A Review of Cancer Immunotherapy: From the Past, to the Present, to the Future

Current Oncology - Tập 27 Số 12 - Trang 87-97
Khashayar Esfahani1, Liya Roudaia1, Najwa Buhlaiga1, Sonia V. del Rincón2, Neha Papneja1, Wilson H. Miller1
1Departments of Medicine and Oncology, Segal Cancer Centre, Sir Mortimer B. Davis Jewish General Hospital, Rossy Cancer Network, McGill University, Montreal, QC, Canada
2Department of Oncology, Lady Davis Institute, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, QC, Canada

Tóm tắt

Compared with previous standards of care (including chemotherapy, radiotherapy, and surgery), cancer immunotherapy has brought significant improvements for patients in terms of survival and quality of life. Immunotherapy has now firmly established itself as a novel pillar of cancer care, from the metastatic stage to the adjuvant and neoadjuvant settings in numerous cancer types. In this review article, we highlight how the history of cancer immunotherapy paved the way for discoveries that are now part of the standard of care. We also highlight the current pitfalls and limitations of cancer checkpoint immunotherapy and how novel research in the fields of personalized cancer vaccines, autoimmunity, the microbiome, the tumour microenvironment, and metabolomics is aiming to solve those challenges.

Từ khóa


Tài liệu tham khảo

Thông tin
Thông tin xuất bản

Current Oncology

Tập 27 Số 12

87-97

Thông tin tác giả