DMM Disease Models and Mechanisms

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The role of gamma interferon in innate immunity in the zebrafish embryo
DMM Disease Models and Mechanisms - Tập 2 Số 11-12 - Trang 571-581 - 2009
Dirk Sieger, Cornelia Stein, David Neifer, Astrid M. van der Sar, Maria Leptin
SUMMARYThe zebrafish genome contains ten genes that encode class II cytokine-like peptides, of which the two that are related most closely to mammalian interferon gamma (IFN-γ) were named IFN-γ1 and IFN-γ2. Although the zebrafish has become a popular model system to study immune mechanisms, and although interferons are central regulators of immunity, which zebrafish cytokines correspond functional... hiện toàn bộ
Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development
DMM Disease Models and Mechanisms - Tập 6 Số 6 - Trang 1353-1363 - 2013
Franziska Baenke, Barrie Peck, Heike Miess, Almut Schulze
An increased rate of lipid synthesis in cancerous tissues has long been recognised as an important aspect of the rewired metabolism of transformed cells. However, the contribution of lipids to cellular transformation, tumour development and tumour progression, as well as their potential role in facilitating the spread of cancerous cells to secondary sites, are not yet fully understood. In this art... hiện toàn bộ
A comprehensive definition for metabolic syndrome
DMM Disease Models and Mechanisms - Tập 2 Số 5-6 - Trang 231-237 - 2009
Paul L. Huang
The metabolic syndrome refers to the co-occurrence of several known cardiovascular risk factors, including insulin resistance, obesity, atherogenic dyslipidemia and hypertension. These conditions are interrelated and share underlying mediators, mechanisms and pathways. There has been recent controversy about its definition and its utility. In this article, I review the current definitions for the ... hiện toàn bộ
Combinatorial effect of maytansinol and radiation inDrosophilaand human cancer cells
DMM Disease Models and Mechanisms - Tập 4 Số 4 - Trang 496-503 - 2011
Anthony Edwards, Mara Gladstone, Petros Yoon, David Raben, Barbara Frederick, Tin Tin Su
SUMMARYCombination therapy, in which two or more agents are applied, is more effective than single therapies for combating cancer. For this reason, combinations of chemotherapy with radiation are being explored in clinical trials, albeit with an empirical approach. We developed a screen to identify, from the onset, molecules that act in vivo in conjunction with radiation, using Drosophila as a mod... hiện toàn bộ
Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation
DMM Disease Models and Mechanisms - Tập 3 Số 3-4 - Trang 224-235 - 2010
Nathalie Ortéga, Ke Wang, Napoleone Ferrara, Zena Werb, Thiennu H. Vu
SUMMARYLong bone development depends on endochondral bone formation, a complex process requiring exquisite balance between hypertrophic cartilage (HC) formation and its ossification. Dysregulation of this process may result in skeletal dysplasias and heterotopic ossification. Endochondral ossification requires the precise orchestration of HC vascularization, extracellular matrix remodeling, and th... hiện toàn bộ
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
DMM Disease Models and Mechanisms - Tập 4 Số 2 - Trang 165-178 - 2011
Thomas R. Cox, Janine T. Erler
Dynamic remodeling of the extracellular matrix (ECM) is essential for development, wound healing and normal organ homeostasis. Life-threatening pathological conditions arise when ECM remodeling becomes excessive or uncontrolled. In this Perspective, we focus on how ECM remodeling contributes to fibrotic diseases and cancer, which both present challenging obstacles with respect to clinical treatmen... hiện toàn bộ
Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases
DMM Disease Models and Mechanisms -
Jean E. Vance
SummaryDysregulation of cholesterol homeostasis in the brain is increasingly being linked to chronic neurodegenerative disorders, including Alzheimer’s disease (AD), Huntington’s disease (HD), Parkinson’s disease (PD), Niemann-Pick type C (NPC) disease and Smith-Lemli Opitz syndrome (SLOS). However, the molecular mechanisms underlying the correlation between altered cholesterol metabolism and the ... hiện toàn bộ
Cryptosporidium parvum-induced ileo-caecal adenocarcinoma and WNT signaling in a rodent model
DMM Disease Models and Mechanisms -
Sadia Benamrouz-Vanneste, Valérie Conseil, Magali Chabé, Marleen Praet, Christophe Audebert, Renaud Blervaque, Karine Guyot, Sophie Gazzola, Anthony Mouray, Thierry Chassat, Baptiste Delaire, Nathalie Goetinck, Nausicaa Gantois, Marwan Osman, Natalia Prevarskaya, Vanessa Dehennaut, Tony Lefebvre, Éric Viscogliosi, Claude Cuvelier, Sergio L. Vargas, Colette Creusy, Gabriela Certad
Abstract Cryptosporidium species are worldwide spread apicomplexan protozoan. These parasites constitute a significant risk to humans and animals. They cause self-limited diarrhea in immunocompetent hosts and a life threatening disease in immunocompromised hosts. Interestingly, Cryptosporidium parvum has been related to digestive carcinogenesis in humans. Consistently with a potential tumorigenic ... hiện toàn bộ
MicroRNA screening identifies a link between NOVA1 expression and low level of IKAP/ELP1 in Familial dysautonomia
DMM Disease Models and Mechanisms - - 2016
Mylène Hervé, El Chérif Ibrahim
Familial dysautonomia (FD) is a rare neurodegenerative disease caused by a mutation in intron 20 of the IKBKAP gene (c.2204+6T>C), leading to tissue-specific skipping of exon 20 and decrease of IKAP/hELP1 synthesis. Small non-coding RNAs, microRNAs (miRNAs) are important posttranscriptional regulators of gene expression and play an essential role in the nervous system development and function. ... hiện toàn bộ
Molecular biomarkers of Alzheimer's disease: progress and prospects
DMM Disease Models and Mechanisms - Tập 11 Số 5 - 2018
Tammaryn Lashley, Jonathan M. Schott, Philip S.J. Weston, Christina E. Murray, Henny Wellington, Ashvini Keshavan, Sandrine C. Foti, Martha Foiani, Jamie Toombs, Jonathan D. Rohrer, Amanda Heslegrave, Henrik Zetterberg
ABSTRACT The neurodegenerative disorder Alzheimer's disease is characterised by the formation of β-amyloid plaques and neurofibrillary tangles in the brain parenchyma, which cause synapse and neuronal loss. This leads to clinical symptoms, such as progressive memory deficits. Clinically, these pathological changes can be detected in the cerebrospinal fluid and with brain imaging, although reliable... hiện toàn bộ
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