Clinical and Experimental Immunology

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Optimizing dendritic cell vaccine for immunotherapy in multiple myeloma: tumour lysates are more potent tumour antigens than idiotype protein to promote anti-tumour immunity
Clinical and Experimental Immunology - Tập 170 Số 2 - Trang 167-177 - 2012
Shengqian Hong, H Li, Jianfei Qian, Jian Yang, Yong Lu, Qing Yi
SummaryDendritic cells (DCs) are the most potent antigen-presenting cells and are the mediators of T cell immunity. Many investigators have explored the potential of using DCs as a vaccine for tumour-derived antigens in immunotherapy of B cell malignancies, and the results have been disappointing. To search for better tumour antigens to improve the efficacy of DC-b...... hiện toàn bộ
The influence of partial or total thymectomy during open heart surgery in infants on the immune function later in life
Clinical and Experimental Immunology - Tập 136 Số 2 - Trang 349-355 - 2004
Jenna Huld Eysteinsdóttir, Jona Freysdóttir, Ásgeir Haraldsson, Jenna Stefansdottir, I. Skaftadóttir, Hróðmar Helgason, Helga M. Ögmundsdóttir
SUMMARY Infants undergoing open heart surgery often have all or part of their thymus removed. The activity of the immune system has not been investigated thoroughly in these children, and only shortly after the operation. Therefore, it was decided to investigate the activity of the immune system in more detail in children several years after their op...... hiện toàn bộ
Intrinsic defect of the immune system in children with Down syndrome: a review
Clinical and Experimental Immunology - Tập 156 Số 2 - Trang 189-193 - 2009
Maaike A. Kusters, Ruud H J Verstegen, Eugenie Gemen, Esther de Vries
SummaryDown syndrome (DS) is the most frequent cause of mental retardation in man. Immunological changes in DS have been observed since the 1970s. The neurological system appears to be ageing precociously, with early occurrence of Alzheimer disease; until now, the observed immunological differences have been interpreted in the same context. Looking back at past and...... hiện toàn bộ
Microarray analysis of human milk cells: persistent high expression of osteopontin during the lactation period
Clinical and Experimental Immunology - Tập 138 Số 1 - Trang 47-53 - 2004
T. Nagatomo, Shouichi Ohga, Hidetoshi Takada, A Nomura, Shunji Hikino, Mitsuo Imura, Koichi Ohshima, Toshiro Hara
SUMMARYTo continue the search for immunological roles of breast milk, cDNA microarray analysis on cytokines and growth factors was performed for human milk cells. Among the 240 cytokine-related genes, osteopontin (OPN) gene ranked top of the expression. Real-time PCR revealed that the OPN mRNA levels in colostrum cells were approximately 100 times higher than those...... hiện toàn bộ
Interferon regulatory factor 3 as key element of the interferon signature in plasmacytoid dendritic cells from systemic lupus erythematosus patients: novel genetic associations in the Mexican mestizo population
Clinical and Experimental Immunology - Tập 178 Số 3 - Trang 428-437 - 2014
Karina Santana-de Anda, Diana Gómez-Martı́n, Adriana Monsiváis‐Urenda, Mariana Salgado‐Bustamante, Roberto González‐Amaro, Jorge Alcocer‐Varela
SummaryMany genetic studies have found an association between interferon regulatory factors (IRF) single nucleotide polymorphisms (SNPs) and systemic lupus erythematosus (SLE); however, specific dendritic cell (DC) alterations have not been assessed. The aim of the present study was to address the expression of IRF3 and IRF5 on different DC subsets from SLE patient...... hiện toàn bộ
The Th1/Th2 cytokine balance changes with the progress of the immunopathological lesion of Sjogren's syndrome
Clinical and Experimental Immunology - Tập 128 Số 3 - Trang 562-568 - 2002
Dimitris I. Mitsias, Athanasios G. Tzioufas, CI Veiopoulou, Ηλίας Ζιντζαράς, Ioannis Tassios, Olga Kogopoulou, H M Moutsopoulos, Georges Thyphronitis
SUMMARYExpression of type-1 and type-2 cytokines at the mRNA level in labial salivary glands (LSG) of patients with Sjogren's syndrome (SS), as reported by several groups, have generated conflicting results. In the present study we have directly examined the production of IL-4, IL-13 and IFN-γ by lymphocytes infiltrating the LSG of 44 consecutive patients referred ...... hiện toàn bộ
Transfection of single-stranded hepatitis A virus RNA activates MHC class I pathway
Clinical and Experimental Immunology - Tập 127 Số 2 - Trang 234-242 - 2002
Koichi Suzuki, Masayuki Yanagi, Atsumi Mori-Aoki, Emiko Moriyama, Ken J. Ishii, Leonard D. Kohn
SummaryAlthough infection of single-stranded RNA viruses can enhance expression of major histocompatibility complex (MHC) class I genes, the mechanism underlying this process remains unclear. Recent studies have indicated that exposure of non-immune cells to double-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) of viral origin can directly increase ...... hiện toàn bộ
The frequency of CLA+ CD8+ T cells in the blood of psoriasis patients correlates closely with the severity of their disease
Clinical and Experimental Immunology - Tập 126 Số 2 - Trang 365-369 - 2008
Hekla Sigmundsdóttir, Jóhann E. Guðjónsson, Ingileif Jónsdóttir, Björn R. Lúdvíksson, H Valdimarsson
SummaryPsoriasis is thought to be a T cell-mediated skin disease and the cutaneous lymphocyte antigen (CLA) is an important skin homing epitope for T cells. We have studied the relationship between disease severity (PASI) and phenotypic analysis of T cells in the blood of 36 patients with psoriasis focusing on the expression of CLA, VLA-4 and CD25 on CD4+ and CD8+ ...... hiện toàn bộ
Immunosuppressive properties of human amniotic membrane for mixed lymphocyte reaction
Clinical and Experimental Immunology - Tập 129 Số 3 - Trang 464-470 - 2002
Mayumi Ueta, M-N Kweon, Y Sano, Chie Sotozono, Jun Yamada, Noriko Koizumi, Hiroshi Kiyono, Shigeru Kinoshita
SUMMARYThe combination of allograft limbal transplantation (ALT) and amniotic membrane transplantation (AMT) has been applied in the treatment of severe ocular surface diseases. The beneficial effect of this combination has been thought to result from possible immunosuppressive ability of amniotic membrane (AM). However, the mechanisms of any such ability remain un...... hiện toàn bộ
Rapid subcutaneous immunoglobulin administration every second week results in high and stable serum immunoglobulin G levels in patients with primary antibody deficiencies
Clinical and Experimental Immunology - Tập 152 Số 2 - Trang 274-279 - 2008
R Gustafson, Ann Gardulf, Susanne Vinkel Koch, Heinz Leibl, Werner Engl, Magdalena Lindén, Anne Müller, Lennart Hammarström
Summary Subcutaneous immunoglobulin G (SCIG) infusions as life-long replacement therapy in patients with primary antibody deficiences (PAD) is being applied increasingly. However, only a few published pharmacokinetic studies are available for this route of administration. Therefore, the pharmacokinetics of a 16% immunoglobulin G (IgG) preparation int...... hiện toàn bộ
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