Clinical and Experimental Immunology

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Optimizing dendritic cell vaccine for immunotherapy in multiple myeloma: tumour lysates are more potent tumour antigens than idiotype protein to promote anti-tumour immunity
Clinical and Experimental Immunology - Tập 170 Số 2 - Trang 167-177 - 2012
Shengqian Hong, H Li, Jianfei Qian, Jian Yang, Yong Lu, Qing Yi
SummaryDendritic cells (DCs) are the most potent antigen-presenting cells and are the mediators of T cell immunity. Many investigators have explored the potential of using DCs as a vaccine for tumour-derived antigens in immunotherapy of B cell malignancies, and the results have been disappointing. To search for better tumour antigens to improve the efficacy of DC-b...... hiện toàn bộ
The influence of partial or total thymectomy during open heart surgery in infants on the immune function later in life
Clinical and Experimental Immunology - Tập 136 Số 2 - Trang 349-355 - 2004
Jenna Huld Eysteinsdóttir, Jona Freysdóttir, Ásgeir Haraldsson, Jenna Stefansdottir, I. Skaftadóttir, Hróðmar Helgason, Helga M. Ögmundsdóttir
SUMMARY Infants undergoing open heart surgery often have all or part of their thymus removed. The activity of the immune system has not been investigated thoroughly in these children, and only shortly after the operation. Therefore, it was decided to investigate the activity of the immune system in more detail in children several years after their op...... hiện toàn bộ
Intrinsic defect of the immune system in children with Down syndrome: a review
Clinical and Experimental Immunology - Tập 156 Số 2 - Trang 189-193 - 2009
Maaike A. Kusters, Ruud H J Verstegen, Eugenie Gemen, Esther de Vries
SummaryDown syndrome (DS) is the most frequent cause of mental retardation in man. Immunological changes in DS have been observed since the 1970s. The neurological system appears to be ageing precociously, with early occurrence of Alzheimer disease; until now, the observed immunological differences have been interpreted in the same context. Looking back at past and...... hiện toàn bộ
Microarray analysis of human milk cells: persistent high expression of osteopontin during the lactation period
Clinical and Experimental Immunology - Tập 138 Số 1 - Trang 47-53 - 2004
T. Nagatomo, Shouichi Ohga, Hidetoshi Takada, A Nomura, Shunji Hikino, Mitsuo Imura, Koichi Ohshima, Toshiro Hara
SUMMARYTo continue the search for immunological roles of breast milk, cDNA microarray analysis on cytokines and growth factors was performed for human milk cells. Among the 240 cytokine-related genes, osteopontin (OPN) gene ranked top of the expression. Real-time PCR revealed that the OPN mRNA levels in colostrum cells were approximately 100 times higher than those...... hiện toàn bộ
The Th1/Th2 cytokine balance changes with the progress of the immunopathological lesion of Sjogren's syndrome
Clinical and Experimental Immunology - Tập 128 Số 3 - Trang 562-568 - 2002
Dimitris I. Mitsias, Athanasios G. Tzioufas, CI Veiopoulou, Ηλίας Ζιντζαράς, Ioannis Tassios, Olga Kogopoulou, H M Moutsopoulos, Georges Thyphronitis
SUMMARYExpression of type-1 and type-2 cytokines at the mRNA level in labial salivary glands (LSG) of patients with Sjogren's syndrome (SS), as reported by several groups, have generated conflicting results. In the present study we have directly examined the production of IL-4, IL-13 and IFN-γ by lymphocytes infiltrating the LSG of 44 consecutive patients referred ...... hiện toàn bộ
Immunosuppressive properties of human amniotic membrane for mixed lymphocyte reaction
Clinical and Experimental Immunology - Tập 129 Số 3 - Trang 464-470 - 2002
Mayumi Ueta, M-N Kweon, Y Sano, Chie Sotozono, Jun Yamada, Noriko Koizumi, Hiroshi Kiyono, Shigeru Kinoshita
SUMMARYThe combination of allograft limbal transplantation (ALT) and amniotic membrane transplantation (AMT) has been applied in the treatment of severe ocular surface diseases. The beneficial effect of this combination has been thought to result from possible immunosuppressive ability of amniotic membrane (AM). However, the mechanisms of any such ability remain un...... hiện toàn bộ
Current insights into the role of human β-defensins in atopic dermatitis
Clinical and Experimental Immunology - Tập 190 Số 2 - Trang 155-166 - 2017
Panjit Chieosilapatham, Hisahito Ogawa, François Niyonsaba
Summary Anti-microbial peptides or host defence peptides are small molecules that display both anti-microbial activities and complex immunomodulatory functions to protect against various diseases. Among these peptides, the human β-defensins (hBDs) are localized primarily in epithelial surfaces, including those of the skin, where they contribute to pr...... hiện toàn bộ
Increased levels of IL-13 mRNA, but not IL-4 mRNA, are found in vivo in peripheral blood mononuclear cells (PBMC) of patients with atopic dermatitis (AD)
Clinical and Experimental Immunology - Tập 108 Số 2 - Trang 289-294 - 2003
Kazumoto Katagiri, Satoshi Itami, Yutaka Hatano, Susumu Takayasu
SUMMARY Previous studies using in vitro systems with various stimuli have shown that PBMC from patients with AD show increased levels of IL-4 but decreased levels of interferon-gamma (IFN-γ) compared with PBMC from normal controls. However, in vitro conditions do not always mimic the in vivo condition. We therefore believe that it is important to qua...... hiện toàn bộ
Reduced production of both Th1 and Tc1 lymphocyte subsets in atopic dermatitis (AD)
Clinical and Experimental Immunology - Tập 115 Số 1 - Trang 1-5 - 2001
Antonietta Lonati, Stefano Licenziati, Angelo Donato Canaris, Simona Fiorentini, Giorgio Pasolini, Marco Marcelli, Stefania Seidenari, Arnaldo Caruso, G. De Panfilis
SUMMARYAn imbalance of interferon-gamma (IFN-γ)-bearing CD4+ T (Th1) cells in the pathogenesis of AD is well recognized; however, a possible role in AD for CD8+ T cells secreting Th1-like cytokines (Tc1) has not been properly addressed. In this study, two- and three-colour FACS analysis allowed us to discriminate the Th1 from the Tc1 subset. AD patients had half th...... hiện toàn bộ
Early environmental factors and rheumatoid arthritis
Clinical and Experimental Immunology - Tập 143 Số 1 - Trang 1-5 - 2005
Christopher J Edwards, Cyrus Cooper
Summary The precise cause of autoimmune diseases such as rheumatoid arthritis (RA) remains uncertain. In recent years there has been extensive investment in pursuing genes important in RA. However, estimates suggest that the risk of developing RA is at most 50% determined by genes. There has been limited success defining the environmental factors imp...... hiện toàn bộ
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