Conjugated Polymers with Aggregation‐Induced Emission Characteristics for Fluorescence Imaging and Photodynamic Therapy

ChemMedChem - Tập 16 Số 15 - Trang 2330-2338 - 2021
Lirong Wang1, Rong Hu1, Anjun Qin1, Ben Zhong Tang2,1
1State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, Center for Aggregation-Induced Emission, South China University of Technology, Guangzhou, 510640, China
2Shenzhen Institute of Aggregate Science and Technology, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 518172, China

Tóm tắt

AbstractAccurate diagnosis and treatment have been extensively developed in the field of biomedicine, which put forward higher requirements for the development of biomedical materials with high efficiency and selectivity. Among them, conjugated polymers featuring aggregation‐induced emission (AIE) characteristics (AIE conjugated polymers) have stood out in recent years owing to their unique properties, such as intense solid emission, high light‐harvesting ability, efficient energy transfer, and high 1O2 generation ability, which empower them with effective biomedical functions in fluorescence imaging (FLI), photodynamic therapy (PDT), FLI‐guided PDT, two‐photon excited photodynamic therapy (2PE‐PDT), etc. In this review, we highlight recent progress in AIE conjugated polymers and their applications in anticancer and antibacterial areas based on FLI and PDT, and summarize the mechanism of color‐tuned fluorescence emission and efficient 1O2 generation ability. The challenges and perspectives for the future development of AIE conjugated polymers are also discussed.

Từ khóa


Tài liệu tham khảo

 

10.1186/s13073-016-0294-z

10.3322/caac.21492

 

10.1021/acs.chemrev.8b00626

10.1002/adma.201801350

10.1039/C6CS00271D

10.1002/agt2.10

10.1002/adfm.202002057

10.1039/D0SC00785D

10.1186/s40824-018-0140-z

 

10.1021/acs.chemrev.5b00244

10.1002/anie.201303387

10.1002/ange.201303387

 

10.1007/s40242-020-0012-7

10.1002/macp.201700440

10.1002/marc.201700614

10.1016/j.chempr.2017.05.002

10.1038/aps.2017.42

10.1021/acs.macromol.6b00958

 

10.1021/acs.accounts.9b00305

10.1002/anie.202000845

10.1002/ange.202000845

10.1039/C9CS00495E

 

10.1002/adma.201806331

10.1002/agt2.7

 

10.1021/acs.accounts.8b00060

10.1002/adfm.202002546

10.1016/j.biomaterials.2021.120725

10.1021/acs.jmedchem.9b02014

10.1021/acsami.9b00643

 

10.1080/10601325.2014.925266

10.1016/j.progpolymsci.2019.101176

10.1016/j.biomaterials.2019.119658

10.1016/j.bioactmat.2020.06.020

10.1007/s11426-019-9517-9

10.1039/C8PY00329G

10.1021/acsami.9b11237

10.1021/acsapm.9b00977

10.1016/j.chempr.2018.07.017

 

10.1002/smll.201801612

10.1002/adfm.201705710

10.1016/j.chempr.2018.06.003

10.1002/anie.201810326

10.1002/ange.201810326

10.1002/adhm.201701248

Gu B., 2017, Adv. Mater., 29

10.1021/acsnano.8b08398

10.1002/anie.201610926

10.1002/ange.201610926

10.1002/anie.201916704

10.1002/ange.201916704

10.1016/j.chempr.2017.10.002

Thông tin
Thông tin xuất bản

ChemMedChem

Tập 16 Số 15

2330-2338

Thông tin tác giả