Current Oncology
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Lazarus-Type Tumour Response to Therapy with Nivolumab for Sarcomatoid Carcinomas of the Lung
Current Oncology - Tập 26 Số 2 - Trang 270-273
Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of non-small-cell lung
carcinoma with a poor prognosis and poor response to chemotherapy and
radiotherapy. A previous study reported that psc expresses high levels of PD-L1,
suggesting the potential efficacy of immune checkpoint inhibitors in these
tumours. We report 2 cases of patients with a lung sarcomatoid carcinoma. Both
patients initial...
Evaluation of a routine screening program with tuberculin skin testing on rates of detection of latent tuberculosis infection and prevention of active tuberculosis in patients with multiple myeloma at a Canadian cancer centre
Current Oncology - Tập 27 Số 3 - Trang e246 - 2020
Lenalidomide in Multiple Myeloma—A Practice Guideline
Current Oncology - Tập 20 Số 2 - Trang 136-149
Background: Promising new drugs such as lenalidomide, an immunomodulatory agent,
are available for the treatment of multiple myeloma. We describe the process of
creating a provincial guideline for the use of lenalidomide, alone or in
combination with other drugs, in relapsed, refractory, or newly diagnosed
disease (including smoldering and symptomatic patients, and candidates and
non-candidates fo...
Association of Preoperative Anemia and Perioperative Allogenic Red Blood Cell Transfusion with Oncologic Outcomes in Patients with Nonmetastatic Colorectal Cancer
Current Oncology - Tập 26 Số 3 - Trang 357-366
Background: We investigated whether preoperative anemia and perioperative blood
transfusion (PBT) are associated with overall survival and recurrence-free
survival in patients with nonmetastatic colorectal cancer. Methods: From 1
January 2009 to 31 December 2014, 1003 patients with primary colorectal cancer
were enrolled in the study. Perioperative clinical and oncologic outcomes were
analyzed bas...
Strategies for the Delay of Surgery in the Management of Resectable Hepatobiliary Malignancies during the COVID-19 Pandemic
Current Oncology - Tập 27 Số 5 - Trang 501-511
Objective: We aimed to review data about delaying strategies for the management
of hepatobiliary cancers requiring surgery during the covid-19 pandemic.
Background: Given the covid-19 pandemic, many jurisdictions, to spare resources,
have limited access to operating rooms for elective surgical activity, including
cancer, thus forcing deferral or cancellation of cancer surgeries. Surgery for
hepato...
Survival of Patients with Non-Small-Cell Lung Cancer after a Diagnosis of Brain Metastases
Current Oncology - Tập 20 Số 4 - Trang 300-306
Background: The prognosis of patients with brain metastases from non-small-cell
lung cancer (NSCLC) is poor. However, some reports suggest that patients with
brain metastases at the time of initial diagnosis have a more favourable
survival than do patients with advanced NSCLC without brain metastases. Methods:
In a retrospective cohort of all new lung cancer patients seen at a Canadian
tertiary ce...
Area-Level Income Disparities in Colorectal Screening in Canada: Evidence to Inform Future Surveillance
Current Oncology - Tập 26 Số 2 - Trang 128-137
Background: Participation in colorectal screening remains low even in countries
with universal health coverage. Area-level determinants of low screening
participation in Canada remain poorly understood. Methods: We assessed the
association between area-level income and two indicators of colorectal screening
(having never been screened, having not been screened recently) by linking
census-derived l...
Recent Trends in Breast, Cervical, and Colorectal Cancer Screening Test Utilization in Canada, Using Self-Reported Data from 2008 and 2012
Current Oncology - Tập 22 Số 4 - Trang 297-302
In Canada, self-reported data from the Canadian Community Health Survey 2008 and
2012 provide an opportunity to examine overall utilization of breast, cervical,
and colorectal cancer screening tests for both programmatic and opportunistic
screening. Among women 50–74 years of age, utilization of screening mammography
was stable (62.0% in 2008 and 63.0% in 2012). Pap test utilization for women
25–6...
Applications of Artificial Intelligence in Screening, Diagnosis, Treatment, and Prognosis of Colorectal Cancer
Current Oncology - Tập 29 Số 3 - Trang 1773-1795
Colorectal cancer (CRC) is one of the most common cancers worldwide. Accurate
early detection and diagnosis, comprehensive assessment of treatment response,
and precise prediction of prognosis are essential to improve the patients’
survival rate. In recent years, due to the explosion of clinical and omics data,
and groundbreaking research in machine learning, artificial intelligence (AI)
has shown...
Treatment Paradigms for Patients with Metastatic Non-Small-Cell Lung Cancer: First-, Second-, and Third-Line
Current Oncology - Tập 19 Số 11 - Trang 52-58
Metastatic non-small-cell lung cancer (NSCLC) is the leading cause of cancer
mortality in Canada. Although treatment outcomes in advanced disease remain
modest, with paradigm shifts in the approach to treatment, they are steadily
improving. Customizing treatment based on histology and molecular typing has
become the standard of care. EGFR genotyping and pathology subtyping should be
considered rou...
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