Neutrophilic myeloid-derived suppressor cells in cord blood modulate innate and adaptive immune responses

Clinical and Experimental Immunology - Tập 174 Số 1 - Trang 45-52 - 2013
Nikolaus Rieber1, Christian Gille2, Natascha Köstlin‐Gille2, Iris Schäfer1, Bärbel Spring2, Michael C. Ost1, Helen Spieles2, Hellen Kugel2, Matthias Pfeiffer1, Vanessa Heininger1, Mohammed Alkhaled1, Andreas Hector1, Lauren Mays1, Michael Kormann1, Sabine Zundel3, Jörg Fuchs3, Rupert Handgretinger1, Christian F. Poets2, Dominik Hartl1
1Department of Pediatrics I, University of Tübingen, Tübingen, Germany
2Department of Pediatrics IV, University of Tübingen, Tübingen, Germany
3Department of Pediatric Surgery, University of Tübingen, Tübingen, Germany

Tóm tắt

Summary Neonates show an impaired anti-microbial host defence, but the underlying immune mechanisms are not understood fully. Myeloid-derived suppressor cells (MDSCs) represent an innate immune cell subset characterized by their capacity to suppress T cell immunity. In this study we demonstrate that a distinct MDSC subset with a neutrophilic/granulocytic phenotype (Gr-MDSCs) is highly increased in cord blood compared to peripheral blood of children and adults. Functionally, cord blood isolated Gr-MDSCs suppressed T cell proliferation efficiently as well as T helper type 1 (Th1), Th2 and Th17 cytokine secretion. Beyond T cells, cord blood Gr-MDSCs controlled natural killer (NK) cell cytotoxicity in a cell contact-dependent manner. These studies establish neutrophilic Gr-MDSCs as a novel immunosuppressive cell subset that controls innate (NK) and adaptive (T cell) immune responses in neonates. Increased MDSC activity in cord blood might serve as key fetomaternal immunosuppressive mechanism impairing neonatal host defence. Gr-MDSCs in cord blood might therefore represent a therapeutic target in neonatal infections.

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