Forcing the Antitumor Effects of HSPs Using a Modulated Electric Field
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Kaufmann, 1999, Role of heat shock proteins in protection from and pathogenesis of infectious diseases, Clin. Microbiol. Rev., 12, 19, 10.1128/CMR.12.1.19
Miller, 2018, Heat Shock Proteins Regulatory Role in Neurodevelopment, Front. Neurosci., 12, 821, 10.3389/fnins.2018.00821
Horvath, 2008, Membrane-associated stress proteins: More than simply chaperones, Biochim. Biophys. Acta, 1778, 1653, 10.1016/j.bbamem.2008.02.012
Chen, 2018, Evolution of heat-shock protein expression underlying adaptive responses to environmental stress, Mol. Ecol., 27, 3040, 10.1111/mec.14769
Kaul, 2011, Role of heat shock proteins in diseases and their therapeutic potential, Indian J. Microbiol., 51, 124, 10.1007/s12088-011-0147-9
Sriram, K., Rodriguez-Fernandez, M., and Doyle, F.J. (2021). A detailed modular análisis of heat-shock protein dynamics under acute and chronic stress and its implication in anxiety disorders. PLoS ONE, 7.
Sorger, 2012, Heat shock factor and the heat shock response, Cell, 65, 363, 10.1016/0092-8674(91)90452-5
Asea, A.A.A., and Calderwood, S.K. (2012). Cellular Trafficking of Cell Stress Proteins in Health and Disease, Springer.
Anckar, 2011, Regulation of HSF1 function in the heat stress response: Implications in aging and disease, Annu. Rev. Biochem., 80, 1089, 10.1146/annurev-biochem-060809-095203
Taha, E.A., Ono, K., and Eguchi, T. (2019). Roles of extracellular HSPs as biomarkers in immune surveillance and immune evasion. Int. J. Mol. Sci., 20.
Piacentivi, 2003, Heterochromatin protein 1 (HP1) is associated with induced gene expressio in Drosophila euchromatin, J. Cell Biol., 16, 707, 10.1083/jcb.200303012
Guan, 2021, Upregulation of HSPA1A/HSPA1B/HSPA7 and Downregulation of HSPA9 Were Related to Poor Survival in Colon Cancer, Front. Oncol., 11, 749673, 10.3389/fonc.2021.749673
Watanabe, 1995, Normal human cells at confluence get heat resistance by efficient accumulation of HSP72 in nucleus, Carcinogenesis, 16, 2373, 10.1093/carcin/16.10.2373
Macario, A.J.L., and Conway de Macario, E. (2000). Heat Shock Response, Overview. The Encyclopedia of Stress, Academic Press.
Matarredona, L., Camacho, M., Zafrilla, B., Bonete, M.-J., and Esclapez, J. (2020). The role of stress proteins in haloarchaea and their adaptive response to environmental shifts. Biomolecules, 10.
Calderwood, 2005, Message in a bottle: Role of th 70-kDa heat shock protein family I anti-tumor immuity, Eur. J. Immunol., 35, 2518, 10.1002/eji.200535002
Albakova, 2021, The HSP Immune Network in Cancer, Front. Immunol., 12, 796493, 10.3389/fimmu.2021.796493
Mambula, 2007, Mechanisms for Hsp70 secretion: Crossing membranes without a leader, Methods, 43, 168, 10.1016/j.ymeth.2007.06.009
Kregel, 2002, Heat shock proteins: Modifying factors in physiological stress responses and acquired thermotolerance, J. Appl. Physiol., 92, 2177, 10.1152/japplphysiol.01267.2001
Calderwood, 2007, Extracellular heat shock proteins in cell signaling, FEBS Lett., 581, 3689, 10.1016/j.febslet.2007.04.044
Shevtsov, M., Balogi, Z.s., Khachatryan, W., Gao, H., Vigh, L., and Multhoff, G. (2020). Membrane-associated heat shock proteins in oncology: From basic research to new theranostic targets. Cells, 9.
Tang, 2019, The molecular machinery of regulated cell death, Cell Res., 29, 347, 10.1038/s41422-019-0164-5
Giri, 2017, Heat shock protein 70 in pancreatic diseases: Friend or foe, J. Surg. Oncol., 116, 114, 10.1002/jso.24653
Pockley, 2008, Cell stress proteins in extracellular fluids: Friend or foe?, Novartis Found. Symp., 291, 86, 10.1002/9780470754030.ch7
Wu, 2006, Antibodies against heat shock proteins in environmental stresses and diseases: Friend or foe?, Cell Stress Chaperones, 11, 1, 10.1379/CSC-155R.1
Hance, 2014, The double-edged sword: Conserved functions of extracellular Hsp90 in wound healing and cancer, Cancers, 6, 1065, 10.3390/cancers6021065
Tittelmeier, 2020, Molecular chaperones: A double-sword in neurodegenerative diseases, Front. Aging Neurosci., 12, 581374, 10.3389/fnagi.2020.581374
Trigos, 2018, How the evolution of multicellularity set the stage for cancer, Br. J. Cancer, 118, 145, 10.1038/bjc.2017.398
Popkin, 2011, Physics sheds light on cancer and bacteria evolution, APC News, 20, 5
Aktipis, 2015, Cancer across the tree of life: Cooperation and cheating in multicellularity, Philos. Trans. R. Soc. B Biol. Sci., 370, 20140219, 10.1098/rstb.2014.0219
Davidson, 2019, Cell force-mediated matrix reorganization underlies multicellular network assembly, Sci. Rep., 9, 12, 10.1038/s41598-018-37044-1
Dvorak, 1986, Tumors: Wounds that do not heal, Similarities between tumor stroma generation and wound healing, N. Engl. J. Med., 315, 1650, 10.1056/NEJM198612253152606
Punyiczki, 1998, Heat Shock and Apoptosis: The Two Defense Systems of the Organisms May Have Overlapping Molecular Elements, Ann. N. Y. Acad. Sci., 951, 67, 10.1111/j.1749-6632.1998.tb08978.x
Young, 1990, Stress Proteins and Immunology, Ann. Rev. Immunol., 8, 401, 10.1146/annurev.iy.08.040190.002153
Das, 2019, Heat shock proteins in cancer immunotherapy, J. Oncol., 2019, 3267207, 10.1155/2019/3267207
Fontanetti, 2018, HSP70 as a biomarker: An excellent tool in environmental contamination analysis—A review, Water Air Soil Pollut., 229, 264, 10.1007/s11270-018-3920-0
Siebert, 2019, Heat shock protein 90 as a prognostic marker and therapeutic target for adrenocortical carcinoma, Front. Endocrinol., 10, 487, 10.3389/fendo.2019.00487
Carpenter, 2019, HSF1 as a cancer biomarker and therapeutic target, Curr. Cancer Drug Targets, 19, 515, 10.2174/1568009618666181018162117
Soti, 1998, Molecular Chaperones in the Etiology and Therapy of Cancer, Pathol. Oncol. Res., 4, 316, 10.1007/BF02905225
Soti, 2005, Heat shock proteins as emerging therapeutic targets, Br. J. Pharmacol., 146, 769, 10.1038/sj.bjp.0706396
Xu, 1996, Chronic Thermotolerance with Continued Cell Proliferation, Int. J. Hyperth., 12, 645, 10.3109/02656739609027672
Pirity, 1996, Overexpression of P-glycoprotein in Heta and/or Drug Resistant Hepatoma Variants, Cytotechnology, 19, 207, 10.1007/BF00744214
Santin, 1998, The Effects of Irradiation on the Expression of a Tumor Rejection Antigen (Heat Shock Protein GP96) in Human Cervical Cancer, Int. Radiat. Biol., 76, 699
Morgan, 1998, GRP78 Induction by Calcium Ionophore Potentiates Photodynamic Therapy Using the Mitochondrial Targeting Dye Victoria Blue BO, Photocem. Photobiol., 67, 155
Calderwood, 2017, Molecular chaperone accumulation in cancer and decrease in Alzheimer’s disease: The potential roles of HSF1, Front. Neurosci., 11, 192, 10.3389/fnins.2017.00192
Ciocca, 2005, Heat shock proteins in cancer: Diagnostic, prognostic, predictive, and treatment implications, Cell Stress Chaperones, 10, 86, 10.1379/CSC-99r.1
Rothammer, 2019, Increased heat shock protein 70 (Hsp70) serum levels and low NK cell counts after radiotherapy-potential markers for predicting breast cancer recurrence?, Radiat. Oncol., 14, 78, 10.1186/s13014-019-1286-0
Mosser, 1997, Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis, Mol. Cell. Biol., 17, 5317, 10.1128/MCB.17.9.5317
Vega, 2008, Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages, Immunology, 180, 4299
Gehrmann, 2005, Dual function of membrane-bound heat shock protein (Hsp70), Bag-4, and Hsp40, protection against radiation-induced effects and target structure for natural killer cells, Cell Death Differ., 12, 38, 10.1038/sj.cdd.4401510
Snigireva, 2016, The role of membrane-bound heat shock Hsp90 proteins in the migration of tumor cells in vitro and the involvement of cell surface heparan sulfate proteoglycans in protein binding to the plasma membrane, Biophysics, 61, 277, 10.1134/S0006350916020196
Radons, 2005, Immunostimulatory functions of membrane-bound and exported heat shock protein 70, Exerc. Immunol. Rev., 11, 17
Multhoff, 1997, Heat shock protein 72 on tumor cells: A recognition structure for natural killer cells, J. Immunol., 158, 4341, 10.4049/jimmunol.158.9.4341
Ablakova, 2021, Extracellular heat shock proteins and cancer-New perspectives, Transl. Oncol., 14, 100995, 10.1016/j.tranon.2020.100995
Gas, P. (2017). Essential facts on the history of hyperthermia and their connections with electromedicine. arXiv.
Paulides, 2020, Recent technological advancements in radiofrequency- and microwave-mediated hyperthermia for enhancing drug delivery, Adv. Drug Deliv. Rev., 163–164, 3, 10.1016/j.addr.2020.03.004
Calderwood, 2016, Heat shock proteins promote cancer: It’s a protection racket, Trends Biochem. Sci., 41, 311, 10.1016/j.tibs.2016.01.003
Schilling, 2015, Sensitizing tumor cells to radiation by targeting the heat shock response, Cancer Lett., 360, 294, 10.1016/j.canlet.2015.02.033
Desai, 2013, Heat Shock Factor 1 (HSF1) Controls Chemoresistance and Autophagy through Transcriptioal Regulation of Autophagy-relatd Protein 7 (ATG7), J. Biol. Chem., 288, 9165, 10.1074/jbc.M112.422071
Chatterjee, S., and Burns, T.F. (2017). Targeting Heat Shock Proteins in Cancer-A Promising Therapeutic Approach. Int. J. Mol. Sci., 18.
Yoneda, 2021, Heat shock protein 47 confers chemoresistance on pancreatic cancer cells by interacting with calreticulin and IRE1α, Cancer Sci., 112, 2803, 10.1111/cas.14976
Schwab, M., Thunborg, K., Azmzadeh, O., Von Torne, C., Werner, C., Shevtsov, M., De Genio, T., Zdralevic, M., Pouyssegur, J., and Renner, K. (2021). Targeting Cancer Metabolism Breaks Radioresistance by Impairing the Stress Response. Cancers, 13.
Cheng, 2019, The Role of Hyperthermia in the Multidisciplinary Treatment of Malignant Tumors, Integr. Cancer Ther., 18, 1534735419876345, 10.1177/1534735419876345
Datta, N.R., Jain, B.M., Mathi, Z., Datta, S., Johari, S., Singh, A.R., Kalbande, P., Kale, P., Shivkumar, V., and Bodis, S. (2022). Hyperthermia: A potential game-changer in the management of cancers in low-middl-income group countries. Cancers, 14.
Fiorentini, 2020, A Narrative Review of Regional Hyperthermia-Updates from 2010 to 2019, Integr. Cancer Ther., 19, 1534735420932648, 10.1177/1534735420932648
Datta, 2020, Integrating loco-regional hyperthermia into the current oncology practice: SWOT and TOWS analyses, Front. Oncol., 10, 819, 10.3389/fonc.2020.00819
Hurwitz, 2019, Hyperthermia and immunotherapy: Clinical opportunities, Int. J. Hyperth., 36, 4, 10.1080/02656736.2019.1653499
Roussakow, 2012, The History Of Hyperthermia Rise And Decline, Conf. Pap. Med., 2013, 428027
Lee, 2019, Oncological hyperthermia: The correct dosing in clinical applications, Int. J. Oncol., 54, 627
Cherukuri, 2010, Targeted hyperthermia using metal nanoparticles, Adv. Drug Deliv. Rev., 62, 339, 10.1016/j.addr.2009.11.006
Sohail, 2017, A Review on hypertermia via nanoparticle-mediated therapy, Bull. Cancer, 104, 452, 10.1016/j.bulcan.2017.02.003
Nicolau, 2006, Identifying Optimal Lipid Raft Characteristics Required to Promote Nanoscale Protein-Protein Interactions on the Plasma Membrane, J. Mol. Cell Biol., 26, 313, 10.1128/MCB.26.1.313-323.2006
Yang, 2016, In vitro comparison of conventional hyperthermia and modulated electro-hyperthermia, Oncotarget, 7, 84082, 10.18632/oncotarget.11444
Wust, 2020, Non-thermal effects of radiofrequency electromagnetic fields, Sci. Rep., 10, 13488, 10.1038/s41598-020-69561-3
Wust, 2021, Non-thermal membrane effects of electromagnetic fields and therapeutic applications in oncology, Int. J. Hyperth., 38, 715, 10.1080/02656736.2021.1914354
Frolich, 1982, What are non-thermal electric biological effects?, Bioelectromagnetics, 3, 45, 10.1002/bem.2250030109
Vincze, 2015, Nanoheating without Artificial Nanoparticles, Biol. Med., 7, 249
Sezgin, 2017, The mystery of membrane organization: Composition, regulation and roles of lipid rafts, Nat. Rev. Mol. Cell Biol., 18, 361, 10.1038/nrm.2017.16
Nicolson, 2014, The Fluid—Mosaic Model of Membrane Structure: Still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years, Biochim. Biophys. Acta, 1838, 1451, 10.1016/j.bbamem.2013.10.019
Staunton, 2008, The Physical Sciences-Oncology Centers Network; A physical sciences network characterization of non-tumorigenic and metastatic cells, Sci. Rep., 3, 1449
Cha, 2015, Electro-hyperthermia inhibits glioma tumorigenicity through the induction of E2F1-mediated apoptosis, Int. J. Hyperth., 31, 784, 10.3109/02656736.2015.1069411
Blank, M. (2021, October 21). Evidence for Stress Response (Stress Proteins), Health Risk of Electromagnetic Fields: Research on the Stress Response. Available online: https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.534.8023&rep=rep1&type=pdf.
Blank, 2009, Electromagnetic fields stress living cells, Pathophysiology, 16T, 71, 10.1016/j.pathophys.2009.01.006
Schwan, 1982, Nonthermal Cellular Effects of Electromagnetic Fields: AC-Field Induced Ponderomotoric Forces, Br. J. Cancer, 45, 220
Szasz, 2021, Therapeutic basis of electromagnetic resonances and signal-modulation, Open J. Biophys., 11, 314, 10.4236/ojbiphy.2021.113011
Huilgol, N. (2013). Local Hyperthermia in Oncology–To Choose or Not to Choose?. Hyperthermia, InTech. Chapter 1.
Blank, M. (1999, January 12–14). Coupling of AC Electric Fields to Cellular Processes. Proceedings of the First International Symposium on Nonthermal Medical/Biological Treatments Using Electromagnetic Fields and Ionized Gases, ElectroMed’99, Symposium Record Abstracts, Norfolk, VA, USA.
Zeni, 2017, Cellular response to ELF-MF and heat: Evidence for a common involvement of heat shock proteins?, Front. Public Health, 5, 280, 10.3389/fpubh.2017.00280
Szasz, A. (2020). Challenges Associated with Hyperthermia. Challenges and Solutions of Oncological Hyperthermia, Cambridge Scholars. Chapter 1.
Szasz, 2021, Approaching complexity: Hyperthermia dose and its possible measurement in oncology, Open J. Biophys., 11, 68, 10.4236/ojbiphy.2021.111002
Lee, 2017, Treatment outcome analysis of chemotherapy combined with modulated electro-hyperthermia compared with chemotherapy alone for recurrent cervical cancer, following irradiation, Oncol. Lett., 14, 73, 10.3892/ol.2017.6117
Minnaar, C., Kotzen, J.A., and Baeyens, A. (2021, January 27–31). Modulated Electro-Hyperthermia Improves Three Year Survival in Cervical Cancer Patients, Presentation number: PH-0551. Proceedings of the ESTRO Conference, Madrid, Spain.
Minnaar, C.A., Kotzen, J.A., Ayeni, O.A., Naidoo, T., Tunmer, M., Sharma, V., Vangu, M.-D.-V., and Bayes, A. (2019). The effect of modulated electro-hyperthermia on local disease control in HIV-positive and -negative cervical cancer women in South Africa: Early results from a phase III randomized controlled trial. PLoS ONE, 14.
Lee, 2018, The effect of modulated electro-hyperthermia on temperature and blood flow in human cervical carcinoma, Int. J. Hyperth., 34, 953, 10.1080/02656736.2018.1423709
Minnaar, 2020, Analysis of the effects of mEHT on the treatment- related toxicity and quality of life of HIV-positive cervical cancer patients, Int. J. Hyperth., 37, 263, 10.1080/02656736.2020.1737253
Papp, 2017, Energy absorption by the membrane rafts in the modulated electro-hyperthermia (mEHT), Open J. Biophys., 7, 216, 10.4236/ojbiphy.2017.74016
Szasz, 2021, The capacitive coupling modalities for oncological hyperthermia, Open J. Biophys., 11, 252, 10.4236/ojbiphy.2021.113010
Szasz, O., Szasz, A., and Iluri, N. (2018). RF Hyperthermia Device for Personalized Treatment and Diagnosis. (9,937,357 B2), U.S. Patent.
Andocs, 2014, Upregulation of heat shock proteins and the promotion of damage-associated molecular pattern signals in a colorectal cancer model by modulated electrohyperthermia, Cell Stress Chaperones, 20, 37, 10.1007/s12192-014-0523-6
Meggyeshazi, N., Andocs, G., Spisak, S., and Krenacs, T. (2012, January 12–14). Early Changes in mRNA and Protein Expression Related to Cancer Treatment by Modulated Electro-Hyperthermia. Proceedings of the International Clinical Hyperthermia Society, Budapest, Hungary.
Meggyeshazi, N. (2015). Studies on Modulated Electrohyperthermia Induced Tumor Cell Death in a Colorectal Carcinoma Model. [Ph.D. Thesis, Semmelweis University].
Schvarcz, C.A., Danics, L., Krenacs, T., Viana, P., Beres, R., Vancsik, T., Nagy, A., Gyenesei, A., Kun, J., and Fonovic, M. (2021). Modulated electro-hyperthermia induces a prominent local stress response and growth inhibition in mouse breast cancer isografts. Cancers, 13.
Andocs, 2016, Comparison of biological effects of modulated electro-hyperthermia and conventional heat treatment in human lymphoma U937 cell, Cell Death Discov., 2, 16039, 10.1038/cddiscovery.2016.39
Danics, L., Schvarcz, C.A., Viana, P., Vancsik, T., Krenacs, T., Benyo, Z., Kaucsar, T., and Hamar, P. (2020). Exhaustion of protective heat shock response induces significant tumor damage by apoptosis after modulated electro-hyperthermia treatment of triple negative breast cancer isografts in mice. Cancers, 12.
Besztercei, B., Vancsik, T., Benedek, A., Marjor, E., Thomas, M.J., Schvarcz, C.A., Krenacs, T., Benyo, Z., and Balogh, A. (2019). Stress-induced, p53-mediated tumor growth inhibition of melanoma by modulated electrohyperthermia in mouse models without major immunogenic effects. Int. J. Mol. Sci., 20.
Vancsik, 2018, Modulated electro-hyperthermia induced loco-regional and systemic tumor destruction in colorectal cancer allografts, J. Cancer, 9, 41, 10.7150/jca.21520
Qin, 2014, Modulated electro-hyperthermia enhances dendritic cell therapy through an abscopal effect in mice, Oncol. Rep., 32, 2373, 10.3892/or.2014.3500
Meggyeshazi, 2013, Programmed Cell Death Induced by Modulated Electro-Hyperthermia, Proceedings of the International Clinical Hyperthermia Society 2012, Volume 2013, 187835
Andocs, 2014, DNA fragmentation and caspase-independent programmed cell death by modulated electrohyperthermia, Strahlenther. Onkol., 190, 815, 10.1007/s00066-014-0617-1
Sevrioukova, 2011, Apoptosis-inducing factor: Structure, function, and redox regulation, Antioxid. Redox Signal., 14, 2545, 10.1089/ars.2010.3445
Tsang, Y.-W., Huang, C.-C., Yang, K.-L., Chi, M.-S., Chiang, H.-C., Wang, Y.-S., Andocs, G., Szasz, A., Li, W.-T., and Chi, K.-H. (2015). Improving immunological tumor microenvironment using electro-hyperthermia followed by dendritic cell immunotherapy. BMC Cancer, 15.
Wust, 2019, Physical analysis of temperature-dependent effects of amplitude-modulated electromagnetic hyperthermia, Int. J. Hyperth., 36, 1246, 10.1080/02656736.2019.1692376
Vancsik, 2021, Modulated electro-hyperthermia facilitates NK-cell infiltration and growth arrest of human A2058 melanoma in a xenograft model, Front. Oncol., 11, 164, 10.3389/fonc.2021.590764
Multhoff, 2002, Activation of natural killer cells by heat shock protein 70, Int. J. Hyperth., 18, 576, 10.1080/0265673021000017109
Yilmaz, 2019, Abscopal Effect, From Myth to Reality: From Radiation Oncologists’ Perspective, Cureus, 11, e3860
Wahl, 2009, From RECIST to PERCIST: Evolving Considerations for PET Response Criteria in Solid Tumors, J. Nucl. Med., 50, 122, 10.2967/jnumed.108.057307
Brix, 2017, Abscopal, immunological effects of radiotherapy: Narrowing the gap between clinical and preclinical experiences, Immunol. Rev., 280, 249, 10.1111/imr.12573
Tubin, 2012, A Case Report on Metastatic Thyroid Carcinoma: Radiation-induced Bystander or Abscopal Effect ?, J. Cancer Sci. Ther., 4, 408, 10.4172/1948-5956.1000175
Hlavata, 2018, The Abscopal Effect in the Era of Cancer Immunotherapy: A Spontaneous Synergism Boosting Anti-tumor Immunity?, Target. Oncol., 13, 113, 10.1007/s11523-018-0556-3
Reynders, 2015, The abscopal effect of local radiotherapy: Using immunotherapy to make a rare event clinically relevant, Cancer Treat. Rev., 41, 503, 10.1016/j.ctrv.2015.03.011
Kao, 2020, Relationship between energy dosage and apoptotic cell death by modulated electro-hyperthermia, Sci. Rep., 10, 8936, 10.1038/s41598-020-65823-2
Krenacs, 2017, Tumor specific stress and immune response induced by modulated electrohyperthermia in relation to tumor metabolic profiles, Oncothermia J., 20, 264
Yoon, 2012, Case of Abscopal effect with Metastatic Non-Small-Cell Lung Cancer, Oncothermia J., 5, 53
Fiorentini, 2013, Abscopal effect: New perspectives in Oncothermia, Oncothermia J., 7, 279
Chi, 2021, Marked local and distant response of heavily treated breast cancer with cardiac metastases treated by combined low dose radiotherapy, low dose immunotherapy and hyperthermia: A case report, Ther. Radiol. Oncol., 5, 17, 10.21037/tro-21-16
Schirrmacher, 2015, Long-term survival of a breast cancer patient with extensive liver metastases upon immune and virotherapy: A case report, Immunotherapy, 7, 855, 10.2217/imt.15.48
Chi, 2020, Putative abscopal effect in three patients treated by combined radiotherapy and modulated electrohyperthermia, Front. Oncol., 10, 254, 10.3389/fonc.2020.00254
Szasz, A. (2020). Tumour-Directed Immunotherapy: Clinical Results of Radiotherapy with Modulated Electro-Hyperthermia. Challenges and Solutions of Oncological Hyperthermia, Cambridge Scholars. Chapter 12.
Chi, 2018, Tumor-directed immunotherapy: Combined radiotherapy and oncothermia, Oncothermia J., 24, 196
Pang, 2016, The Immune Regulating Effect of Hyperthermia in Combination with TCM on Cancer Patients, Oncothermia J., 18, 170
Van Gool, S.W., Makalowski, J., Bonner, E.R., Feyen, O., Domogalla, M.P., Prix, L., Schirrmacher, V., Nazarian, J., and Stuecker, W. (2020). Addition of multimodal immunotherapy to combination treatment strategies for children with DIPG: A single institution experience. Medicines, 7.
Van Gool, S.W., Makalowski, J., Fiore, S., Sprenger, T., Prix, L., Schirrmacher, V., and Stuecker, W. (2021). Randomized controlled immunotherapy clinical trials for GBM challenged. Cancers, 13.
Makalowski, 2018, The induction of immunogenic cell death (ICD) during maintenance chemotherapy and subsequent multimodal immunotherapy for glioblastoma (GBM), Austin Oncol. Case Rep., 3, 1
Van Gool, S.W., Makalowski, J., and Stuecker, W. (2018). Modulated electrohyperthermia (mEHT) as part of multimodal immunotherapy for brain tumors. Oncothermia J., 248.
Makalowski, 2019, Hyperthermia as part of multimodal immunotherapy for patients with GBM, Oncothermia J., 27, 122
Makalowski, 2019, Multimodal immunotherapy for patients with ovarian cancer, Oncothermia J., 27, 138
Minnaar, 2020, Potentiation of the Abscopal Effect by Modulated Electro-Hyperthermia in Locally Advanced Cervical Cancer Patients, Front. Oncol., 10, 376, 10.3389/fonc.2020.00376
Blad, 1999, An electrical impedance index to distinguish between normal and cancerous tissues, J. Med. Eng. Technol., 23, 57, 10.1080/030919099294294
Zhou, 2019, Immunogenic cell death in cancer therapy: Present and emerging inducers, J. Cell. Mol. Med., 23, 4854, 10.1111/jcmm.14356
Tadamichi, S., and Takashi, K. (2013). Electromagnetic Effects in Nanoscale Range. Cellular Response to Physical Stress and Therapeutic Applications, Nova Science Publishers, Inc.. Chapter 4.
Andocs, 2015, Nanoheating without Artificial Nanoparticles Part II. Experimental support of the nanoheating concept of the modulated electro-hyperthermia method, using U937 cell suspension model, Biol. Med., 7, 4, 10.4172/0974-8369.1000247
Szasz, 2019, Thermal and nonthermal effects of radiofrequency on living state and applications as an adjuvant with radiation therapy, J. Radiat. Cancer Res., 10, 1, 10.4103/jrcr.jrcr_25_18
Szasz, 2017, Heating preciosity-trends in modern oncological hyperthermia, Open J. Biophys., 7, 116, 10.4236/ojbiphy.2017.73010
Ronchi, 2004, Effects of broad band magnetic fields on HSP70 expression and ischemia-reperfusion in rat hearts, Life Sci., 75, 1925, 10.1016/j.lfs.2003.12.033
Goodman, 2002, Insights into electromagnetic interaction mechanisms, J. Cell. Physiol., 192, 16, 10.1002/jcp.10098
Sapozhnikov, 1999, Spontaneous apoptosis and expression of cell-surface heat-shock proteins in cultured EL-4 lymphoma cells, Cell Prolif., 32, 363, 10.1111/j.1365-2184.1999.tb01354.x
Hildebrandt, 2002, The cellular and molecular basis of hyperthermia, Crit. Rev. Oncol. Hematol., 43, 33, 10.1016/S1040-8428(01)00179-2
Nishida, 1997, Correlation between cell killing effect and cell membrane potential after heat treatment: Analysis using fluorescent dye and flow cytometry, Int. J. Hyperth., 13, 227, 10.3109/02656739709012385
Gehrmann, 2008, The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells, Cell Stress Chaperones, 13, 1, 10.1007/s12192-007-0006-0
Pfister, 2007, Patient survival by Hsp70 membrane phenotype: Association with different routes of metastasis, Cancer, 110, 926, 10.1002/cncr.22864
Multhoff, 2007, Heat shock protein 70 (Hsp70): Membrane location, export and immunological relevance, Methods, 43, 229, 10.1016/j.ymeth.2007.06.006
Andreev, V.P. (2013). Cytoplasmic electric fields and electroosmosis: Possible solution for the paradoxes of the intracellular transport of biomolecules. PLoS ONE, 8.
Multhoff, 2011, Distinguishing integral and receptor-bound heat shock protein 70 (Hsp70) on the cell surface by Hsp70-specific antibodies, Cell Stress Chaperones, 16, 251, 10.1007/s12192-010-0247-1
Calderwood, 2013, Molecular co-chaperones: Tumor growth and cancer treatment, Scientifica, 2013, 217513, 10.1155/2013/217513
Spisek, 2007, Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: Therapeutic implications, Blood, 109, 4839, 10.1182/blood-2006-10-054221
Multhoff, 1995, A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells, Int. J. Cancer, 61, 272, 10.1002/ijc.2910610222
Gehrmann, 2008, Tumor-Specific Hsp70 Plasma Membrane Localization Is Enabled by the Glycosphingolipid Gb3, PLoS ONE, 2, e1925, 10.1371/journal.pone.0001925
Xanthoudakis, 1999, Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis, EMBO J., 18, 2049, 10.1093/emboj/18.8.2049
Szasz, 2003, An energy analysis of extracellular hyperthermia, Electromagn. Biol. Med., 22, 103, 10.1081/JBC-120024620
Jeon, 2016, Electro-hyperthermia up-regulates tumor suppressor Septin 4 to induce apoptotic cell death in hepatocellular carcinoma, Int. J. Hyperth., 32, 648, 10.1080/02656736.2016.1186290
Hou, 2013, Strange attractors: DAMPs and autophagy link tumor cell death and immunity, Cell Death Dis., 4, e966, 10.1038/cddis.2013.493
Garg, 2010, Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation, Biochim. Biophys. Acta, 1805, 53
Lin, 2018, Nano-therapeutic cancer immunotherapy using hyperthermia-induced heat shock proteins: Insights from mathematical modeling, Int. J. Nanomed., 13, 3529, 10.2147/IJN.S166000
Ito, 2005, Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles: A novel concept of “heat-controlled necrosis” with heat shock protein expression, Cancer Immunol. Immunother., 55, 320, 10.1007/s00262-005-0049-y
Ablakova, Z., Armeev, G.A., Kanevskiy, L.M., Kovalenko, E.I., and Sapozhikov, A.M. (2020). HSP70 multi-funtionality in cancer. Cells, 9.
Stocki, 2012, The immunosuppressive activity of heat shock protein 70, Autoimmune Dis., 2012, 617213
Beachy, 2011, Toward establishment of temperature thresholds for immunological impact of heat exposure in humans, Int. J. Hyperth., 27, 344, 10.3109/02656736.2011.562873
Vakkila, 2004, Inflammation and necrosis promote tumour growth, Nat. Rev. Immunol., 4, 641, 10.1038/nri1415
Feyerabend, 2001, Local hyperthermia, radiation, and chemotherapy in recurrent breast cancer is feasible and effective except for inflammatory disease, Int. J. Radiat. Oncol. Biol. Phys., 49, 1317, 10.1016/S0360-3016(00)01514-5
Kumar, 2009, Autologous Hsp70 induces antigen specific Th1 immune responses in a murine T-cell lymphoma, Immunol. Investig., 38, 449, 10.1080/08820130902802673
Jolesch, 2011, Hsp70, a messenger from hyperthermia for the immune system, Eur. J. Cell Biol., 91, 48, 10.1016/j.ejcb.2011.02.001
Hildbrand, 2004, The immune response under stress: The role of HSP-derived peptides, Trends Immunol., 25, 427, 10.1016/j.it.2004.05.011
Binder, 2014, Functions of heat shock proteins in pathways of the innate and adaptive immune system, J. Immunol., 193, 5765, 10.4049/jimmunol.1401417
Krysko, 2018, Macrophages regulate the clearance of living cells by calreticulin, Nat. Commun., 9, 4644, 10.1038/s41467-018-06807-9
Obeid, 2007, Calreticulin exposure dictates the immunogenicity of cancer cell death, Nat. Med., 13, 54, 10.1038/nm1523
Xu, 2019, Role of plasma calreticulin in the prediction of severity in septic patients, Dis. Markers, 2019, 8792640, 10.1155/2019/8792640
Gold, 2009, Calreticulin: Non-endoplamic reticulum functions in physiology and disease, FASEB J., 24, 665, 10.1096/fj.09-145482
Kwon, 2000, Calreticulin couples calcium release and calcium influx in integrin-mediatd calcium signaling, Mol. Biol. Cell, 11, 1433, 10.1091/mbc.11.4.1433
Kazama, 2008, Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group Box-1 protein, Immunity, 29, 21, 10.1016/j.immuni.2008.05.013
Li, 2018, PINK1 and PARK2 suppress pancreatic tumorigenesis through control of mitochondrial iron-mediated immunometabolism, Dev. Cell., 46, 441, 10.1016/j.devcel.2018.07.012
Galluzzi, 2017, Immunogenic cell death in cancer and infectious disease, Nat. Rev. Immunol., 17, 97, 10.1038/nri.2016.107
Medina, 2016, Do not let death do us part-‘find-me’ signals in communication between dying cells and the phygocytes, Cell Death Differ., 23, 979, 10.1038/cdd.2016.13
Michaud, 2011, Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice, Science, 334, 1573, 10.1126/science.1208347
Land, 2015, The role of damage-associated molecular patterns (DAMPs) in human diseases, Sultan Qaboos Univ. Med. J., 15, e157
Hernandez, 2016, Damage-associated molecular patterns in cancer: A double-edged sword, Oncogene, 35, 5931, 10.1038/onc.2016.104
Sangiuliano, 2014, Cell death-associated molecular-pattern molecules: Inflammatory signaling and control, Mediat. Inflamm., 2014, 821043, 10.1155/2014/821043
Hegyi, 2012, On the Dynamic Equilibrium in Homeostasis, Open J. Biophys., 2, 64, 10.4236/ojbiphy.2012.23009
Szigeti, 2020, The growth of healthy and cancerous tissues, Open J. Biophys., 10, 113, 10.4236/ojbiphy.2020.103010
Levin, 2007, Large-scale biophysics: Ion flows and regeneration, Trends Cell Biol., 17, 261, 10.1016/j.tcb.2007.04.007
Szasz, 2018, Role of electrical forces in angiogenesis, Open J. Biophys., 8, 49, 10.4236/ojbiphy.2018.82005
Derer, 2015, Radio-immunotherapy-induced immunogenic cancer cells as basis for induction of systemic anti-tumor immune responses–pre-clinical evidence and ongoing clinical applications, Front. Immunol., 6, 505, 10.3389/fimmu.2015.00505
Stagg, A.J., and Knight, S.C. (2001). Antigen-presenting cells. Nature, 1–8. Available online: http://labs.icb.ufmg.br/lbcd/pages2/bernardo/Bernardo/Artigos/Antigen-presenting%20Cells.pdf.
Kepp, 2011, Molecular determinants of immunogenic cell death elicited by anticancer chemotherapy, Cancer Metastasis Rev., 30, 61, 10.1007/s10555-011-9273-4
Sachamitr, 2012, Cross presentation of antigen by dendritic cells: Mechanisms and implications for immunotherapy, Expert. Rev. Clin. Immunol., 8, 547, 10.1586/eci.12.45
Chi, K.-W. (2018, January 28–29). Tumor-Directed Immunotherapy: Combined Radiotherapy and Oncothermia. Proceedings of the 36th Conference of the International Clinical Hyperthermia Society, Budapest, Hungary.
Holtmeier, 2005, γδ T-cells link innate and adaptive immune responses, Chem. Immunol. Allergy, 86, 151, 10.1159/000086659
Andocs, G., Szasz, A., Szasz, I., and Szasz, N. (2020). Tumor. (U.S. 2015/0217099), Vaccination Patent, Available online: http://www.freepatentsonline.com/20150217099.pdf.