Current Oncology
SCOPUS (1998-2025)SCIE-ISI
1718-7729
1198-0052
Canada
Cơ quản chủ quản: MDPI , Multidisciplinary Digital Publishing Institute (MDPI)
Lĩnh vực:
Oncology
Các bài báo tiêu biểu
A Review of Cancer Immunotherapy: From the Past, to the Present, to the Future
Tập 27 Số 12 - Trang 87-97
Compared with previous standards of care (including chemotherapy, radiotherapy,
and surgery), cancer immunotherapy has brought significant improvements for
patients in terms of survival and quality of life. Immunotherapy has now firmly
established itself as a novel pillar of cancer care, from the metastatic stage
to the adjuvant and neoadjuvant settings in numerous cancer types. In this
review art...
Immune Checkpoint Inhibitors in Cancer Therapy
Tập 29 Số 5 - Trang 3044-3060
The discovery of immune checkpoint proteins such as PD-1/PDL-1 and CTLA-4
represents a significant breakthrough in the field of cancer immunotherapy.
Therefore, humanized monoclonal antibodies, targeting these immune checkpoint
proteins have been utilized successfully in patients with metastatic melanoma,
renal cell carcinoma, head and neck cancers and non-small lung cancer. The US
FDA has success...
Nonsurgical Treatment of Recurrent Glioblastoma
Tập 22 Số 4 - Trang 273-281
Standard treatment for glioblastoma multiforme is surgery followed by
radiotherapy and chemotherapy, generally with temozolomide. However, disease
recurs in almost all patients. Diagnosis of progression is complex given the
possibility of pseudoprogression. The Response Assessment in Neuro-Oncology
criteria increase the sensitivity for detecting progression. Most patients will
not be candidates fo...
Survival of Patients with Non-Small-Cell Lung Cancer after a Diagnosis of Brain Metastases
Tập 20 Số 4 - Trang 300-306
Background: The prognosis of patients with brain metastases from non-small-cell
lung cancer (NSCLC) is poor. However, some reports suggest that patients with
brain metastases at the time of initial diagnosis have a more favourable
survival than do patients with advanced NSCLC without brain metastases. Methods:
In a retrospective cohort of all new lung cancer patients seen at a Canadian
tertiary ce...
Treatment Paradigms for Patients with Metastatic Non-Small-Cell Lung Cancer: First-, Second-, and Third-Line
Tập 19 Số 11 - Trang 52-58
Metastatic non-small-cell lung cancer (NSCLC) is the leading cause of cancer
mortality in Canada. Although treatment outcomes in advanced disease remain
modest, with paradigm shifts in the approach to treatment, they are steadily
improving. Customizing treatment based on histology and molecular typing has
become the standard of care. EGFR genotyping and pathology subtyping should be
considered rou...
Multidisciplinary Management of Cancer Patients: Chasing a Shadow or Real Value? An Overview of the Literature
Tập 19 Số 4 - Trang 232-238
Purpose: Multidisciplinary cancer conferences (mccs) are designed to optimize
patient outcomes. It appears intuitive that mccs are essential to clinical
decision-making and patient management; however, it is unclear whether that
belief is supported by evidence. Our objectives were to assess the currently
published literature addressing the impact of mccs on clinical decision-making
and patient out...
Cancer and Venous Thromboembolic Disease: From Molecular Mechanisms to Clinical Management
Tập 21 Số 3 - Trang 134-143
Venous thromboembolism (VTE) represents a major challenge in the management of
patients with cancer. The malignant phenotype is associated with derangements in
the coagulation cascade that can manifest as thrombosis, hemorrhage, or
disseminated intravascular coagulation. The risk of VTE is increased by a factor
of approximately 6 in patients with cancer compared with non-cancer patients,
and cance...
A Systematic Review of Acupuncture for Chemotherapy-Induced Peripheral Neuropathy
Tập 26 Số 2 - Trang 4261
Objectives: In cancer patients, chemotherapy-induced peripheral neuropathy
(cipn) is a common complication, characterized by pain, loss of sensation, and
numbness. Medical treatment for peripheral neuropathies has been shown to be
ineffective for cipn. Acupuncture has been shown to be safe and effective in
treating cancer-related symptoms and other peripheral neuropathies. For the
present review, ...
ALK Inhibitors, Resistance Development, Clinical Trials
Tập 25 Số 11 - Trang 59-67
The treatment of advanced non-small-cell lung cancer (NSCLC) has undergone a
paradigm shift since the early 2000s. The identification of molecular subtypes
of the disease, based on oncogenic drivers, has led to the development of
personalized medicine and the ability to deliver molecularly targeted therapies
to patients. In the 10 years that have elapsed since the discovery of the ALK
gene in a pa...
Association of Preoperative Anemia and Perioperative Allogenic Red Blood Cell Transfusion with Oncologic Outcomes in Patients with Nonmetastatic Colorectal Cancer
Tập 26 Số 3 - Trang 357-366
Background: We investigated whether preoperative anemia and perioperative blood
transfusion (PBT) are associated with overall survival and recurrence-free
survival in patients with nonmetastatic colorectal cancer. Methods: From 1
January 2009 to 31 December 2014, 1003 patients with primary colorectal cancer
were enrolled in the study. Perioperative clinical and oncologic outcomes were
analyzed bas...