Clinical and Experimental Immunology
SCOPUS (1966-2023)SCIE-ISI
0009-9104
1365-2249
Anh Quốc
Cơ quản chủ quản: OXFORD UNIV PRESS , Oxford University Press
Lĩnh vực:
Immunology and AllergyImmunology
Các bài báo tiêu biểu
T cells in multiple sclerosis and experimental autoimmune encephalomyelitisSummary Multiple sclerosis (MS) is a demyelinating inflammatory disorder of the central nervous system (CNS), which involves autoimmune responses to myelin antigens. Studies in experimental autoimmune encephalomyelitis (EAE), an animal model for MS, have provided convincing evidence that T cells specific for self-antigens mediate pathology in these diseases. Until r... ... hiện toàn bộ
Tập 162 Số 1 - Trang 1-11 - 2010
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune diseaseSummary Uncommitted (naive) murine CD4+ T helper cells (Thp) can be induced to differentiate towards T helper 1 (Th1), Th2, Th17 and regulatory (Treg) phenotypes according to the local cytokine milieu. This can be demonstrated most readily both in vitro and in vivo in murine CD4+ T cells. The presence of interleukin (IL)-12 [signalling through signal transduction an... ... hiện toàn bộ
Tập 148 Số 1 - Trang 32-46 - 2007
Analysis of islet inflammation in human type 1 diabetesSummary
The immunopathology of type 1 diabetes (T1D) has proved difficult to study in man because of the limited availability of appropriate samples, but we now report a detailed study charting the evolution of insulitis in human T1D. Pancreas samples removed post-mortem from 29 patients (mean age 11·7 years) with recent-onset T1D were analysed by im... ... hiện toàn bộ
Tập 155 Số 2 - Trang 173-181 - 2009
Cell contact, prostaglandin E2 and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25Highforkhead box P3+ regulatory T cellsSummary Adult human mesenchymal stromal or stem cells (MSC) can differentiate into a variety of cell types and are candidate cellular therapeutics in regenerative medicine. Surprisingly, these cells also display multiple potent immunomodulatory capabilities, including allosuppression, making allogeneic cell therapy a possibility. The exact mechanisms involved in reg... ... hiện toàn bộ
Tập 156 Số 1 - Trang 149-160 - 2009
Interferon-γ does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cellsSummary The ability of mesenchymal stem cells (MSC) to suppress alloresponsiveness is poorly understood. Herein, an allogeneic mixed lymphocyte response was used as a model to investigate the mechanisms of MSC-mediated immunomodulation. Human MSC are demonstrated to express the immunosuppressive cytokines hepatocyte growth factor (HGF), interleukin (IL)-10 and trans... ... hiện toàn bộ
Tập 149 Số 2 - Trang 353-363 - 2007
Tumour necrosis factor (TNF) gene polymorphism influences TNF-α production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humansSUMMARY TNF-α is involved in infectious and immuno-inflammatory diseases. Different individuals may have different capacities for TNF-α production. This might determine a predisposition to develop some complications or phenotypes of these diseases. The aims of our study were to assess the inter-individual variability of TNF-α production and to correlate this variabi... ... hiện toàn bộ
Tập 113 Số 3 - Trang 401-406 - 2001
A marked difference in pathogenesis and immune response induced by differentMycobacterium tuberculosisgenotypesSUMMARY In the last decade, an unprecedented genetic diversity has been disclosed among Mycobacterium tuberculosis strains found worldwide. However, well-conserved genotypes seem to prevail in areas with high incidence of tuberculosis. As this may be related to selective advantages, such as advanced mechanisms to circumvent [M. bovis Bacille Calmette–Guerin (BCG)-in... ... hiện toàn bộ
Tập 133 Số 1 - Trang 30-37 - 2003
Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsiaSUMMARY We calculated the percentage of Th1, Th2, Th0 cells and the Th1:Th2 cell ratio of peripheral blood from normal pregnant subjects and preeclampsia patients using flow cytometry which can analyse both the surface marker, CD4, and intracellular cytokines, interleukin (IL)-4 and interferon (IFN)-γ. In normal pregnancy, the percentage of Th1 cells was significant... ... hiện toàn bộ
Tập 117 Số 3 - Trang 550-555 - 2001
Immunopathogenic mechanisms in psoriasisSUMMARY Psoriasis is a common autoimmune skin disease characterized by T cell-mediated hyperproliferation of keratinocytes. The disease has a strong but complex genetic background with a concordance of approximately 60% in monozygotic twins, and recent linkage and high resolution association studies indicate that HLA-Cw*0602 is itself a major susceptibility allele f... ... hiện toàn bộ
Tập 135 Số 1 - Trang 1-8 - 2003
The number of human peripheral blood CD4+ CD25high regulatory T cells increases with ageSummary Ageing is associated with evidence of immune deficiency and dysregulation. Key changes in the immune system with ageing include a progressive reduction in naive T cell output associated with thymic involution and peripheral expansion of oligoclonal memory T cells. These features are associated with evidence of impaired immune responsiveness both in vitro and... ... hiện toàn bộ
Tập 140 Số 3 - Trang 540-546 - 2005