Increased production of platelet thromboxane B2 in non‐insulin‐dependent diabetes. Relationship to vascular complications

European Journal of Clinical Investigation - Tập 14 Số 2 - Trang 83-86 - 1984
Armando D’Angelo1, P. Micossi2, Pier Mannuccio Mannucci1, Barbara Garimberti2, Franca Franchi1, G. Pozza2
1Clinica Medica III and Haemophilia and Thrombosis Centre A Bianchi Bonomi, Università degli Studi di Milano, Italy
2Clinica Medica VIII, Università degli Studi di Milano, Italy

Tóm tắt

Abstract. Platelet thromboxane B2 production was studied in forty‐seven non‐insulin‐dependent diabetics by incubating platelets with increasing concentrations of arachidonic acid. In comparison with thirty‐two healthy subjects, diabetics showed increased thromboxane B2 production at 0·7 mmol/l (mean: 236 pmol/108 platelets, SEM 201–277; v. 135, 105–174; P < 0·05) and at 1·0 mmol/l (673, 613–739; v. 405, 377–486, P < 0·01) but not at 0·5 mmol/l. Patients were subdivided according to the presence or absence of vascular complications. Patients without microangiopathy showed significantly greater thromboxane B2 production than healthy subjects at all the arachidonic‐acid concentrations (P < 0·02 or less). Patients with microangiopathy had platelet thromboxane production similar to that observed in healthy subjects at all the arachidonic‐acid concentrations (P > 0·30) but significantly lower than that of non‐microangiopathic patients at 0·5 (P < 0·01) and at 0·7 mmol/l arachidonic acid (P < 0·05). These results indicate that non‐insulin‐dependent diabetics have increased production of platelet thromboxane B2 only when they do not have microvascular complications.

Từ khóa


Tài liệu tham khảo

Keen II, 1975, Complications of diabetes, 1

10.1056/NEJM198002143020710

10.2337/diab.29.11.931

10.1111/j.1365-2141.1980.tb08705.x

10.2337/diab.27.3.342

10.1056/NEJM197712152972408

10.1111/j.1365-2362.1979.tb00927.x

10.1016/0049-3848(80)90420-X

Halushka PV, 1981, Increased platelet thromboxane synthesis in diabetes mellitus, J Lab Clin Med, 97, 87

10.1016/0161-4630(79)90059-4

10.1056/NEJM197102182840703

10.1016/0009-8981(62)90062-1

10.1007/BF01747717

Johnson M., 1979, Platelet abnormalities in experimental diabetes, Thromb Haemostas, 42, 333

Gerrard JM, 1980, Alterations in the balance of prostaglandin and thromboxane synthesis in diabetes, J Lab Clin Med, 95, 950

10.1136/bmj.283.6300.1148

Weiss HJ., 1982, Platelets pathophysiology and antiplatelet drug therapy, 45

10.1073/pnas.76.1.121

10.1097/00007890-198203000-00017

Thông tin
Thông tin xuất bản

European Journal of Clinical Investigation

Tập 14 Số 2

83-86

Thông tin tác giả