DMM Disease Models and Mechanisms
SCOPUS (2008-2023)SCIE-ISI
1754-8403
1754-8411
Anh Quốc
Cơ quản chủ quản: COMPANY BIOLOGISTS LTD , Company of Biologists Ltd
Lĩnh vực:
Medicine (miscellaneous)Biochemistry, Genetics and Molecular Biology (miscellaneous)Neuroscience (miscellaneous)Immunology and Microbiology (miscellaneous)
Các bài báo tiêu biểu
A comprehensive definition for metabolic syndromeThe metabolic syndrome refers to the co-occurrence of several known cardiovascular risk factors, including insulin resistance, obesity, atherogenic dyslipidemia and hypertension. These conditions are interrelated and share underlying mediators, mechanisms and pathways. There has been recent controversy about its definition and its utility. In this article, I review the current definitions ... ...
Tập 2 Số 5-6 - Trang 231-237 - 2009
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancerDynamic remodeling of the extracellular matrix (ECM) is essential for development, wound healing and normal organ homeostasis. Life-threatening pathological conditions arise when ECM remodeling becomes excessive or uncontrolled. In this Perspective, we focus on how ECM remodeling contributes to fibrotic diseases and cancer, which both present challenging obstacles with respect to clinical ... ...
Tập 4 Số 2 - Trang 165-178 - 2011
Cellular and molecular mechanisms of muscle atrophySkeletal muscle is a plastic organ that is maintained by multiple pathways regulating cell and protein turnover. During muscle atrophy, proteolytic systems are activated, and contractile proteins and organelles are removed, resulting in the shrinkage of muscle fibers. Excessive loss of muscle mass is associated with poor prognosis in several diseases, including myopathies and muscular dyst... ...
Tập 6 Số 1 - Trang 25-39 - 2013
Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour developmentAn increased rate of lipid synthesis in cancerous tissues has long been recognised as an important aspect of the rewired metabolism of transformed cells. However, the contribution of lipids to cellular transformation, tumour development and tumour progression, as well as their potential role in facilitating the spread of cancerous cells to secondary sites, are not yet fully understood. In ... ...
Tập 6 Số 6 - Trang 1353-1363 - 2013
Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesityABSTRACT
The ‘obesity epidemic’ represents a major global socioeconomic burden that urgently calls for a better understanding of the underlying causes of increased weight gain and its associated metabolic comorbidities, such as type 2 diabetes mellitus and cardiovascular diseases. Improving our understanding of the cellular basis of obesity could set... ...
Tập 10 Số 6 - Trang 679-689 - 2017
Diverse functions of matrix metalloproteinases during fibrosisABSTRACT Fibrosis – a debilitating condition that can occur in most organs – is characterized by excess deposition of a collagen-rich extracellular matrix (ECM). At first sight, the activities of proteinases that can degrade matrix, such as matrix metalloproteinases (MMPs), might be expected to be under-expressed in fibrosis or, if present, could function to resolve... ...
Tập 7 Số 2 - Trang 193-203 - 2014
Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases Summary Dysregulation of cholesterol homeostasis in the brain is increasingly being linked to chronic neurodegenerative disorders, including Alzheimer’s disease (AD), Huntington’s disease (HD), Parkinson’s disease (PD), Niemann-Pick type C (NPC) disease and Smith-Lemli Opitz syndrome (SLOS). However, the molecular mechanisms underlying the correlation between altere... ...
Neuronal regeneration in a zebrafish model of adult brain injurySUMMARY Neural stem cells in the subventricular zone (SVZ) of the adult mammalian forebrain are a potential source of neurons for neural tissue repair after brain insults such as ischemic stroke and traumatic brain injury (TBI). Recent studies show that neurogenesis in the ventricular zone (VZ) of the adult zebrafish telencephalon has features in common with neuroge... ...
Tập 5 Số 2 - Trang 200-209 - 2012
Molecular biomarkers of Alzheimer's disease: progress and prospectsABSTRACT
The neurodegenerative disorder Alzheimer's disease is characterised by the formation of β-amyloid plaques and neurofibrillary tangles in the brain parenchyma, which cause synapse and neuronal loss. This leads to clinical symptoms, such as progressive memory deficits. Clinically, these pathological changes can be detected in the cerebrospinal... ...
Tập 11 Số 5 - 2018
Leading the way: canine models of genomics and diseaseIn recent years Canis familiaris, the domestic dog, has drawn considerable attention as a system in which to investigate the genetics of disease susceptibility, morphology and behavior. Because dogs show remarkable intrabreed homogeneity, coupled with striking interbreed heterogeneity, the dog offers unique opportunities to understand the genetic underpinnings of natural variation in mamma... ...
Tập 3 Số 1-2 - Trang 27-34 - 2010