Cells
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Emerging Roles of Small GTPases in Islet β-Cell FunctionSeveral small guanosine triphosphatases (GTPases) from the Ras protein superfamily regulate glucose-stimulated insulin secretion in the pancreatic islet β-cell. The Rho family GTPases Cdc42 and Rac1 are primarily involved in relaying key signals in several cellular functions, including vesicle trafficking, plasma membrane homeostasis, and cytoskeletal dynamics. They orchestrate specific ch... ... hiện toàn bộ
Cells - Tập 10 Số 6 - Trang 1503
Hyperglycemia-Induced Aberrant Cell Proliferation; A Metabolic Challenge Mediated by Protein O-GlcNAc ModificationChronic hyperglycemia has been associated with an increased prevalence of pathological conditions including cardiovascular disease, cancer, or various disorders of the immune system. In some cases, these associations may be traced back to a common underlying cause, but more often, hyperglycemia and the disturbance in metabolic balance directly facilitate pathological changes in the regular... ... hiện toàn bộ
Cells - Tập 8 Số 9 - Trang 999
Super-Enhancers Dysregulations in Hematological MalignanciesHematological malignancies affecting either the lymphoid or the myeloid lineages involve epigenetic mutations or dysregulation in the majority of cases. These epigenetic abnormalities can affect regulatory elements in the genome and, particularly, enhancers. Recently, large regulatory elements known as super-enhancers, initially identified for their critical roles in cell-type specific exp... ... hiện toàn bộ
Cells - Tập 11 Số 2 - Trang 196
HSP70 Multi-Functionality in CancerThe 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor immunity, promoting angiogenesis and supporting metastasis. This direct involvement of HSP70 in most of the cancer hallmarks explains the phenome... ... hiện toàn bộ
Cells - Tập 9 Số 3 - Trang 587
Research Advances in Cadmium Uptake, Transport and Resistance in Rice (Oryza sativa L.)Rice (Oryza sativa L.) is one of the most important food crops, feeding half of the world’s population. However, rice production is affected by cadmium (Cd) toxicity. Due to an increase in Cd-contaminated soil and rice grains, and the serious harm to human health from Cd, research on Cd uptake, transport and resistance in rice has been widely conducted, and many important advances have bee... ... hiện toàn bộ
Cells - Tập 11 Số 3 - Trang 569
Regulation of Survivin Isoform Expression by GLI Proteins in Ovarian CancerOvarian cancer (OC) is the most lethal female gynecological malignancy, mostly due to diagnosis in late stages when treatment options are limited. Hedgehog-GLI (HH-GLI) signaling is a major developmental pathway involved in organogenesis and stem cell maintenance, and is activated in OC. One of its targets is survivin (BIRC5), an inhibitor of apoptosis protein (IAP) that plays a role in mu... ... hiện toàn bộ
Cells - Tập 8 Số 2 - Trang 128
Cross-Talk between NADPH Oxidase and Mitochondria: Role in ROS Signaling and AngiogenesisAngiogenesis, a new vessel formation from the pre-existing ones, is essential for embryonic development, wound repair and treatment of ischemic heart and limb diseases. However, dysregulated angiogenesis contributes to various pathologies such as diabetic retinopathy, atherosclerosis and cancer. Reactive oxygen species (ROS) derived from NADPH oxidase (NOX) as well as mitochondria play an ... ... hiện toàn bộ
Cells - Tập 9 Số 8 - Trang 1849
Lắp Ráp và Xâm Nhập của Vi-rút Gây Hội Chứng Hô Hấp Cấp Tính Nặng Loại 2 (SARS-CoV2): Đánh Giá Bằng Các Tiểu Phần Giống Vi-rút Dịch bởi AI Nghiên cứu về vi-rút gây hội chứng hô hấp cấp tính nặng coronavirus 2 (SARS-CoV2) hiện đang bị hạn chế trong các phòng thí nghiệm BSL-3. Các tiểu phần giống vi-rút (VLPs) của SARS-CoV2 cung cấp một hệ thống BSL-1, không có khả năng sao chép, có thể được sử dụng để đánh giá quá trình lắp ráp và xâm nhập của vi-rút vào tế bào trong các điều kiện nuôi cấy tế bào dễ kiểm soát. Tại đây, chúng t... ... hiện toàn bộ
Cells - Tập 10 Số 4 - Trang 853
#SARS-CoV2 #virus-like particles #VLP #virus assembly #virus-cell entry #nanoluciferase #CTD #spike protein #envelope protein #matrix protein #nucleocapsid
Epigenetic Regulation of Skin Cells in Natural Aging and Premature Aging DiseasesSkin undergoes continuous renewal throughout an individual’s lifetime relying on stem cell functionality. However, a decline of the skin regenerative potential occurs with age. The accumulation of senescent cells over time probably reduces tissue regeneration and contributes to skin aging. Keratinocytes and dermal fibroblasts undergo senescence in response to several intrinsic or extrinsic... ... hiện toàn bộ
Cells - Tập 7 Số 12 - Trang 268
Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents TherapyThe mammalian or mechanistic target of rapamycin (mTOR) and associated phosphatidyl-inositiol 3-kinase (PI3K)/protein kinase B (Akt) pathways regulate cell growth, differentiation, migration, and survival, as well as angiogenesis and metabolism. Dysregulation of these pathways is frequently associated with genetic/epigenetic alterations and predicts poor treatment outcomes in a variety of ... ... hiện toàn bộ
Cells - Tập 8 Số 8 - Trang 803
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