Topical Delivery of Silver Nanoparticles Promotes Wound Healing

ChemMedChem - Tập 2 Số 1 - Trang 129-136 - 2007
Jun Tian1, Kenneth K. Wong2, Connie Suk‐Han Ho3, Chun‐Nam Lok4, Wing‐Yiu Yu3, Chi‐Ming Che3, Jen‐Fu Chiu4, Paul K. H. Tam2
1Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China.
2Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China, Fax: (+852) 2817-3155
3Department of Chemistry, University of Hong Kong, Hong Kong SAR, China
4Department of Anatomy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China

Tóm tắt

Abstract

Wound healing is a complex process and has been the subject of intense research for a long time. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing remain unknown. We investigated the wound‐healing properties of silver nanoparticles in an animal model and found that rapid healing and improved cosmetic appearance occur in a dose‐dependent manner. Furthermore, through quantitative PCR, immunohistochemistry, and proteomic studies, we showed that silver nanoparticles exert positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenic cytokines. These results have given insight into the actions of silver and have provided a novel therapeutic direction for wound treatment in clinical practice.

Từ khóa


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ChemMedChem

Tập 2 Số 1

129-136

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