European Journal of Clinical Investigation
SCIE-ISI SCOPUS (1970-2025)
0014-2972
1365-2362
Anh Quốc
Cơ quản chủ quản: WILEY , Wiley-Blackwell Publishing Ltd
Lĩnh vực:
BiochemistryClinical BiochemistryMedicine (miscellaneous)
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction
Tập 32 Số s3 - Trang 14-23 - 2002
AbstractPlasma free fatty acids (FFA) play important physiological roles in
skeletal muscle, heart, liver and pancreas. However, chronically elevated plasma
FFA appear to have pathophysiological consequences. Elevated FFA concentrations
are linked with the onset of peripheral and hepatic insulin resistance and,
while the precise action in the liver remains unclear, a model to explain the
role of r...
Glucagon‐like peptide‐1 cells in the gastrointestinal tract and pancreas of rat, pig and man
Tập 22 Số 4 - Trang 283-291 - 1992
Abstract. A highly specific monoclonal antibody directed against the C‐terminal
part of glucagon‐like peptide‐1 (GLP‐1) was raised to immunohistochemi‐cally
evaluate the distribution of GLP‐1 containing cells in the entire
gastrointestinal tract including pancreas of rat, pig and man. In the pancreas
GLP‐1 ‐immunoreactive cells were found variously shaped and predominantly
located in the periphery...
Anti‐inflammatory effects of exercise: role in diabetes and cardiovascular disease
Tập 47 Số 8 - Trang 600-611 - 2017
AbstractBackgroundPersistent inflammation is involved in the pathogenesis of
chronic diseases such as type 2 diabetes mellitus (T2DM) and cardiovascular
disease (CVD).AimsThe aim of this review was to provide the reader with an
update of the mechanisms whereby exercise‐induced cytokines may impact
cardiometabolic diseases.ResultsEvidence exists that interleukin (IL)‐1β is
involved in pancreatic β‐...
Radioimmunoassay for type III procollagen peptide and its application to human liver disease
Tập 9 Số 6 - Trang 451-459 - 1979
Abstract. A sensitive and specific radioimmunoassay was developed for the
precursor‐specific peptide segment located at the amino end of bovine type III
procollagen. Human material showed high cross‐reactivity in this assay. Two
forms of human procollagen peptides were detected in body fluids. The larger
peptide (45K) was found in serum and ascites, and resembled the whole
precursor‐specific segme...
Encapsulated fish oil enriched in α‐tocopherol alters plasma phospholipid and mononuclear cell fatty acid compositions but not mononuclear cell functions
Tập 30 Số 3 - Trang 260-274 - 2000
BackgroundSeveral studies have reported that dietary fish oil (FO)
supplementation alters cytokine production and other functional activities of
peripheral blood mononuclear cells (PBMC). However, few of these studies have
been placebo controlled and few have related the functional changes to
alterations in PBMC fatty acid compositionPatients and methodsHealthy subjects
supplemented their diets wi...
Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin
Tập 33 Số 7 - Trang 536-542 - 2003
AbstractBackground To investigate whether microvascular function in skin is a
valid model to study the relationships between cardiovascular risk factors and
microvascular function, we investigated skin microvascular function in
individuals with increased coronary heart disease (CHD) risk.Materials and
methods Forty‐six healthy White individuals aged 30–70 years were studied.
Coronary heart disease...
The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications
Tập 45 Số 6 - Trang 609-623 - 2015
AbstractBackgroundHepatocellular carcinoma (HCC) is still a major health
problem, often diagnosed at an advanced stage. The multikinase inhibitor
sorafenib is to date the sole approved systemic therapy. Several signalling
pathways are implicated in tumour development and progression. Among these
pathways, the Ras/MAPK pathway is activated in 50–100% of human HCCs and is
correlated with a poor prog...
STrengthening the REporting of Genetic Association studies (STREGA) – an extension of the STROBE statement
Tập 39 Số 4 - Trang 247-266 - 2009
AbstractMaking sense of rapidly evolving evidence on genetic associations is
crucial to making genuine advances in human genomics and the eventual
integration of this information in the practice of medicine and public health.
Assessment of the strengths and weaknesses of this evidence, and hence the
ability to synthesize it, has been limited by inadequate reporting of results.
The STrengthening th...
Localization of collagen mRNA in normal and scleroderma skin by in‐situ hybridization
Tập 18 Số 1 - Trang 9-17 - 1988
Abstract. Scleroderma is a fibrotic disease occurring in a localized or systemic
form. Disturbed regulation of connective tissue metabolism plays an important
role in its pathogenesis. However, until now, most of the data available were
obtained from studies of fibroblasts in culture and there is considerable doubt
that fibroblasts in a monolayer reflect the in‐vivo situation. Using in‐situ
hybrid...
Sulphur containing amino acids in chronic renal failure with particular reference to homocystine and cysteine‐homocysteine mixed disulphide
Tập 9 Số 4 - Trang 301-307 - 1979
Abstract. We measured plasma sulphur amino acids in twenty‐two patients with
chronic renal failure and compared the findings with those obtained in
twenty‐two normal subjects. In fasting blood (08.00 hours) cysteine‐homocysteine
mixed disulphide was significantly increased in the renal patients, mean values
(± SD) being 8.2 ± 3.4 and 3.1 ± 1.0 μmol/l respectively (P < 0.001). The
increase was posi...