European Journal of Clinical Investigation

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Bile acid profiles in urine of patients with liver diseases
European Journal of Clinical Investigation - Tập 9 Số 5 - Trang 341-348 - 1979
A. Bremmelgaard, Jan Sjövall
Abstract. Quantitative gas chromatography‐mass spectrometry was used to study the metabolic profiles of unconjugated, conjugated and sulphated bile acids in urine of patients with intermittent intrahepatic cholestasis of unknown aetiology, cirrhosis of the liver, primary biliary cirrhosis, viral and toxic hepatitis and extrahepatic cholestasis.A lar...... hiện toàn bộ
The Effect of Spironolactone on Transport of Na+., K+ and H+. A Microperfusion Study in Rat Main Submaxillary Duct*
European Journal of Clinical Investigation - Tập 6 Số 1 - Trang 17-20 - 1976
H. Knauf, K. Pander, Stéphane Franck
The epithelium of the main excretory duct of the rat submaxillary gland was used as a target tissue for studies on the effect of a spironolactone on electrolyte transport. The spironolactone decreased net Na+ reabsorption by 27 % and net K+ secretion by 23 %. HCO3 was found to be about 2‐fold accumulated in the duct lumen, which was considered to r...... hiện toàn bộ
Increased biosynthesis of thromboxane A2 by diabetic platelets
European Journal of Clinical Investigation - Tập 9 Số 3 - Trang 223-228 - 1979
Vincent A. Ziboh, Hiroyuki Maruta, Jonathan T. Lord, WILLIAM D. CAGLE, WILLIAM LUCKY
Abstract. Because ADP has been reported to produce a secondary wave of platelet aggregation in diabetic subjects, and since ADP is known to enhance normal platelet biosynthesis of pro‐aggregating thromboxane A2, we tested whether or not the reported increased sensitivity of diabetic platelets to ADP may also result in increased platelet biosynth...... hiện toàn bộ
Demonstration in Serum of two Physiological Forms of the Human Retinol Binding Protein*
European Journal of Clinical Investigation - Tập 1 Số 6 - Trang 437-444 - 1971
P A Peterson
Abstract. The contents of prealbumin, retinol binding protein, and retinol in normal human serum have been estimated. The amounts of prealbumin were, on average, 6 times larger than those of RBP, that is a two‐fold molar excess of prealbumin over RBP. Retinol and RBP were present in about the same molar amounts. Prealbumin occurred in two molecular forms in serum. A...... hiện toàn bộ
Distribution of diacylglycerols among plasma lipoproteins in control subjects and in patients with non‐insulin‐dependent diabetes
European Journal of Clinical Investigation - Tập 29 Số 2 - Trang 139-144 - 1999
Florent Lalanne, V. Pruneta, Sophie Bernard, Gabriel Ponsin
BackgroundDiacylglycerols (DAGs), which are well‐known components of insect lipophorins, have been recently recognized as a major glyceride of human high‐density lipoprotein (HDL). Moreover, DAGs are good substrates for hepatic lipase and for the phospholipid transfer protein (PLTP). The present work was undertaken to determine the lipoprotein concentrati...... hiện toàn bộ
Localization of collagen mRNA in normal and scleroderma skin by in‐situ hybridization
European Journal of Clinical Investigation - Tập 18 Số 1 - Trang 9-17 - 1988
Karin Scharffetter, Brigitte Lankat‐Buttgereit, Thomas Krieg
Abstract. Scleroderma is a fibrotic disease occurring in a localized or systemic form. Disturbed regulation of connective tissue metabolism plays an important role in its pathogenesis. However, until now, most of the data available were obtained from studies of fibroblasts in culture and there is considerable doubt that fibroblasts in a monolayer reflect the ... hiện toàn bộ
Ethanol decreases plasma sulphydryls in man: effect of disulfiram
European Journal of Clinical Investigation - Tập 18 Số 4 - Trang 420-424 - 1988
Jean‐Marc Burgunder, Joachim Nelles, M Bilzer, Bernhard H. Lauterburg
Abstract Based on animal experiments, interactions of ethanol and its metabolites with sulphydryls have been implicated in the toxicity of ethanol, but acute effects of ethanol on sulphydryls have not been documented in man. Plasma free glutathione and cysteine were therefore measured following the administration of 0·2 g kg‐1ethanol to normal he...... hiện toàn bộ
Lipid and carbohydrate metabolism in uraemia
European Journal of Clinical Investigation - Tập 9 Số 4 - Trang 285-291 - 1979
Per‐Ola Attman, A. Gustafson
Abstract.Lipid and carbohydrate metabolism variables were studied in twenty‐eight patients with chronic renal failure (mean GFR 7.7 ± 2.5 ml/min) and uraemic symptoms.71% of the patients had hypertriglyceridaemia (≥ 2.2 mmol/l). Total serum cholesterol was normal while VLDL cholesterol was high and α‐lipoprotein cholesterol was low. The fractional el...... hiện toàn bộ
Increased frequency of late pre‐β lipoproteins (LP β) in isolated serum very low density lipoproteins in uraemia
European Journal of Clinical Investigation - Tập 10 Số 6 - Trang 423-426 - 1980
Hans Erik Norbeck, Lars A. Carlson
Abstract. Hypertriglyceridaemia, which is caused by raised levels of the triglyceride rich serum very low density lipoproteins (VLDL), is common in uraemia. Here we report qualitative studies on VLDL in this condition. VLDL were isolated from serum of 137 uraemic patients by ultracentrifugation, subjected to agarose electrophoresis and stained for lipids. An increas...... hiện toàn bộ
Role of glucocorticoid receptor polymorphism in adrenal incidentalomas
European Journal of Clinical Investigation - Tập 40 Số 9 - Trang 803-811 - 2010
Valentina Morelli, F Donadio, Cristina Eller-Vainicher, Valentina Cirello, Luca Olgiati, Chiara Savoca, Elisa Cairoli, Antonio Stefano Salcuni, Paolo Beck‐Peccoz, Iacopo Chiodini
Eur J Clin Invest 2010; 40 (9): 803–811AbstractBackground  Adrenal incidentalomas (AI) have been associated with and an increased prevalence of metabolic and bone complications. The N363S and BclI polymorphisms of the glucocorticoid receptor (GR) have bee...... hiện toàn bộ
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