Membrane‐Active Small Molecules: Designs Inspired by Antimicrobial Peptides
Tóm tắt
Infectious diseases continue to be one of the major contributors to human morbidity. The rapid rate at which pathogenic microorganisms have developed resistance against frontline antimicrobials has compelled scientists to look for new alternatives. Given their vast antimicrobial repertoire, substantial research effort has been dedicated toward the development of antimicrobial peptides (AMPs) as alternative drugs. However, inherent limitations of AMPs have driven substantial efforts worldwide to develop synthetic mimics of AMPs. This review focuses on the progress that has been made toward the development of small molecules that emulate the properties of AMPs, both in terms of design and biological activity. Herein we provide an extensive discussion of the structural features of various designs and we examine biological properties that have been exploited. Furthermore, we raise a number of questions for which the field has yet to provide solutions and discuss possible future research directions that remain either unexploited or underexploited.
Từ khóa
Tài liệu tham khảo
Antimicrobial Resistance: Global Report on Surveillance 2014 World Health Organization:www.who.int/drugresistance/documents/surveillancereport/en/(accessed August 2015).
Information and Resources on the Government’s Plans to Slow the Growth of Antimicrobial Resistance UK Department of Health Public Health England Department for Environment Food & Rural Affairs and Veterinary Medicines Directorate:www.gov.uk/government/collections/antimicrobial‐resistance‐amr‐information‐and‐resources(accessed August 2015);
National Action Plan for Combating Antibiotic‐Resistant Bacteria March 2015 US Government White House Office of the Press Secretary:www.whitehouse.gov/the‐press‐office/2015/03/27/fact‐sheet‐obama‐administration‐releases‐national‐action‐plan‐combat‐ant(accessed August 2015).
Department of Pathology and Microbiology University of Nebraska Medical Center:aps.unmc.edu/AP/main.php.
Nizet V., 2006, Curr. Issues Mol. Biol., 8, 11
Porter E. A., 2000, Nature, 405, 298
Tew G. N., 2005, Abstr. Pap. Am. Chem. Soc., 229, 982
Hoque J., 2015, J. Med. Chem., 58