DARU Journal of Pharmaceutical Sciences
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Protective and therapeutic effects of Scutellaria baicalensis and its main active ingredients baicalin and baicalein against natural toxicities and physical hazards: a review of mechanisms
DARU Journal of Pharmaceutical Sciences - Tập 30 - Trang 351-366 - 2022
Scutellaria baicalensis (SB) has been traditionally used to combat a variety of conditions ranging from ischemic heart disease to cancer. The protective effects of SB are due to the action of two main flavonoids baicalin (BA) and baicalein (BE). This paper aimed to provide a narrative review of the protective and antidotal effects of SB and its main constituents against natural toxicities and phys...... hiện toàn bộ
Isotretinoin-associated Sweet’s syndrome: a case report
DARU Journal of Pharmaceutical Sciences - Tập 22 - Trang 1-4 - 2014
Sweet’s syndrome (SS) is characterized by various clinical symptoms, physical features, and pathological findings. Although cases of SS are very rare, there has been an increase in the incidence of drug-induced SS. Till date, there have been only few reported cases of isotretinoin-induced SS. In this report, we describe the case of a 19-year-old girl who developed SS after systemic treatment with ...... hiện toàn bộ
Improved activity and expression of recombinant human factor IX by propeptide engineering
DARU Journal of Pharmaceutical Sciences - Tập 27 - Trang 653-660 - 2019
The main therapeutic strategy for Hemophilia B patients involves the administration of recombinant coagulation factors IX (rFIX). Although there are various approaches to increasing the activity of rFIX, targeted protein engineering of specific residues could result in increased rFIX activity through enhanced γ-carboxylation. Specific amino acids in the propeptide sequence of vitamin K-dependent p...... hiện toàn bộ
Development of a validated UPLC-qTOF-MS Method for the determination of curcuminoids and their pharmacokinetic study in mice
DARU Journal of Pharmaceutical Sciences - Tập 21 - Trang 1-10 - 2013
A specific and sensitive UPLC-qTOF-MS/MS method has been developed for the simultaneous determination of curcuminoids. These Curcuminoids comprises of curcumin, a principal curcuminoid and other two namely, demethoxycurcumin, and bisdemethoxycurcumin obtained from rhizomes of Curcuma longa an ancient Indian curry spice turmeric, family (Zingiberaceae). These analytes were separated on a reverse ph...... hiện toàn bộ
Simultaneous detection of bovine and porcine DNA in pharmaceutical gelatin capsules by duplex PCR assay for Halal authentication
DARU Journal of Pharmaceutical Sciences - Tập 25 - Trang 1-11 - 2017
In the pharmaceutical industry, hard- and soft-shelled capsules are typically made from gelatin, commonly derived from bovine and porcine sources. To ensure that pharmaceutical products comply with halal regulations in Muslim countries (no porcine products allowed), development of a valid, reliable, quick, and most importantly, cost-effective tests are of utmost importance. We developed a species-...... hiện toàn bộ
Paclitaxel incorporated exosomes derived from glioblastoma cells: comparative study of two loading techniques
DARU Journal of Pharmaceutical Sciences - Tập 27 - Trang 533-539 - 2019
Exosomes are natural nanoparticles that are involved in intercellular communication via transferring molecular information between cells. Recently, exosomes have been considered for exploitation as novel drug delivery systems due to their specific properties for carrying specific molecules and surface proteins. In this study, U-87 cell derived exosomes have been investigated for delivery of a pote...... hiện toàn bộ
The analgesic potential of glycosides derived from medicinal plants
DARU Journal of Pharmaceutical Sciences - - 2020
In vitro investigation of the effects of boron nitride nanotubes and curcumin on DNA damage
DARU Journal of Pharmaceutical Sciences - Tập 27 - Trang 203-218 - 2019
Stem cells provide an opportunity to analyse the effects of xenobiotic on cell viability, differentiation and cell functions. Evaluation of the possible cytotoxic and DNA damaging effects on bone marrow CD34+ stem cells is important for their ability to differentiate into blood cells, and also for bone marrow diseases therapy. Boron nitride nanotubes and curcumin are potential nanoformulation agen...... hiện toàn bộ
Design, synthesis, and biological evaluation of polyphenols with 4,6-diphenylpyrimidin-2-amine derivatives for inhibition of Aurora kinase A
DARU Journal of Pharmaceutical Sciences - Tập 27 Số 1 - Trang 265-281 - 2019
Hydroxylation index of omeprazole in relation to CYP2C19 polymorphism and sex in a healthy Iranian population
DARU Journal of Pharmaceutical Sciences - Tập 22 - Trang 1-9 - 2014
Polymorphism of CYP2C19 gene is one of the important factors in pharmacokinetics of CYP2C19 substrates. Omeprazole is a proton pump inhibitor which is mainly metabolized by cytochrome P450 2C19 (CYP2C19). The aim of present study was to assess omeprazole hydroxylation index as a measure of CYP2C19 activity considering new variant allele (CYP2C19*17) in Iranian population and also to see if this ac...... hiện toàn bộ
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