Clinical and Experimental Immunology
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The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age
Clinical and Experimental Immunology - Tập 140 Số 3 - Trang 540-546 - 2005
SummaryAgeing is associated with evidence of immune deficiency and
dysregulation. Key changes in the immune system with ageing include a
progressive reduction in naive T cell output associated with thymic involution
and peripheral expansion of oligoclonal memory T cells. These features are
associated with evidence of impaired immune responsiveness both in vitro and in
vivo, termed immune senescenc...
Decreased CD4 and increased CD8 counts with T cell activation is associated with chronic helminth infection
Clinical and Experimental Immunology - Tập 114 Số 3 - Trang 414-421 - 2001
SUMMARYWe have previously reported the presence of marked immune dysregulation
with a dominant Th2 profile, in a population of Ethiopian immigrants (ETH) in
Israel heavily infected with helminths. In order to characterize better this
immune dysregulation we studied by flow cytometry the expression of several
activation markers on peripheral T cell populations, and lymphocyte apoptosis,
in blood sa...
Optimizing dendritic cell vaccine for immunotherapy in multiple myeloma: tumour lysates are more potent tumour antigens than idiotype protein to promote anti-tumour immunity
Clinical and Experimental Immunology - Tập 170 Số 2 - Trang 167-177 - 2012
SummaryDendritic cells (DCs) are the most potent antigen-presenting cells and
are the mediators of T cell immunity. Many investigators have explored the
potential of using DCs as a vaccine for tumour-derived antigens in immunotherapy
of B cell malignancies, and the results have been disappointing. To search for
better tumour antigens to improve the efficacy of DC-based immunotherapy in
myeloma, we...
Neutrophilic myeloid-derived suppressor cells in cord blood modulate innate and adaptive immune responses
Clinical and Experimental Immunology - Tập 174 Số 1 - Trang 45-52 - 2013
Summary Neonates show an impaired anti-microbial host defence, but the
underlying immune mechanisms are not understood fully. Myeloid-derived
suppressor cells (MDSCs) represent an innate immune cell subset characterized by
their capacity to suppress T cell immunity. In this study we demonstrate that a
distinct MDSC subset with a neutrophilic/granulocytic phenotype (Gr-MDSCs) is
highly increased in...
Does soluble triggering receptor expressed on myeloid cells-1 play any role in the pathogenesis of septic shock?
Clinical and Experimental Immunology - Tập 142 Số 1 - Trang 62-67 - 2005
Summary In order to define the significance of soluble triggering receptor
expressed on myeloid cells-1 (sTREM-1) upon progression from sepsis or severe
sepsis to septic shock a prospective study was designed with 90 enrolled
patients with septic syndrome due to ventilator-associated pneumonia. Blood was
sampled on seven consecutive days upon initiation of symptoms and concentrations
of tumour nec...
Evidence for extrathymic T cell maturation after thymectomy in infancy
Clinical and Experimental Immunology - Tập 145 Số 3 - Trang 407-412 - 2006
Summary Our previous study showed that children who had been partially or
completely thymectomized during heart surgery as infants had lower proportions
and numbers of total lymphocytes and reduced proportions of T cells (CD3+),
helper T cells (CD4+) and naive T cells (CD3+ CD4+ CD45RA+), but normal
proportion of cytotoxic T cells (CD8+). In this study T lymphocytes from a
selected group of eight ...
TH1/TH2 cytokine profile, metalloprotease-9 activity and hormonal status in pregnant rheumatoid arthritis and systemic lupus erythematosus patients
Clinical and Experimental Immunology - Tập 131 Số 2 - Trang 377-384 - 2003
SUMMARYDuring the course of rheumatoid arthritis (RA) and systemic lupus
erythematosus (SLE), several immune and neuroendocrine changes associated with
pregnancy may exert positive (amelioration) or negative (exacerbation) effects
on the clinical outcome. In order to shed light on the mechanisms underlying
these responses, we performed a prospective longitudinal study in RA and SLE
pregnant women,...
Longitudinal analysis of immune function in the first 3 years of life in thymectomized neonates during cardiac surgery
Clinical and Experimental Immunology - Tập 154 Số 3 - Trang 375-383 - 2008
SummaryThe purpose of this study is to evaluate the effects of neonatal
thymectomy in the functional capacity of the immune system. We selected a group
of 23 subjects, who had undergone thymectomy in their first 30 days of life,
during an intervention for congenital heart disease. Several parameters of the
immune system were evaluated during their first 3 years of life. Lymphocyte
populations and ...
Activity of matrix metalloproteinase-9 is elevated in sera of patients with systemic lupus erythematosus
Clinical and Experimental Immunology - Tập 127 Số 2 - Trang 393-398 - 2002
SummarySystemic lupus erythematosus (SLE) is an autoimmune disease characterized
by the increased production of autoantibodies and by systemic clinical
manifestations and damage to multiple organs. The aim of the present study was
to analyse matrix metalloproteinase (MMP)-9 activity in sera of patients with
active and inactive SLE in order to evaluate its role in the pathogenesis and
course of the...
The influence of partial or total thymectomy during open heart surgery in infants on the immune function later in life
Clinical and Experimental Immunology - Tập 136 Số 2 - Trang 349-355 - 2004
SUMMARY Infants undergoing open heart surgery often have all or part of their
thymus removed. The activity of the immune system has not been investigated
thoroughly in these children, and only shortly after the operation. Therefore,
it was decided to investigate the activity of the immune system in more detail
in children several years after their operation. Peripheral blood samples from
19 childr...
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