Harald von Boehmer1, Kathrin Turton1, Werner Haas1
1Basel Institute for Immunology, Basel
Tóm tắt
AbstractThe male‐specific cytotoxic T cell response was tested in various mouse strains. We found that priming with lo7 nonirradiated or 2 × 107 X‐irradiated cells (2000 Rad) was similarly effective in B 6 mice. We have avoided possible allogeneic effects due to priming F1 hybrids with parental cells and tested all mice after the same time interval for generation of male‐specific cytotoxic T lymphocytes in vitro. Under these conditions, we found an absolute requirement for H‐2b gene products, encoded left of B, in order to see male‐specific responses.
