Cells

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The Chemically-Modified Tetracycline COL-3 and Its Parent Compound Doxycycline Prevent Microglial Inflammatory Responses by Reducing Glucose-Mediated Oxidative Stress
Cells - Tập 10 Số 8 - Trang 2163
Nilson C. Ferreira‐Junior, Maurício dos Santos Pereira, Nour Francis, Paola Ramírez, Paula Martorell, Florencia González‐Lizárraga, Jean Michel Brunel, Rosana Chehı́n, Elaine Del‐Bel, Rita Raisman‐Vozari, Patrick P. Michel
We used mouse microglial cells in culture activated by lipopolysaccharide (LPS) or α-synuclein amyloid aggregates (αSa) to study the anti-inflammatory effects of COL-3, a tetracycline derivative without antimicrobial activity. Under LPS or αSa stimulation, COL-3 (10, 20 µM) efficiently repressed the induction of the microglial activation marker protein Iba-1 and the stimulated-release of t...... hiện toàn bộ
The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection
Cells - Tập 10 Số 5 - Trang 1130
Antonella D’Amore, Antonella Gradogna, Fioretta Palombi, Velia Minicozzi, Matteo Ceccarelli, Armando Carpaneto, Antonio Filippini
The flavonoid naringenin (Nar), present in citrus fruits and tomatoes, has been identified as a blocker of an emerging class of human intracellular channels, namely the two-pore channel (TPC) family, whose role has been established in several diseases. Indeed, Nar was shown to be effective against neoangiogenesis, a process essential for solid tumor progression, by specifically impairing T...... hiện toàn bộ
Endothelial and Vascular Health: A Tale of Honey, H2O2 and Calcium
Cells - Tập 10 Số 5 - Trang 1071
Elia Ranzato, Gregorio Bonsignore, Mauro Patrone, Simona Martinotti
Intracellular Ca2+ regulation plays a pivotal role in endothelial biology as well as during endothelial restoration processes. Interest in honey utilization in wound approaches is rising in recent years. In order to evaluate the positive effects of buckwheat honey on endothelial responses, we utilized an immortalized endothelial cell line to evaluate cellular responses upon honey exposure,...... hiện toàn bộ
The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis
Cells - Tập 8 Số 10 - Trang 1209
Kara M. de la Harpe, Pierre P. D. Kondiah, Yahya E. Choonara, Thashree Marimuthu, Lisa Du Toit, Viness Pillay
Understanding cell–nanoparticle interactions is critical to developing effective nanosized drug delivery systems. Nanoparticles have already advanced the treatment of several challenging conditions including cancer and human immunodeficiency virus (HIV), yet still hold the potential to improve drug delivery to elusive target sites. Even though most nanoparticles will encounter blood at a c...... hiện toàn bộ
The Role of Bone Morphogenetic Protein 7 (BMP-7) in Inflammation in Heart Diseases
Cells - Tập 9 Số 2 - Trang 280
Chandrakala Aluganti Narasimhulu, Dinender K. Singla
Bone morphogenetic protein-7 is (BMP-7) is a potent anti-inflammatory growth factor belonging to the Transforming Growth Factor Beta (TGF-β) superfamily. It plays an important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. BMP-7 stimulates the target cells by binding to specific membrane-bound receptor BMPR 2 and trans...... hiện toàn bộ
Pathogenic Role of Immune Cells in Rheumatoid Arthritis: Implications in Clinical Treatment and Biomarker Development
Cells - Tập 7 Số 10 - Trang 161
Hooi-Yeen Yap, Sabrina Tee, Magdelyn Wong, S K Chow, Suat‐Cheng Peh, Sin‐Yeang Teow
Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic, inflammatory disorder that affects synovial joints, both small and large joints, in a symmetric pattern. This disorder usually does not directly cause death but significantly reduces the quality of life and life expectancy of patients if left untreated. There is no cure for RA but, patients are usually on long-term disease modif...... hiện toàn bộ
Vaccines against COVID-19: Priority to mRNA-Based Formulations
Cells - Tập 10 Số 10 - Trang 2716
Steve Pascolo
As of September 2021, twenty-one anti-COVID-19 vaccines have been approved in the world. Their utilization will expedite an end to the current pandemic. Besides the usual vaccine formats that include inactivated viruses (eight approved vaccines) and protein-based vaccines (four approved vaccines), three new formats have been validated: recombinant adenovirus (six approved vaccines), DNA (o...... hiện toàn bộ
Proteomic Analysis of Brain Region and Sex-Specific Synaptic Protein Expression in the Adult Mouse Brain
Cells - Tập 9 Số 2 - Trang 313
Ute Distler, Sven Schumann, Hans-Georg Kesseler, Rainer Pielot, Karl‐Heinz Smalla, Malte Sielaff, Michael J. Schmeißer, Stefan Tenzer
Genetic disruption of synaptic proteins results in a whole variety of human neuropsychiatric disorders including intellectual disability, schizophrenia or autism spectrum disorder (ASD). In a wide range of these so-called synaptopathies a sex bias in prevalence and clinical course has been reported. Using an unbiased proteomic approach, we analyzed the proteome at the interaction site of t...... hiện toàn bộ
circRNAs Signature as Potential Diagnostic and Prognostic Biomarker for Diabetes Mellitus and Related Cardiovascular Complications
Cells - Tập 9 Số 3 - Trang 659
Mohamed Zaiou
Circular RNAs (circRNAs) belong to the ever-growing class of naturally occurring noncoding RNAs (ncRNAs) molecules. Unlike linear RNA, circRNAs are covalently closed transcripts mostly generated from precursor-mRNA by a non-canonical event called back-splicing. They are highly stable, evolutionarily conserved, and widely distributed in eukaryotes. Some circRNAs are believed to fulfill a va...... hiện toàn bộ
Metabolomics in Diabetes and Diabetic Complications: Insights from Epidemiological Studies
Cells - Tập 10 Số 11 - Trang 2832
Qiao Jin, Ronald C.W.
The increasing prevalence of diabetes and its complications, such as cardiovascular and kidney disease, remains a huge burden globally. Identification of biomarkers for the screening, diagnosis, and prognosis of diabetes and its complications and better understanding of the molecular pathways involved in the development and progression of diabetes can facilitate individualized prevention a...... hiện toàn bộ
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