ChemMedChem
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Conjugated Polymers with Aggregation‐Induced Emission Characteristics for Fluorescence Imaging and Photodynamic Therapy
ChemMedChem - Tập 16 Số 15 - Trang 2330-2338 - 2021
AbstractAccurate diagnosis and treatment have been extensively developed in the
field of biomedicine, which put forward higher requirements for the development
of biomedical materials with high efficiency and selectivity. Among them,
conjugated polymers featuring aggregation‐induced emission (AIE) characteristics
(AIE conjugated polymers) have stood out in recent years owing to their unique
proper...
Design and synthesis of novel β‐carboline‐bisindole hybrids as potential anticancer agents
ChemMedChem -
We are reporting a short and convenient pathway for the synthesis of novel
β‐carboline‐bisindole hybrid compounds from relatively cheap and commercially
available chemicals such as tryptamine, dialdehydes and indoles. These newly
designed compounds can also be prepared in high yields with the tolerance of
many functional groups under mild conditions. Notably, these
β‐carboline‐bisindole hybrid com...
Prodrug Strategies in Anticancer Chemotherapy
ChemMedChem - Tập 3 Số 1 - Trang 20-53 - 2008
AbstractThe majority of clinically approved anticancer drugs are characterized
by a narrow therapeutic window that results mainly from a high systemic toxicity
of the drugs in combination with an evident lack of tumor selectivity. Besides
the development of suitable galenic formulations such as liposomes or micelles,
several promising prodrug approaches have been followed in the last decades with
...
Modelling Inhalational Anaesthetics Using Bayesian Feature Selection and QSAR Modelling Methods
ChemMedChem - Tập 5 Số 8 - Trang 1318-1323 - 2010
AbstractThe development of robust and predictive QSAR models is highly dependent
on the use of molecular descriptors that contain information relevant to the
property being modelled. Selection of these relevant features from a large pool
of possibilities is difficult to achieve effectively. Modern Bayesian methods
provide substantial advantages over conventional feature selection methods for
featu...
Recent Advances in the Development of Indazole‐based Anticancer Agents
ChemMedChem - Tập 13 Số 15 - Trang 1490-1507 - 2018
AbstractCancer is one of the leading causes of human mortality globally;
therefore, intensive efforts have been made to seek new active drugs with
improved anticancer efficacy. Indazole‐containing derivatives are endowed with a
broad range of biological properties, including anti‐inflammatory,
antimicrobial, anti‐HIV, antihypertensive, and anticancer activities. In recent
years, the development of...
How Many Traditional Chinese Medicine Components Have Been Recognized by Modern Western Medicine? A Chemoinformatic Analysis and Implications for Finding Multicomponent Drugs
ChemMedChem - Tập 3 Số 2 - Trang 233-236 - 2008
Structural Studies on 4,5‐Disubstituted 2‐Aminoimidazole‐Based Biofilm Modulators that Suppress Bacterial Resistance to β‐Lactams
ChemMedChem - Tập 7 Số 11 - Trang 2030-2039 - 2012
AbstractA library of 4,5‐disubstituted 2‐aminoimidazole triazole amide (2‐AITA)
conjugates has been successfully assembled. Upon biological screening, this
class of small molecules was discovered as enhanced biofilm regulators through
non‐microbicidal mechanisms against methicillin‐resistant Staphylococcus aureus
(MRSA) and multidrug‐resistant Acinetobacter baumannii (MDRAB), with active
concentra...
Aromatic Core Extension in the Series of N‐Cyclic Bay‐Substituted Perylene G‐Quadruplex Ligands: Increased Telomere Damage, Antitumor Activity, and Strong Selectivity for Neoplastic over Healthy Cells
ChemMedChem - Tập 7 Số 12 - Trang 2144-2154 - 2012
AbstractBased on previous work on both perylene and coronene derivatives as
G‐quadruplex binders, a novel chimeric compound was designed:
N,N′‐bis[2‐(1‐piperidino)‐ethyl]‐1‐(1‐piperidinyl)‐6‐[2‐(1‐piperidino)‐ethyl]‐benzo[ghi]perylene‐3,4:9,10‐tetracarboxylic
diimide (EMICORON), having one piperidinyl group bound to the perylene bay area
(positions 1, 12 and 6, 7 of the aromatic core), sufficient ...
Selective Inhibition of c‐Myc/Max Dimerization by a Pyrazolo[1,5‐a]pyrimidine
ChemMedChem - Tập 2 Số 5 - Trang 627-630 - 2007
Designing Anticancer Peptides by Constructive Machine Learning
ChemMedChem - Tập 13 Số 13 - Trang 1300-1302 - 2018
AbstractConstructive (generative) machine learning enables the automated
generation of novel chemical structures without the need for explicit molecular
design rules. This study presents the experimental application of such a deep
machine learning model to design membranolytic anticancer peptides (ACPs) de
novo. A recurrent neural network with long short‐term memory cells was trained
on α‐helical ...
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