The Effect of Spironolactone on Transport of Na<sup>+</sup>., K<sup>+</sup> and H<sup>+</sup>. A Microperfusion Study in Rat Main Submaxillary Duct*

European Journal of Clinical Investigation - Tập 6 Số 1 - Trang 17-20 - 1976
H. Knauf1, K. Pander1, Stéphane Franck1
1Department of Internal Medicine, University of Freiburg i. Br., Germany

Tóm tắt

The epithelium of the main excretory duct of the rat submaxillary gland was used as a target tissue for studies on the effect of a spironolactone on electrolyte transport. The spironolactone decreased net Na+ reabsorption by 27 % and net K+ secretion by 23 %. HCO3 was found to be about 2‐fold accumulated in the duct lumen, which was considered to result from decreased H+ion secretion. The results can be reconciled with an action of spironolactone on 1) the peritubular Na+‐K+‐exchange mechanism and 2) the functional coupling of Na+ entry from lumen to cell with K+ and H+ transfer from cell to lumen.

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European Journal of Clinical Investigation

Tập 6 Số 1

17-20

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