Clinical and Experimental Immunology

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Decreased CD4 and increased CD8 counts with T cell activation is associated with chronic helminth infection
Clinical and Experimental Immunology - Tập 114 Số 3 - Trang 414-421 - 2001
Alexander Kalinkovich, Z Weisman, Zachary Greenberg, J Nahmias, S Eitan, Miguel Stein, Zák R
SUMMARYWe have previously reported the presence of marked immune dysregulation with a dominant Th2 profile, in a population of Ethiopian immigrants (ETH) in Israel heavily infected with helminths. In order to characterize better this immune dysregulation we studied by flow cytometry the expression of several activation markers on peripheral T cell populations, and ...... hiện toàn bộ
Tăng sinh CD8 lymphocyt trong nhiễm virus cytomegalovirus (CMV) nguyên phát ở người nhận ghép tạng: sự mở rộng của một phân nhóm CD8+ CD57− không phổ biến và sự thay thế tiến triển của nó bằng các tế bào T CD8+CD57+ Dịch bởi AI
Clinical and Experimental Immunology - Tập 95 Số 3 - Trang 465-471 - 2008
Myriam Labalette, F. Salez, F.-R. Pruvot, C. Noël, J.P. Dessaint
TÓM TẮTCác người nhận ghép tạng bị nhiễm virus cytomegalovirus (CMV) có tỷ lệ tế bào lympho CD8+ tuần hoàn tăng lên. Một nghiên cứu theo chiều dọc trên 11 người nhận ghép thận và 5 người nhận ghép gan có nhiễm CMV nguyên phát nhưng không có yếu tố nguyên nhân nào khác gây ra rối loạn chức năng ghép cho thấy sự mất cân bằng chọn lọc của các phân nhóm T tế bào CD8+ t...... hiện toàn bộ
Increased levels of IL-13 mRNA, but not IL-4 mRNA, are found in vivo in peripheral blood mononuclear cells (PBMC) of patients with atopic dermatitis (AD)
Clinical and Experimental Immunology - Tập 108 Số 2 - Trang 289-294 - 2003
Kazumoto Katagiri, Satoshi Itami, Yutaka Hatano, Susumu Takayasu
SUMMARY Previous studies using in vitro systems with various stimuli have shown that PBMC from patients with AD show increased levels of IL-4 but decreased levels of interferon-gamma (IFN-γ) compared with PBMC from normal controls. However, in vitro conditions do not always mimic the in vivo condition. We therefore believe that it is important to qua...... hiện toàn bộ
Possible pathogenic role of T helper type 9 cells and interleukin (IL)-9 in atopic dermatitis
Clinical and Experimental Immunology - Tập 175 Số 1 - Trang 25-31 - 2013
Lei Ma, H-B Xue, X-H Guan, C-M Shu, J-H Zhang, Jianxiu Yu
SummaryT helper type 9 (Th9) cells are a novel identified subset of CD4+ T helper cells, which could partly contribute to allergic inflammation, while the precise contribution of Th9 cells in atopic dermatitis (AD) remains unknown. We aimed to explore the possible role of Th9 cells in AD pathogenesis. The Th9 cell percentage, transcription factor PU.1 and cytokine ...... hiện toàn bộ
Reduced production of both Th1 and Tc1 lymphocyte subsets in atopic dermatitis (AD)
Clinical and Experimental Immunology - Tập 115 Số 1 - Trang 1-5 - 2001
Antonietta Lonati, Stefano Licenziati, Angelo Donato Canaris, Simona Fiorentini, Giorgio Pasolini, Marco Marcelli, Stefania Seidenari, Arnaldo Caruso, G. De Panfilis
SUMMARYAn imbalance of interferon-gamma (IFN-γ)-bearing CD4+ T (Th1) cells in the pathogenesis of AD is well recognized; however, a possible role in AD for CD8+ T cells secreting Th1-like cytokines (Tc1) has not been properly addressed. In this study, two- and three-colour FACS analysis allowed us to discriminate the Th1 from the Tc1 subset. AD patients had half th...... hiện toàn bộ
CD4+ and CD8+ clonal T cell expansions indicate a role of antigens inankylosing spondylitis; a study in HLA-B27+ monozygotic twins
Clinical and Experimental Immunology - Tập 123 Số 2 - Trang 315-322 - 2001
Rainer Duchmann, Carsten Lambert, Ekkehard May, Thomas Höhler, E. Märker‐Hermann
SUMMARYAnkylosing spondylitis (AS) is a complex genetic disease in which both MHC and non-MHC genes determine disease susceptibility. To determine whether the T cell repertoires of individuals with AS show signs of increased stimulation by exogenous antigens, CD4+ and CD8+ T cell subsets of five monozygotic HLA-B27+ twins (two concordant and three discordant for AS...... hiện toàn bộ
Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components
Clinical and Experimental Immunology - Tập 169 Số 1 - Trang 38-48 - 2012
Steffen Thiel, Louise N. Jensen, Søren E. Degn, Hans Jørgen Nielsen, Péter Gál, József Dobó, Jens C. Jensenius
Summary The pattern-recognition molecules mannan-binding lectin (MBL) and the three ficolins circulate in blood in complexes with MBL-associated serine proteases (MASPs). When MBL or ficolin recognizes a microorganism, activation of the MASPs occurs leading to activation of the complement system, an important component of the innate immune system. Th...... hiện toàn bộ
Plasma levels of mannan-binding lectin (MBL)-associated serine proteases (MASPs) and MBL-associated protein in cardio- and cerebrovascular diseases
Clinical and Experimental Immunology - Tập 173 Số 1 - Trang 112-120 - 2013
V. Frauenknecht, Steffen Thiel, Line Storm, Niklaus Meier, Maria Arnold, JP Schmid, Hugo Saner, Verena Schroeder
Summary Growing evidence suggests a prominent role of the complement system in the pathogenesis of cardio- and cerebrovascular diseases (CVD). Mannan-binding lectin-associated serine proteases (MASPs) MASP-1 and MASP-2 of the complement lectin pathway contribute to clot formation and may represent an important link between inflammation and thrombosis...... hiện toàn bộ
TREC and KREC profiling as a representative of thymus and bone marrow output in patients with various inborn errors of immunity
Clinical and Experimental Immunology - Tập 202 Số 1 - Trang 60-71 - 2020
Majed Dasouki, Amal Jabr, Ghadah Aldakheel, Fahd El‐Badaoui, Anas M. Alazami, Bandar Al‐Saud, Rand Arnaout, Hasan Al‐Dhekri, Ibtihal Al-Otaibi, Hamoud Al‐Mousa, Abbas Hawwari
Summary Primary immune deficiency (PID) disorders are clinically and molecularly heterogeneous diseases. T cell receptor excision circles (TRECs) and κ (kappa)-deleting excision circles (KRECs) are markers of T and B cell development, respectively. They are useful tools to assess T and B cell function and immune reconstitution and have been used for ...... hiện toàn bộ
Nasal mucosa in natural colds: effects of allergic rhinitis and susceptibility to recurrent sinusitis
Clinical and Experimental Immunology - Tập 137 Số 2 - Trang 366-372 - 2004
O-P ALHO, R Karttunen, Tuomo J. Karttunen
SUMMARYThe mechanisms of virus-induced airway hyperresponsiveness in asthma and allergy and the failure of host defence in patients suffering from secondary airway infections are still largely unknown. The aim of this study was to examine whether the presence of allergic rhinitis or susceptibility to recurrent sinusitis affects the structural and cellular changes i...... hiện toàn bộ
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