Topical Delivery of Silver Nanoparticles Promotes Wound Healing Tập 2 Số 1 - Trang 129-136 - 2007
Jun Tian, Kenneth K. Wong, Connie Suk‐Han Ho, Chun‐Nam Lok, Wing‐Yiu Yu, Chi‐Ming Che, Jen‐Fu Chiu, Paul K. H. Tam
AbstractWound healing is a complex process and has been the subject of intense research for a long time. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing remain unknown. We investigated the wound‐healing properti...... hiện toàn bộ Prodrug Strategies in Anticancer Chemotherapy Tập 3 Số 1 - Trang 20-53 - 2008
Felix Kratz, Ivonne A. Müller, Claudia Ryppa, André Warnecke
AbstractThe majority of clinically approved anticancer drugs are characterized by a narrow therapeutic window that results mainly from a high systemic toxicity of the drugs in combination with an evident lack of tumor selectivity. Besides the development of suitable galenic formulations such as liposomes or micelles, several promising prodrug approaches have been f...... hiện toàn bộ Dự đoán các thuộc tính ADMET Dịch bởi AI Tập 1 Số 9 - Trang 920-937 - 2006
Ulf Norinder, Christel A. S. Bergström
Tóm tắtBài tổng quan này mô tả một số phương pháp và kỹ thuật hiện đang được sử dụng để đưa ra các mô hình in silico nhằm dự đoán các thuộc tính ADMET. Bài báo cũng thảo luận một số yêu cầu cơ bản đối với việc tạo ra các mối quan hệ ADMET có tính toán học có cơ sở thống kê và dự đoán, cũng như một số cạm bẫy và vấn đề đã gặp phải trong các nghiên cứu này. Ý định củ...... hiện toàn bộ #Dự đoán thuộc tính ADMET #mô hình in silico #phát triển thuốc #thống kê #phát hiện thử nghiệm #thách thức
Curcumin‐Derived Pyrazoles and Isoxazoles: Swiss Army Knives or Blunt Tools for Alzheimer's Disease? Tập 3 Số 1 - Trang 165-172 - 2008
Rajeshwar Narlawar, Marcus Pickhardt, Stefanie Leuchtenberger, Karlheinz Baumann, Sabine Krause, Thomas Dyrks, Sascha Weggen, Eckhard Mandelkow�, Boris Schmidt
AbstractCurcumin binds to the amyloid β peptide (Aβ) and inhibits or modulates amyloid precursor protein (APP) metabolism. Therefore, curcumin‐derived isoxazoles and pyrazoles were synthesized to minimize the metal chelation properties of curcumin. The decreased rotational freedom and absence of stereoisomers was predicted to enhance affinity toward Aβ42<...... hiện toàn bộ Membrane‐Active Small Molecules: Designs Inspired by Antimicrobial Peptides Tập 10 Số 10 - Trang 1606-1624 - 2015
Chandradhish Ghosh, Jayanta Haldar
AbstractInfectious diseases continue to be one of the major contributors to human morbidity. The rapid rate at which pathogenic microorganisms have developed resistance against frontline antimicrobials has compelled scientists to look for new alternatives. Given their vast antimicrobial repertoire, substantial research effort has been dedicated toward the developme...... hiện toàn bộ Recent Advances in the Development of Indazole‐based Anticancer Agents Tập 13 Số 15 - Trang 1490-1507 - 2018
Jinyun Dong, Qijing Zhang, Zengtao Wang, G. Huang, Shaoshun Li
AbstractCancer is one of the leading causes of human mortality globally; therefore, intensive efforts have been made to seek new active drugs with improved anticancer efficacy. Indazole‐containing derivatives are endowed with a broad range of biological properties, including anti‐inflammatory, antimicrobial, anti‐HIV, antihypertensive, and anticancer activities. In...... hiện toàn bộ Pharmacophore‐Based Discovery of Small‐Molecule Inhibitors of Protein–Protein Interactions between HIV‐1 Integrase and Cellular Cofactor LEDGF/p75 Tập 4 Số 8 - Trang 1311-1316 - 2009
Laura De Luca, Maria Letizia Barreca, Stefania Ferro, Frauke Christ, Nunzio Iraci, Rosaria Gitto, Anna Maria Monforte, Zeger Debyser, Alba Chimirri
AbstractThe cellular protein lens epithelium‐derived growth factor, or transcriptional coactivator p75 (LEDGF/p75), plays a crucial role in HIV integration. The protein–protein interactions (PPIs) between HIV‐1 integrase (IN) and its cellular cofactor LEDGF/p75 may therefore serve as targets for the development of new anti‐HIV drugs. In this work, a st...... hiện toàn bộ From Modeling to Medicinal Chemistry: Automatic Generation of Two‐Dimensional Complex Diagrams Tập 2 Số 6 - Trang 853-860 - 2007
Katrin Stierand, Matthias Rarey
AbstractAs a result of the increasing application of structure‐based drug design, the visualization of protein–ligand complexes has become an important feature in medicinal chemistry. The large number of experimentally resolved complex structures and the further development of computer‐aided methods like docking or de novo design establishes new possibilities in th...... hiện toàn bộ