European Journal of Clinical Investigation

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Bile acid profiles in urine of patients with liver diseases
European Journal of Clinical Investigation - Tập 9 Số 5 - Trang 341-348 - 1979
A. Bremmelgaard, Jan Sjövall
Abstract. Quantitative gas chromatography‐mass spectrometry was used to study the metabolic profiles of unconjugated, conjugated and sulphated bile acids in urine of patients with intermittent intrahepatic cholestasis of unknown aetiology, cirrhosis of the liver, primary biliary cirrhosis, viral and toxic hepatitis and extrahepatic cholestasis.A large number of bile acids was present which can bro... hiện toàn bộ
Modulation of platelet and monocyte function by the chemokine fractalkine (CX3CL1) in cardiovascular disease
European Journal of Clinical Investigation - Tập 45 Số 6 - Trang 624-633 - 2015
Ulrike Flierl, Johann Bauersachs, Andreas Schäfer
AbstractBackgroundThe chemokine fractalkine, CX3CL1, bears unique features within the chemokine family: it exists in a membrane bound form acting as an adhesion molecule and surface receptor; however, when cleaved by ADAM 10, it functions as a soluble chemokine. Fractalkine and its chemokine receptor CX3CR1 are known to have multiple roles in diverse human diseases, for example inflammatory diseas... hiện toàn bộ
Chemotaxis of the peritoneal cells and the detection of a chemo‐attractant in the effluent from peritoneal dialysis patients
European Journal of Clinical Investigation - Tập 20 Số s1 - Trang 555-562 - 1990
H J Bos, D. M. Boorsma, Cornelis W. Tuk, J. C. de Veld, A. J. C. VAN DER MUYSENBERG, T J Helmerhorst, Dirk G. Struijk, H van Bronswijk, R.H.J. Beelen
Abstract. The migration of peritoneal cells from 25 continuous ambulatory peritoneal dialysis patients and eight healthy women undergoing laparoscopy were studied. Peritoneal cells of continuous ambulatory peritoneal dialysis patients migrated to commonly used chemoattractants, like N‐formyl‐methionyl‐leu‐cyl‐phenyl‐alanine‐methyl‐ester and casein, but they also migrated to high concentrations of ... hiện toàn bộ
The Effect of Spironolactone on Transport of Na+., K+ and H+. A Microperfusion Study in Rat Main Submaxillary Duct*
European Journal of Clinical Investigation - Tập 6 Số 1 - Trang 17-20 - 1976
H. Knauf, K. Pander, Stéphane Franck
The epithelium of the main excretory duct of the rat submaxillary gland was used as a target tissue for studies on the effect of a spironolactone on electrolyte transport. The spironolactone decreased net Na+ reabsorption by 27 % and net K+ secretion by 23 %. HCO3 was found to be about 2‐fold accumulated in the duct lumen, which was considered to result from decreased H+ion secretion. The results ... hiện toàn bộ
The metabolic syndrome: metabolic changes with vascular consequences
European Journal of Clinical Investigation - Tập 37 Số 1 - Trang 8-17 - 2007
Annemarie M.J. Wassink, Jobien K. Olijhoek, Frank L.J. Visseren
AbstractDespite criticism regarding its clinical relevance, the concept of the metabolic syndrome improves our understanding of both the pathophysiology of insulin resistance and its associated metabolic changes and vascular consequences. Free fatty acids (FFA) and tumour necrosis factor‐alpha (TNF‐α) play prominent roles in the development of insulin resistance by impairing the intracellular insu... hiện toàn bộ
Effect of endothelin‐1 on intracellular glutathione and lipid peroxide availability and on the secretion of vasoactive substances by human umbilical vein endothelial cells
European Journal of Clinical Investigation - Tập 32 Số 8 - Trang 556-562 - 2002
Fortunato Scalera, Ralf Dittrich, Matthias W. Beckmann, Ernst Beinder
AbstractBackground The major pathophysiologic changes observed in preeclampsia suggest that endothelial cell dysfunction plays an important role in this disorder. The pathway mediating endothelial cell layer dysfunction is unknown. The concentration of endothelin‐1 (ET‐1), a potent mammalian vasoconstrictor peptide produced by the vascular endothelium, has been observed to be significantly increas... hiện toàn bộ
Elastic tissue abnormalities in inherited haemolytic syndromes
European Journal of Clinical Investigation - Tập 32 Số 9 - Trang 640-642 - 2002
Athanasios Aessopos, Dimitrios Farmakis, Evangelos Terpos
Increased biosynthesis of thromboxane A2 by diabetic platelets
European Journal of Clinical Investigation - Tập 9 Số 3 - Trang 223-228 - 1979
Vincent A. Ziboh, Hiroyuki Maruta, Jonathan T. Lord, WILLIAM D. CAGLE, WILLIAM LUCKY
Abstract. Because ADP has been reported to produce a secondary wave of platelet aggregation in diabetic subjects, and since ADP is known to enhance normal platelet biosynthesis of pro‐aggregating thromboxane A2, we tested whether or not the reported increased sensitivity of diabetic platelets to ADP may also result in increased platelet biosynthesis of thromboxane A2. To test this hypothesis, 14C‐... hiện toàn bộ
Increased production of platelet thromboxane B2 in non‐insulin‐dependent diabetes. Relationship to vascular complications
European Journal of Clinical Investigation - Tập 14 Số 2 - Trang 83-86 - 1984
Armando D’Angelo, P. Micossi, Pier Mannuccio Mannucci, Barbara Garimberti, Franca Franchi, G. Pozza
Abstract. Platelet thromboxane B2 production was studied in forty‐seven non‐insulin‐dependent diabetics by incubating platelets with increasing concentrations of arachidonic acid. In comparison with thirty‐two healthy subjects, diabetics showed increased thromboxane B2 production at 0·7 mmol/l (mean: 236 pmol/108 platelets, SEM 201–277; v. 135, 105–174; P < 0·05) and at 1·0 mmol/l (673, 613–739; v... hiện toàn bộ
Post‐prandial lipoprotein metabolism in nephrotic syndrome
European Journal of Clinical Investigation - Tập 22 Số 12 - Trang 813-820 - 1992
Graham Warwick, C.J. Packard, Jennifer Stewart, T. D. G. Watson, L. Burns, J. M. Boulton‐Jones, J. Shepherd
Abstract.Post‐prandial lipaemia was investigated in a group of nine subjects with nephrotic syndrome by following the concentrations of triglyceride and retinyl palmitate in the d< 1.006 g ml‐1fraction of plasma after a standard oral fat load containing vitamin A. Lipoprotein lipase and hepatic triglyceride lipase activities were measured in post‐heparin plasma. Subjects with other renal disease b... hiện toàn bộ
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