnas.88.18.8077

10.1002/eji.1830170312

10.1073/pnas.84.19.6884

10.1002/j.1460-2075.1988.tb02993.x

10.1073/pnas.83.17.6598

10.1073/pnas.82.24.8624

10.1073/pnas.88.20.9161

Thông tin
Thông tin xuất bản

European Journal of Immunology

Tập 22 Số 3

753-758

Thông tin tác giả