ChemMedChem
SCIE-ISI SCOPUS (2006-2023)
1860-7187
1860-7179
Anh Quốc
Cơ quản chủ quản: WILEY-V C H VERLAG GMBH , John Wiley and Sons Ltd
Lĩnh vực:
BiochemistryMolecular MedicineDrug DiscoveryPharmacology, Toxicology and Pharmaceutics (miscellaneous)PharmacologyOrganic Chemistry
Các bài báo tiêu biểu
Topical Delivery of Silver Nanoparticles Promotes Wound HealingAbstract Wound healing is a complex process and has been the subject of intense research for a long time. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing remain unknown. We investigated the wound‐healing properti... ...
Tập 2 Số 1 - Trang 129-136 - 2007
Prodrug Strategies in Anticancer ChemotherapyAbstract The majority of clinically approved anticancer drugs are characterized by a narrow therapeutic window that results mainly from a high systemic toxicity of the drugs in combination with an evident lack of tumor selectivity. Besides the development of suitable galenic formulations such as liposomes or micelles, several promising prodrug approaches have been f... ...
Tập 3 Số 1 - Trang 20-53 - 2008
Dự đoán các thuộc tính ADMET Dịch bởi AI Tóm tắt Bài tổng quan này mô tả một số phương pháp và kỹ thuật hiện đang được sử dụng để đưa ra các mô hình in silico nhằm dự đoán các thuộc tính ADMET. Bài báo cũng thảo luận một số yêu cầu cơ bản đối với việc tạo ra các mối quan hệ ADMET có tính toán học có cơ sở thống kê và dự đoán, cũng như một số cạm bẫy và vấn đề đã gặp phải trong các nghiên cứu này. Ý định củ... ...
Tập 1 Số 9 - Trang 920-937 - 2006
#Dự đoán thuộc tính ADMET #mô hình in silico #phát triển thuốc #thống kê #phát hiện thử nghiệm #thách thức
Curcumin‐Derived Pyrazoles and Isoxazoles: Swiss Army Knives or Blunt Tools for Alzheimer's Disease?Abstract Curcumin binds to the amyloid β peptide (Aβ) and inhibits or modulates amyloid precursor protein (APP) metabolism. Therefore, curcumin‐derived isoxazoles and pyrazoles were synthesized to minimize the metal chelation properties of curcumin. The decreased rotational freedom and absence of stereoisomers was predicted to enhance affinity toward Aβ42<... ...
Tập 3 Số 1 - Trang 165-172 - 2008
Membrane‐Active Small Molecules: Designs Inspired by Antimicrobial PeptidesAbstract Infectious diseases continue to be one of the major contributors to human morbidity. The rapid rate at which pathogenic microorganisms have developed resistance against frontline antimicrobials has compelled scientists to look for new alternatives. Given their vast antimicrobial repertoire, substantial research effort has been dedicated toward the developme... ...
Tập 10 Số 10 - Trang 1606-1624 - 2015
Recent Advances in the Development of Indazole‐based Anticancer AgentsAbstract Cancer is one of the leading causes of human mortality globally; therefore, intensive efforts have been made to seek new active drugs with improved anticancer efficacy. Indazole‐containing derivatives are endowed with a broad range of biological properties, including anti‐inflammatory, antimicrobial, anti‐HIV, antihypertensive, and anticancer activities. In... ...
Tập 13 Số 15 - Trang 1490-1507 - 2018
Anticancer Activity of Silver–N‐Heterocyclic Carbene Complexes: Caspase‐Independent Induction of Apoptosis via Mitochondrial Apoptosis‐Inducing Factor (AIF)Abstract Fourteen silver(I) complexes bearing N ‐heterocyclic carbene (NHC) ligands were prepared and evaluated for anticancer activity. Some of these were found to exhibit potent antiproliferative activity toward several types of human cancer cell lines, including drug‐resistant cell lines, with IC50 values in the nano... ...
Tập 7 Số 5 - Trang 805-814 - 2012
Pharmacophore‐Based Discovery of Small‐Molecule Inhibitors of Protein–Protein Interactions between HIV‐1 Integrase and Cellular Cofactor LEDGF/p75Abstract The cellular protein lens epithelium‐derived growth factor, or transcriptional coactivator p75 (LEDGF/p75), plays a crucial role in HIV integration. The protein–protein interactions (PPIs) between HIV‐1 integrase (IN) and its cellular cofactor LEDGF/p75 may therefore serve as targets for the development of new anti‐HIV drugs. In this work, a st...
Tập 4 Số 8 - Trang 1311-1316 - 2009
From Modeling to Medicinal Chemistry: Automatic Generation of Two‐Dimensional Complex DiagramsAbstract As a result of the increasing application of structure‐based drug design, the visualization of protein–ligand complexes has become an important feature in medicinal chemistry. The large number of experimentally resolved complex structures and the further development of computer‐aided methods like docking or de novo design establishes new possibilities in th... ...
Tập 2 Số 6 - Trang 853-860 - 2007