Clinical and Experimental Immunology
SCOPUS (1966-2025)SCIE-ISI
0009-9104
1365-2249
Anh Quốc
Cơ quản chủ quản: OXFORD UNIV PRESS , Oxford University Press
Lĩnh vực:
Immunology and AllergyImmunology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
T cells in multiple sclerosis and experimental autoimmune encephalomyelitis
Tập 162 Số 1 - Trang 1-11 - 2010
SummaryMultiple sclerosis (MS) is a demyelinating inflammatory disorder of the
central nervous system (CNS), which involves autoimmune responses to myelin
antigens. Studies in experimental autoimmune encephalomyelitis (EAE), an animal
model for MS, have provided convincing evidence that T cells specific for
self-antigens mediate pathology in these diseases. Until recently, T helper type
1 (Th1) ce...
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease
Tập 148 Số 1 - Trang 32-46 - 2007
SummaryUncommitted (naive) murine CD4+ T helper cells (Thp) can be induced to
differentiate towards T helper 1 (Th1), Th2, Th17 and regulatory (Treg)
phenotypes according to the local cytokine milieu. This can be demonstrated most
readily both in vitro and in vivo in murine CD4+ T cells. The presence of
interleukin (IL)-12 [signalling through signal transduction and activator of
transcription (STA...
Analysis of islet inflammation in human type 1 diabetes
Tập 155 Số 2 - Trang 173-181 - 2009
Summary The immunopathology of type 1 diabetes (T1D) has proved difficult to
study in man because of the limited availability of appropriate samples, but we
now report a detailed study charting the evolution of insulitis in human T1D.
Pancreas samples removed post-mortem from 29 patients (mean age 11·7 years) with
recent-onset T1D were analysed by immunohistochemistry. The cell types
constituting ...
Cell contact, prostaglandin E2 and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25Highforkhead box P3+ regulatory T cells
Tập 156 Số 1 - Trang 149-160 - 2009
SummaryAdult human mesenchymal stromal or stem cells (MSC) can differentiate
into a variety of cell types and are candidate cellular therapeutics in
regenerative medicine. Surprisingly, these cells also display multiple potent
immunomodulatory capabilities, including allosuppression, making allogeneic cell
therapy a possibility. The exact mechanisms involved in regulatory T cell
induction by allog...
Interferon-γ does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells
Tập 149 Số 2 - Trang 353-363 - 2007
SummaryThe ability of mesenchymal stem cells (MSC) to suppress
alloresponsiveness is poorly understood. Herein, an allogeneic mixed lymphocyte
response was used as a model to investigate the mechanisms of MSC-mediated
immunomodulation. Human MSC are demonstrated to express the immunosuppressive
cytokines hepatocyte growth factor (HGF), interleukin (IL)-10 and transforming
growth factor (TGF)-β1 at...
Tumour necrosis factor (TNF) gene polymorphism influences TNF-α production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans
Tập 113 Số 3 - Trang 401-406 - 2001
SUMMARYTNF-α is involved in infectious and immuno-inflammatory diseases.
Different individuals may have different capacities for TNF-α production. This
might determine a predisposition to develop some complications or phenotypes of
these diseases. The aims of our study were to assess the inter-individual
variability of TNF-α production and to correlate this variability to a single
base pair polymo...
A marked difference in pathogenesis and immune response induced by differentMycobacterium tuberculosisgenotypes
Tập 133 Số 1 - Trang 30-37 - 2003
SUMMARYIn the last decade, an unprecedented genetic diversity has been disclosed
among Mycobacterium tuberculosis strains found worldwide. However,
well-conserved genotypes seem to prevail in areas with high incidence of
tuberculosis. As this may be related to selective advantages, such as advanced
mechanisms to circumvent [M. bovis Bacille Calmette–Guerin (BCG)-induced] host
defence mechanisms, w...
Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia
Tập 117 Số 3 - Trang 550-555 - 2001
SUMMARYWe calculated the percentage of Th1, Th2, Th0 cells and the Th1:Th2 cell
ratio of peripheral blood from normal pregnant subjects and preeclampsia
patients using flow cytometry which can analyse both the surface marker, CD4,
and intracellular cytokines, interleukin (IL)-4 and interferon (IFN)-γ. In
normal pregnancy, the percentage of Th1 cells was significantly lower in the
third trimester, ...
Immunopathogenic mechanisms in psoriasis
Tập 135 Số 1 - Trang 1-8 - 2003
SUMMARYPsoriasis is a common autoimmune skin disease characterized by T
cell-mediated hyperproliferation of keratinocytes. The disease has a strong but
complex genetic background with a concordance of approximately 60% in
monozygotic twins, and recent linkage and high resolution association studies
indicate that HLA-Cw*0602 is itself a major susceptibility allele for psoriasis.
Patients carrying t...
The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age
Tập 140 Số 3 - Trang 540-546 - 2005
SummaryAgeing is associated with evidence of immune deficiency and
dysregulation. Key changes in the immune system with ageing include a
progressive reduction in naive T cell output associated with thymic involution
and peripheral expansion of oligoclonal memory T cells. These features are
associated with evidence of impaired immune responsiveness both in vitro and in
vivo, termed immune senescenc...