Natascha Köstlin‐Gille1, Hellen Kugel1, Bärbel Spring1, Anja Leiber1, Alexander Marmé2, Melanie Henes3, Nikolaus Rieber4, Dominik Hartl4, Christian F. Poets1, Christian Gille1
1Department of Neonatology, Tuebingen University Children’s Hospital, Tuebingen, Germany
2Am Lustnauer Tor 4, Tuebingen, Germany
3Department of Obstetrics and Gynecology, Tuebingen University Hospital, Tuebingen, Germany
4Department of Pediatrics I, Tuebingen University Children's Hospital, Tuebingen, Germany
Tóm tắt
Immune tolerance toward the semiallogeneic fetus plays a crucial role in the maintenance of pregnancy. Myeloid‐derived suppressor cells (MDSCs) are innate immune cells characterized by their ability to modulate T‐cell responses. Recently, we showed that MDSCs accumulate in cord blood of healthy newborns, yet their role in materno–fetal tolerance remained elusive. In the present study, we demonstrate that MDSCs with a granulocytic phenotype (GR‐MDSCs) are highly increased in the peripheral blood of healthy pregnant women during all stages of pregnancy compared with nonpregnant controls, whereas numbers of monocytic MDSCs were unchanged. GR‐MDSCs expressed the effector enzymes arginase‐I and iNOS, produced high amounts of ROS and efficiently suppressed T‐cell proliferation. After parturition, GR‐MDSCs decreased within a few days. In combination, our results show that GR‐MDSCs expand in normal human pregnancy and may indicate a role for MDSCs in materno–fetal tolerance.
