Cells
SCOPUS (2011-2023)SCIE-ISI
2073-4409
Thụy Sĩ
Cơ quản chủ quản: MDPI , Multidisciplinary Digital Publishing Institute (MDPI)
Lĩnh vực:
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Các bài báo tiêu biểu
Mesenchymal Stem Cells for Regenerative MedicineIn recent decades, the biomedical applications of mesenchymal stem cells (MSCs) have attracted increasing attention. MSCs are easily extracted from the bone marrow, fat, and synovium, and differentiate into various cell lineages according to the requirements of specific biomedical applications. As MSCs do not express significant histocompatibility complexes and immune stimulating molecules... ... hiện toàn bộ
Tập 8 Số 8 - Trang 886
Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of ExosomesExosomes are extracellular vesicles that contain a specific composition of proteins, lipids, RNA, and DNA. They are derived from endocytic membranes and can transfer signals to recipient cells, thus mediating a novel mechanism of cell-to-cell communication. They are also thought to be involved in cellular waste disposal. Exosomes play significant roles in various biological functions, incl... ... hiện toàn bộ
Tập 8 Số 4 - Trang 307
Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer—How We Can Rise to the ChallengeTriple-negative (TNBC) is the most lethal subtype of breast cancer owing to high heterogeneity, aggressive nature, and lack of treatment options. Chemotherapy remains the standard of care for TNBC treatment, but unfortunately, patients frequently develop resistance. Accordingly, in recent years, tremendous effort has been made into elucidating the mechanisms of TNBC chemoresistance with th... ... hiện toàn bộ
Tập 8 Số 9 - Trang 957
TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and current treatment is mainly the removal of the causative factor. Transforming growth factor (TGF)-β is a master profibrogenic cytokine and a promising target to treat fibrosis. However, TGF-β has broad biologic... ... hiện toàn bộ
Tập 8 Số 11 - Trang 1419
Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic ApproachesNuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various biological processes, including immune response, inflammation, cell growth and survival, and development. NF-κB is critical for human health, and aberrant NF-κB activation contributes to development of various autoimmune, inflammatory and malignant disorders including rheumatoid arthritis, atherosclero... ... hiện toàn bộ
Tập 5 Số 2 - Trang 15
Pathogenic Role of Immune Cells in Rheumatoid Arthritis: Implications in Clinical Treatment and Biomarker DevelopmentRheumatoid arthritis (RA) is a chronic, autoimmune, systemic, inflammatory disorder that affects synovial joints, both small and large joints, in a symmetric pattern. This disorder usually does not directly cause death but significantly reduces the quality of life and life expectancy of patients if left untreated. There is no cure for RA but, patients are usually on long-term disease modif... ... hiện toàn bộ
Tập 7 Số 10 - Trang 161
Targeting and Crossing the Blood-Brain Barrier with Extracellular VesiclesThe blood–brain barrier (BBB) is one of the most complex and selective barriers in the human organism. Its role is to protect the brain and preserve the homeostasis of the central nervous system (CNS). The central elements of this physical and physiological barrier are the endothelial cells that form a monolayer of tightly joined cells covering the brain capillaries. However, as endothelia... ... hiện toàn bộ
Tập 9 Số 4 - Trang 851
Myeloid-Derived Suppressor Cells as a Therapeutic Target for CancerThe emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have shown remarkable therapeutic outcomes. However, response rates from immunotherapy have been reported to be varied, with some having pronounced success and others with minimal to no clinical benefit. An important aspect associa... ... hiện toàn bộ
Tập 9 Số 3 - Trang 561
Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and DiseasesMitochondrial uncoupling can be defined as a dissociation between mitochondrial membrane potential generation and its use for mitochondria-dependent ATP synthesis. Although this process was originally considered a mitochondrial dysfunction, the identification of UCP-1 as an endogenous physiological uncoupling protein suggests that the process could be involved in many other biological proc... ... hiện toàn bộ
Tập 8 Số 8 - Trang 795
Tangential Flow Filtration for Highly Efficient Concentration of Extracellular Vesicles from Large Volumes of FluidConcentration of extracellular vesicles (EVs) from biological fluids in a scalable and reproducible manner represents a major challenge. This study reports the use of tangential flow filtration (TFF) for the highly efficient isolation of EVs from large volumes of samples. When compared to ultracentrifugation (UC), which is the most widely used method to concentrate EVs, TFF is a more effic... ... hiện toàn bộ
Tập 7 Số 12 - Trang 273