Decreased CD4 and increased CD8 counts with T cell activation is associated with chronic helminth infection

Clinical and Experimental Immunology - Tập 114 Số 3 - Trang 414-421 - 2001
Alexander Kalinkovich1, Z Weisman2, Zachary Greenberg3, J Nahmias4, S Eitan2, Miguel Stein2, Zák R2
1Ben-Ari Institute of Clinical Immunology, AIDS Centre, Kaplan Medical Centre, Hebrew University Hadassah Medical School, Rehovot, Israel.
2Ben-Ari Institute of Clinical Immunology, AIDS Centre, Kaplan Medical Centre, Hebrew University Hadassah Medical School, Rehovot,
3Public Health Laboratory, Ministry of Health, Jerusalem,
4Zevulun Clinic, Kupat Holim, Kiryat Mozkin, Israel

Tóm tắt

SUMMARY

We have previously reported the presence of marked immune dysregulation with a dominant Th2 profile, in a population of Ethiopian immigrants (ETH) in Israel heavily infected with helminths. In order to characterize better this immune dysregulation we studied by flow cytometry the expression of several activation markers on peripheral T cell populations, and lymphocyte apoptosis, in blood samples obtained from 63 ‘new’ ETH (recently arrived), 18 ‘old’ ETH (> 5 years since immigration) and 34 non-Ethiopian Israelis. The main findings in the ‘new’ ETH group in comparison with the non-Ethiopian controls were: (i) decreased CD4 and increased CD8 lymphocyte counts; (ii) elevated levels of activated T cells (CD3, CD4 and CD8) expressing HLA-DR; (iii) decreased levels of ‘naive’ CD4+ cells (CD45RA+), with increased levels of ‘memory’ CD4+ cells (CD45RO+); (iv) decreased numbers of CD28+ CD8+ lymphocytes; (v) marked increase in lymphocyte apoptosis. These T cell alterations and activation profile remained unchanged in 10 ‘new’ ETH in whom the helminth infections persisted for 6–11 months. In contrast, in 18 ‘old’ ETH, without helminth infections, the T cell activation profile was within the normal range. These findings suggest that chronic helminth infections may have a profound effect on the immune system of the host that disappears after eradication of these infections and adjustment to the new environment. It should therefore be taken into consideration for every immunomodulation therapy and especially in vaccine design and trials, in regions endemic for helminth infections.

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Thông tin xuất bản

Clinical and Experimental Immunology

Tập 114 Số 3

414-421

Thông tin tác giả