Cells

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Forcing the Antitumor Effects of HSPs Using a Modulated Electric Field
Cells - Tập 11 Số 11 - Trang 1838
Carrie Anne Minnaar, Á. Szász
The role of Heat Shock Proteins (HSPs) is a “double-edged sword” with regards to tumors. The location and interactions of HSPs determine their pro- or antitumor activity. The present review includes an overview of the relevant functions of HSPs, which could improve their antitumor activity. Promoting the antitumor processes could assist in the local and systemic management of cancer. We ex...... hiện toàn bộ
Immunogenic Cell Death, DAMPs and Prothymosin α as a Putative Anticancer Immune Response Biomarker
Cells - Tập 11 Số 9 - Trang 1415
Anastasios I. Birmpilis, A. Paschalis, Apostolis Mourkakis, Panayiota Christodoulou, Ioannis V. Kostopoulos, Elina Antimissari, Georgia I. Terzoudi, Alexandros G. Georgakilas, Christina Armpilia, Panagiotis Papageorgis, Efstathios Kastritis, Evangelos Terpos, Meletios Α. Dimopoulos, Hubert Kalbacher, Evangelia Livaniou, Maria Christodoulou, Ourania E. Tsitsilonis
The new and increasingly studied concept of immunogenic cell death (ICD) revealed a previously unknown perspective of the various regulated cell death (RCD) modalities, elucidating their immunogenic properties and rendering obsolete the notion that immune stimulation is solely the outcome of necrosis. A distinct characteristic of ICD is the release of danger-associated molecular patterns (...... hiện toàn bộ
Autophagy: Dual Response in the Development of Hepatocellular Carcinoma
Cells - Tập 8 Số 2 - Trang 91
Hamza O. Yazdani, Hai Huang, Allan Tsung
Autophagy is an evolutionary conserved intracellular mechanism which helps eukaryotic cells in maintaining their metabolic state to afford high-efficiency energy requirements. In the physiology of a normal liver and the pathogenesis of liver diseases, autophagy plays a crucial role. Autophagy has been found to be both upregulated and downregulated in different cancers providing the evidenc...... hiện toàn bộ
Coordination and Crosstalk between Autophagosome and Multivesicular Body Pathways in Plant Stress Responses
Cells - Tập 9 Số 1 - Trang 119
Mengxue Wang, Xifeng Li, Shuwei Luo, Baofang Fan, Cheng Zhu, Zhixiang Chen
In eukaryotic cells, autophagosomes and multivesicular bodies (MVBs) are two closely related partners in the lysosomal/vacuolar protein degradation system. Autophagosomes are double membrane-bound organelles that transport cytoplasmic components, including proteins and organelles for autophagic degradation in the lysosomes/vacuoles. MVBs are single-membrane organelles in the endocytic path...... hiện toàn bộ
Extracellular Metalloproteinases in the Plasticity of Excitatory and Inhibitory Synapses
Cells - Tập 10 Số 8 - Trang 2055
Grzegorz Wiera, Jerzy W. Mozrzymas
Long-term synaptic plasticity is shaped by the controlled reorganization of the synaptic proteome. A key component of this process is local proteolysis performed by the family of extracellular matrix metalloproteinases (MMPs). In recent years, considerable progress was achieved in identifying extracellular proteases involved in neuroplasticity phenomena and their protein substrates. Perisy...... hiện toàn bộ
The Chemically-Modified Tetracycline COL-3 and Its Parent Compound Doxycycline Prevent Microglial Inflammatory Responses by Reducing Glucose-Mediated Oxidative Stress
Cells - Tập 10 Số 8 - Trang 2163
Nilson C. Ferreira‐Junior, Maurício dos Santos Pereira, Nour Francis, Paola Ramírez, Paula Martorell, Florencia González‐Lizárraga, Jean Michel Brunel, Rosana Chehı́n, Elaine Del‐Bel, Rita Raisman‐Vozari, Patrick P. Michel
We used mouse microglial cells in culture activated by lipopolysaccharide (LPS) or α-synuclein amyloid aggregates (αSa) to study the anti-inflammatory effects of COL-3, a tetracycline derivative without antimicrobial activity. Under LPS or αSa stimulation, COL-3 (10, 20 µM) efficiently repressed the induction of the microglial activation marker protein Iba-1 and the stimulated-release of t...... hiện toàn bộ
Apolipoprotein Mimetic Peptides: Potential New Therapies for Cardiovascular Diseases
Cells - Tập 10 Số 3 - Trang 597
Anna Wolska, Mart Reimund, Denis Sviridov, Marcelo Amar, Alan T. Remaley
Since the seminal breakthrough of treating diabetic patients with insulin in the 1920s, there has been great interest in developing other proteins and their peptide mimetics as therapies for a wide variety of other medical disorders. Currently, there are at least 60 different peptides that have been approved for human use and over 150 peptides that are in various stages of clinical develop...... hiện toàn bộ
Systemic Dysfunction of Osteoblast Differentiation in Adipose-Derived Stem Cells from Patients with Multiple Myeloma
Cells - Tập 8 Số 5 - Trang 441
Sylvie Lang, Christelle Mazurier, Martine Auclair, Nathalie Ferrand, Séverine Jolly, Tiffany Marie, Ladan Kobari, Indira Toillon, François Delhommeau, Bruno Fève, Annette K. Larsen, Michèle Sabbah, Laurent Garderet
Multiple myeloma is characterized by bone lesions linked to increased osteoclast and decreased osteoblast activities. In particular, the osteoblast differentiation of bone marrow-derived stem cells (MSC) is impaired. Among the potential therapeutic tools for counteracting bone lesions, adipose-derived stem cells (ASC) could represent an appealing source for regenerative medicine due to the...... hiện toàn bộ
Inhibiting the P2X4 Receptor Suppresses Prostate Cancer Growth In Vitro and In Vivo, Suggesting a Potential Clinical Target
Cells - Tập 9 Số 11 - Trang 2511
Jiepei He, Yuhan Zhou, Hector M. Arredondo Carrera, Alexandria Sprules, Ramona Neagu, Sayyed Amin Zarkesh, Colby L. Eaton, Jian Luo, Alison Gartland, Ning Wang
Prostate cancer (PCa) is the most frequently diagnosed cancer in men, causing considerable morbidity and mortality. The P2X4 receptor (P2X4R) is the most ubiquitously expressed P2X receptor in mammals and is positively associated with tumorigenesis in many cancer types. However, its involvement in PCa progression is less understood. We hypothesized that P2X4R activity enhanced tumour forma...... hiện toàn bộ
The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection
Cells - Tập 10 Số 5 - Trang 1130
Antonella D’Amore, Antonella Gradogna, Fioretta Palombi, Velia Minicozzi, Matteo Ceccarelli, Armando Carpaneto, Antonio Filippini
The flavonoid naringenin (Nar), present in citrus fruits and tomatoes, has been identified as a blocker of an emerging class of human intracellular channels, namely the two-pore channel (TPC) family, whose role has been established in several diseases. Indeed, Nar was shown to be effective against neoangiogenesis, a process essential for solid tumor progression, by specifically impairing T...... hiện toàn bộ
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