Clinical and Experimental Immunology

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The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age
Clinical and Experimental Immunology - Tập 140 Số 3 - Trang 540-546 - 2005
Randal K. Gregg, Christopher M. Smith, Fiona Clark, Debbie Dunnion, Naeem Khan, Ronjon Chakraverty, Laxman Nayak, Paul Moss
SummaryAgeing is associated with evidence of immune deficiency and dysregulation. Key changes in the immune system with ageing include a progressive reduction in naive T cell output associated with thymic involution and peripheral expansion of oligoclonal memory T cells. These features are associated with evidence of impaired immune responsiveness both in vitro and...... hiện toàn bộ
Optimizing dendritic cell vaccine for immunotherapy in multiple myeloma: tumour lysates are more potent tumour antigens than idiotype protein to promote anti-tumour immunity
Clinical and Experimental Immunology - Tập 170 Số 2 - Trang 167-177 - 2012
Shengqian Hong, H Li, Jianfei Qian, Jian Yang, Yong Lu, Qing Yi
SummaryDendritic cells (DCs) are the most potent antigen-presenting cells and are the mediators of T cell immunity. Many investigators have explored the potential of using DCs as a vaccine for tumour-derived antigens in immunotherapy of B cell malignancies, and the results have been disappointing. To search for better tumour antigens to improve the efficacy of DC-b...... hiện toàn bộ
Neutrophilic myeloid-derived suppressor cells in cord blood modulate innate and adaptive immune responses
Clinical and Experimental Immunology - Tập 174 Số 1 - Trang 45-52 - 2013
Nikolaus Rieber, Christian Gille, Natascha Köstlin‐Gille, Iris Schäfer, Bärbel Spring, Michael C. Ost, Helen Spieles, Hellen Kugel, Matthias Pfeiffer, Vanessa Heininger, Mohammed Alkhaled, Andreas Hector, Lauren Mays, Michael Kormann, Sabine Zundel, Jörg Fuchs, Rupert Handgretinger, Christian F. Poets, Dominik Hartl
Summary Neonates show an impaired anti-microbial host defence, but the underlying immune mechanisms are not understood fully. Myeloid-derived suppressor cells (MDSCs) represent an innate immune cell subset characterized by their capacity to suppress T cell immunity. In this study we demonstrate that a distinct MDSC subset with a neutrophilic/granuloc...... hiện toàn bộ
Does soluble triggering receptor expressed on myeloid cells-1 play any role in the pathogenesis of septic shock?
Clinical and Experimental Immunology - Tập 142 Số 1 - Trang 62-67 - 2005
Christina Routsi, Evangelos J. Giamarellos‐Bourboulis, Anastasia Antonopoulou, Spyridon Kollias, Sofia Siasiakou, Apostolos Koronaios, Spyridon Zakynthinos, Apostolos Armaganidis, Helen Giamarellou, Charis Roussos
Summary In order to define the significance of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) upon progression from sepsis or severe sepsis to septic shock a prospective study was designed with 90 enrolled patients with septic syndrome due to ventilator-associated pneumonia. Blood was sampled on seven consecutive days upon initiat...... hiện toàn bộ
Evidence for extrathymic T cell maturation after thymectomy in infancy
Clinical and Experimental Immunology - Tập 145 Số 3 - Trang 407-412 - 2006
H Torfadottir, Jona Freysdóttir, I. Skaftadóttir, Ásgeir Haraldsson, Gunnlaugur Sigfússon, Helga M. Ögmundsdóttir
Summary Our previous study showed that children who had been partially or completely thymectomized during heart surgery as infants had lower proportions and numbers of total lymphocytes and reduced proportions of T cells (CD3+), helper T cells (CD4+) and naive T cells (CD3+ CD4+ CD45RA+), but normal proportion of cytotoxic T cells (CD8+). In this stu...... hiện toàn bộ
TH1/TH2 cytokine profile, metalloprotease-9 activity and hormonal status in pregnant rheumatoid arthritis and systemic lupus erythematosus patients
Clinical and Experimental Immunology - Tập 131 Số 2 - Trang 377-384 - 2003
José Francisco Muñoz‐Valle, Mónica Vázquez-Del Mercado, Trinidad García‐Iglesias, Gerardo Orozco‐Barocio, G. Bernard-Medina, Gloria Martínez-Bonilla, Blanca Estela Bastidas‐Ramírez, ́Adrián Daneri-Navarro, Miriam Ruth Bueno‐Topete, Erika Martínez‐López, Carlos Best‐Aguilera, Makoto Kamachi, Juan Armendáriz‐Borunda
SUMMARYDuring the course of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), several immune and neuroendocrine changes associated with pregnancy may exert positive (amelioration) or negative (exacerbation) effects on the clinical outcome. In order to shed light on the mechanisms underlying these responses, we performed a prospective longitudinal st...... hiện toàn bộ
Longitudinal analysis of immune function in the first 3 years of life in thymectomized neonates during cardiac surgery
Clinical and Experimental Immunology - Tập 154 Số 3 - Trang 375-383 - 2008
Esther Mancebo, J Clemente, Juan Manuel Sepúlveda, Jesús Ruíz-Contreras, Paloma de Pablos, S Cortezon, E Romo, Estela Paz‐Artal, Luís M. Allende
SummaryThe purpose of this study is to evaluate the effects of neonatal thymectomy in the functional capacity of the immune system. We selected a group of 23 subjects, who had undergone thymectomy in their first 30 days of life, during an intervention for congenital heart disease. Several parameters of the immune system were evaluated during their first 3 years of ...... hiện toàn bộ
Activity of matrix metalloproteinase-9 is elevated in sera of patients with systemic lupus erythematosus
Clinical and Experimental Immunology - Tập 127 Số 2 - Trang 393-398 - 2002
Anat Faber-Elmann, Zev Sthoeger, A TCHERNIACK, Molly Dayan, Edna Mozes
SummarySystemic lupus erythematosus (SLE) is an autoimmune disease characterized by the increased production of autoantibodies and by systemic clinical manifestations and damage to multiple organs. The aim of the present study was to analyse matrix metalloproteinase (MMP)-9 activity in sera of patients with active and inactive SLE in order to evaluate its role in t...... hiện toàn bộ
The influence of partial or total thymectomy during open heart surgery in infants on the immune function later in life
Clinical and Experimental Immunology - Tập 136 Số 2 - Trang 349-355 - 2004
Jenna Huld Eysteinsdóttir, Jona Freysdóttir, Ásgeir Haraldsson, Jenna Stefansdottir, I. Skaftadóttir, Hróðmar Helgason, Helga M. Ögmundsdóttir
SUMMARY Infants undergoing open heart surgery often have all or part of their thymus removed. The activity of the immune system has not been investigated thoroughly in these children, and only shortly after the operation. Therefore, it was decided to investigate the activity of the immune system in more detail in children several years after their op...... hiện toàn bộ
Intrinsic defect of the immune system in children with Down syndrome: a review
Clinical and Experimental Immunology - Tập 156 Số 2 - Trang 189-193 - 2009
Maaike A. Kusters, Ruud H J Verstegen, Eugenie Gemen, Esther de Vries
SummaryDown syndrome (DS) is the most frequent cause of mental retardation in man. Immunological changes in DS have been observed since the 1970s. The neurological system appears to be ageing precociously, with early occurrence of Alzheimer disease; until now, the observed immunological differences have been interpreted in the same context. Looking back at past and...... hiện toàn bộ
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