European Journal of Clinical Investigation
SCIE-ISI SCOPUS (1970-2023)
0014-2972
1365-2362
Anh Quốc
Cơ quản chủ quản: WILEY , Wiley-Blackwell Publishing Ltd
Lĩnh vực:
BiochemistryClinical BiochemistryMedicine (miscellaneous)
Các bài báo tiêu biểu
Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunctionAbstract Plasma free fatty acids (FFA) play important physiological roles in skeletal muscle, heart, liver and pancreas. However, chronically elevated plasma FFA appear to have pathophysiological consequences. Elevated FFA concentrations are linked with the onset of peripheral and hepatic insulin resistance and, while the precise action in the liver remains unclear,... ...
Tập 32 Số s3 - Trang 14-23 - 2002
Glucagon‐like peptide‐1 cells in the gastrointestinal tract and pancreas of rat, pig and manAbstract. A highly specific monoclonal antibody directed against the C‐terminal part of glucagon‐like peptide‐1 (GLP‐1) was raised to immunohistochemi‐cally evaluate the distribution of GLP‐1 containing cells in the entire gastrointestinal tract including pancreas of rat, pig and man. In the pancreas GLP‐1 ‐immunoreactive cells were found variously shaped and predom...
Tập 22 Số 4 - Trang 283-291 - 1992
Anti‐inflammatory effects of exercise: role in diabetes and cardiovascular diseaseAbstract Background Persistent inflammation is involved in the pathogenesis of chronic diseases such as type 2 diabetes mellitus (T2DM ) and cardiovascular disease (CVD ). ...
Tập 47 Số 8 - Trang 600-611 - 2017
Radioimmunoassay for type III procollagen peptide and its application to human liver diseaseAbstract. A sensitive and specific radioimmunoassay was developed for the precursor‐specific peptide segment located at the amino end of bovine type III procollagen. Human material showed high cross‐reactivity in this assay. Two forms of human procollagen peptides were detected in body fluids. The larger peptide (45K) was found in serum and ascites, and resembled th...
Tập 9 Số 6 - Trang 451-459 - 1979
Encapsulated fish oil enriched in α‐tocopherol alters plasma phospholipid and mononuclear cell fatty acid compositions but not mononuclear cell functionsBackground Several studies have reported that dietary fish oil (FO) supplementation alters cytokine production and other functional activities of peripheral blood mononuclear cells (PBMC). However, few of these studies have been placebo controlled and few have related the functional changes to alterations in PBMC fatty acid composition
Tập 30 Số 3 - Trang 260-274 - 2000
Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skinAbstract Background To investigate whether microvascular function in skin is a valid model to study the relationships between cardiovascular risk factors and microvascular function, we investigated skin microvascular function in individuals with increased coronary heart disease (CHD) risk.Materials and methods...
Tập 33 Số 7 - Trang 536-542 - 2003
The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implicationsAbstract Background Hepatocellular carcinoma (HCC ) is still a major health problem, often diagnosed at an advanced stage. The multikinase inhibitor sorafenib is to date the sole approved systemic therapy. Several signalling pathways are implicated in tumour development an...
Tập 45 Số 6 - Trang 609-623 - 2015
STrengthening the REporting of Genetic Association studies (STREGA) – an extension of the STROBE statementAbstract Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting... ...
Tập 39 Số 4 - Trang 247-266 - 2009
Localization of collagen mRNA in normal and scleroderma skin by in‐situ hybridizationAbstract. Scleroderma is a fibrotic disease occurring in a localized or systemic form. Disturbed regulation of connective tissue metabolism plays an important role in its pathogenesis. However, until now, most of the data available were obtained from studies of fibroblasts in culture and there is considerable doubt that fibroblasts in a monolayer reflect the ...
Tập 18 Số 1 - Trang 9-17 - 1988
Sulphur containing amino acids in chronic renal failure with particular reference to homocystine and cysteine‐homocysteine mixed disulphideAbstract. We measured plasma sulphur amino acids in twenty‐two patients with chronic renal failure and compared the findings with those obtained in twenty‐two normal subjects. In fasting blood (08.00 hours) cysteine‐homocysteine mixed disulphide was significantly increased in the renal patients, mean values (± SD) being 8.2 ± 3.4 and 3.1 ± 1.0 μmol/l respectively (<...
Tập 9 Số 4 - Trang 301-307 - 1979