State of the art in selection of variables and functional forms in multivariable analysis—outstanding issues Tập 4 Số 1 - 2020
Willi Sauerbrei, Aris Perperoglou, Matthias Schmid, Michal Abrahamowicz, Heiko Becher, Harald Binder, Daniela Dunkler, Frank E. Harrell, Patrick Royston, Georg Heinze
AbstractBackgroundHow to select variables and identify functional forms for continuous variables is a key concern when creating a multivariable model. Ad hoc ‘traditional’ approaches to variable selection have been in use for at least 50 years. Similarly, methods for determining functional forms for continuous variables were first...... hiện toàn bộ
Continual updating and monitoring of clinical prediction models: time for dynamic prediction systems? Tập 5 Số 1 - 2021
David Jenkins, Glen P. Martin, Matthew Sperrin, Richard D Riley, Thomas P A Debray, Gary S. Collins, Niels Peek
AbstractClinical prediction models (CPMs) have become fundamental for risk stratification across healthcare. The CPM pipeline (development, validation, deployment, and impact assessment) is commonly viewed as a one-time activity, with model updating rarely considered and done in a somewhat ad hoc manner. This fails to address the fact that the performance of a CPM ...... hiện toàn bộ
A generic nomogram for multinomial prediction models: theory and guidance for construction Tập 1 - Trang 1-7 - 2017
Maarten van Smeden, Joris AH de Groot, Stavros Nikolakopoulos, Loes CM Bertens, Karel GM Moons, Johannes B. Reitsma
The use of multinomial logistic regression models is advocated for modeling the associations of covariates with three or more mutually exclusive outcome categories. As compared to a binary logistic regression analysis, the simultaneous modeling of multiple outcome categories using a multinomial model often better resembles the clinical setting, where a physician typically must distinguish between ...... hiện toàn bộ
Predictors of the effects of treatment for shoulder pain: protocol of an individual participant data meta-analysis Tập 3 Số 1 - 2019
D.A.W.M. van der Windt, Danielle L. Burke, Opeyemi Babatunde, Miriam Hattle, Cliona McRobert, Chris Littlewood, Gwenllian Wynne‐Jones, Linda S Chesterton, Geert J. M. G. van der Heijden, Jan C. Winters, Daniel I. Rhon, Kim L Bennell, Edward Roddy, Carl Heneghan, David Beard, Jonathan Rees, Richard D Riley
Development of a clinical prediction rule for sepsis in primary care: protocol for the TeSD-IT study Tập 4 - Trang 1-9 - 2020
Feike J. Loots, Rogier Hopstaken, Kevin Jenniskens, Geert W. J. Frederix, Alma C. van de Pol, Ann Van den Bruel, Jan Jelrik Oosterheert, Arthur R. H. van Zanten, Marleen Smits, Theo J. M. Verheij
Early recognition and treatment of sepsis is crucial to prevent detrimental outcomes. General practitioners (GPs) are often the first healthcare providers to encounter seriously ill patients. The aim of this study is to assess the value of clinical information and additional tests to develop a clinical prediction rule to support early diagnosis and management of sepsis by GPs. We will perform a di...... hiện toàn bộ