European Journal of Clinical Investigation

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COVID‐19 vaccination in children and university students
European Journal of Clinical Investigation - Tập 51 Số 11 - 2021
John P. A. Ioannidis
AbstractStrategies for the use of COVID‐19 vaccines in children and young adults (in particular university students) are hotly debated and important to optimize. As of late August 2021, recommendations on the use of these vaccines in children vary across different countries. Recommendations are more uniform for vaccines in young adults, but vaccination uptake in th...... hiện toàn bộ
Aprotinin treatment against SARS‐CoV‐2: A randomized phase III study to evaluate the safety and efficacy of a pan‐protease inhibitor for moderate COVID‐19
European Journal of Clinical Investigation - Tập 52 Số 6 - 2022
Francisco Javier Redondo Calvo, Juan Fernando Padín, José Ramón Muñoz‐Rodríguez, Leticia Serrano‐Oviedo, Pilar López‐Juárez, María Lourdes Porras Leal, Francisco Javier González Gasca, Marta Rodríguez Martínez, Raúl Pérez Serrano, Abraham Sánchez Cadena, Natalia Bejarano, Constanza Muñoz Hornero, José Ramón Barberá Farré, Inmaculada Domínguez‐Quesada, María A. Sepúlveda Berrocal, María Dolores Villegas Fernández‐Infantes, María Isabel Manrique Romo, A Comino, José Manuel Pérez‐Ortiz, Francisco Javier Gómez‐Romero
AbstractBackgroundSARS‐CoV‐2 virus requires host proteases to cleave its spike protein to bind to its ACE2 target through a two‐step furin‐mediated entry mechanism. Aprotinin is a broad‐spectrum protease inhibitor that has been employed as antiviral drug for other human respiratory viruses. Also, it has important anti‐inflammatory...... hiện toàn bộ
Creatine corrects muscle 31P spectrum in gyrate atrophy with hyperornithinaemia
European Journal of Clinical Investigation - Tập 29 Số 12 - Trang 1060-1065 - 1999
Heinänen, Näntö‐Salonen, Komu, Erkintalo, Alanen, Olli J. Heinonen, Kari Pulkki, Nikoskelainen, Sipilä, Simell
BackgroundEye fundus destruction and type II muscle fiber atrophy in gyrate atrophy of the choroid and retina with hyperornithinaemia (GA) may be mediated by elevated ornithine concentrations which strongly inhibit creatine biosynthesis. This results in deficiency of creatine phosphate (PCr), a key intracellular energy source, as we have demonstrated in s...... hiện toàn bộ
Effects of chlorpromazine hydrochloride on bile salt synthesis, bile formation and biliary lipid secretion in the Rhesus monkey: a model for chlorpromazine‐induced cholestasis
European Journal of Clinical Investigation - Tập 9 Số 1 - Trang 29-41 - 1979
Emilio Ros, Donald Small, Martin C. Carey
Abstract. We studied the acute effects of intravenous infusions of chlorpromazine hydrochloride on bile salt synthesis, bile formation and biliary lipid secretion in the alert female Rhesus monkey prepared with a total biliary fistula and in a steady bile salt secretory state. In twelve studies (three animals), five doses of radio‐labelled chlorpromazine hydrochlori...... hiện toàn bộ
Autonomic dysfunction and upper digestive functional disorders in untreated adult coeliac disease
European Journal of Clinical Investigation - Tập 27 Số 12 - Trang 1009-1015 - 1997
Paolo Usai, Paolo Usai‐Satta, Maria Letizia Lai, M Corda, Enrico Piras, Calcedonio Calcara, M. F. Boy, Andrea Morelli, A Balestrieri, Gabrio Bassotti
There is recent evidence that upper‐gut motor abnormalities may be present in coeliac disease. However, to date, the pathophysiological mechanisms responsible for the above have not been explored. The purpose of the present study was to investigate upper‐gut motor activity in coeliac disease and explore the role played by the autonomic nervous system in motility disturbances. Thirty untrea...... hiện toàn bộ
The metabolic syndrome: metabolic changes with vascular consequences
European Journal of Clinical Investigation - Tập 37 Số 1 - Trang 8-17 - 2007
Annemarie M.J. Wassink, Jobien K. Olijhoek, Frank L.J. Visseren
AbstractDespite criticism regarding its clinical relevance, the concept of the metabolic syndrome improves our understanding of both the pathophysiology of insulin resistance and its associated metabolic changes and vascular consequences. Free fatty acids (FFA) and tumour necrosis factor‐alpha (TNF‐α) play prominent roles in the development of insulin resistance by...... hiện toàn bộ
COVID‐19 diagnosis does not rule out other concomitant diseases
European Journal of Clinical Investigation - Tập 50 Số 6 - 2020
Alberto Borghetti, Arturo Ciccullo, Elena Visconti, Enrica Tamburrini, Simona Di Giambenedetto
Identification of steroid receptors in human adipose tissue
European Journal of Clinical Investigation - Tập 26 Số 12 - Trang 1051-1056 - 1996
Steen B. Pedersen, S. FUGLSIG, Per Sjøgren, Bjørn Richelsen
Steroids have the ability to alter adipose tissue distribution. Controversy exists as to whether these effects of sex hormones (oestrogen, progesterone and testosterone) on human adipose tissue are indirect or direct, as only very few studies have focused on steroid receptor status in human adipose tissue. In the present study, we reinvestigated steroid receptor status in human mature adip...... hiện toàn bộ
Microgravity inhibits intestinal calcium absorption as shown by a stable strontium test
European Journal of Clinical Investigation - Tập 30 Số 12 - Trang 1036-1043 - 2000
Armin Zittermann, Martina Heer, A. Caillot‐Augusso, Petra Rettberg, K. Scheld, C. Drummer, C Alexandre, G. Horneck, D. Vorobiev, Peter Stehle
Little is known about the onset and degree of biochemical and functional alterations in calcium metabolism during microgravity.To evaluate the effect of microgravity on intestinal calcium absorption and calcium‐regulating hormones under metabolic ward conditions.Fractional calcium absorption (Fc240 in percentage of dose administered) w...... hiện toàn bộ
STrengthening the REporting of Genetic Association studies (STREGA) – an extension of the STROBE statement
European Journal of Clinical Investigation - Tập 39 Số 4 - Trang 247-266 - 2009
Julian Little, Julian P. T. Higgins, John P. A. Ioannidis, David Moher, France Gagnon, Erik von Elm, Muin J. Khoury, Barbara Cohen, George Davey Smith, Jeremy Grimshaw, Paul Scheet, Marta Gwinn, Robin E. Williamson, Guangyong Zou, Kim Hutchings, Candice Y. Johnson, Valerie Tait, Miriam Wiens, Jean Golding, Cornelia M. van Duijn, John McLaughlin, Andrew D. Paterson, George A. Wells, Isabel Fortier, Matthew L. Freedman, Maja Zečević, Richard King, Claire Infante‐Rivard, Alexandre F.R. Stewart, Nick Birkett
AbstractMaking sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting...... hiện toàn bộ
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