DNA-methylation-mediated silencing of miR-486-5p promotes colorectal cancer proliferation and migration through activation of PLAGL2/IGF2/β-catenin signal pathwaysCell Death and Disease - Tập 9 Số 10
Xiangxiang Liu, Xiaoxiang Chen, Ke Zeng, Mu Xu, Bangshun He, Yuqin Pan, Huiling Sun, Bei Pan, Xueni Xu, Tao Xu, Xiuxiu Hu, Shukui Wang
AbstractAs one of the most common cancers worldwide, colorectal cancer (CRC) causes a large number of mortality annually. Aberrant expression of microRNAs (miRNAs) is significantly associated with the initiation and development of CRC. Further investigations regarding the regulatory mechanism of miRNAs is warranted. In this study, we discovered that miR-486-5p was ...... hiện toàn bộ
Detection of soluble BAG3 and anti-BAG3 antibodies in patients with chronic heart failureCell Death and Disease - Tập 4 Số 2 - Trang e495-e495
Margot De Marco, Antonia Falco, Anna Basile, Alessandra Rosati, Michela Festa, Morena d’Avenia, Maria Pascale, Fabrizio Dal Piaz, Rita Bisogni, Daniela Barcaroli, Giangennaro Coppola, Federico Piscione, Alberto Gigantino, Rodolfo Citro, Roberta De Rosa, Gennaro Vitulano, Nicola Virtuoso, Fiore Manganelli, Ester Palermo, Francesco Siano, Giuseppe Rosato, Michael Hahne, Claudio Tiberti, Vincenzo De Laurenzi, Maria Caterina Turco
lncRNA MIAT functions as a competing endogenous RNA to upregulate DAPK2 by sponging miR-22-3p in diabetic cardiomyopathyCell Death and Disease - Tập 8 Số 7 - Trang e2929-e2929
Xiang Zhou, Wei Zhang, Mengchao Jin, Jianchang Chen, Weiting Xu, Xiangqing Kong
AbstractWe previously established a rat model of diabetic cardiomyopathy (DCM) and found that the expression of long non-coding RNA myocardial infarction–associated transcript (MIAT) was significantly upregulated. The present study was aimed to determine the pathologic role of MIAT in the development of DCM. MIAT knockdown was found to reduce cardiomyocyte apoptosi...... hiện toàn bộ
Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cellsCell Death and Disease - Tập 8 Số 2 - Trang e2633-e2633
Zhuo Yao, Fuhua Xie, Min Li, Zirui Liang, Wenli Xu, Jianhua Yang, Chang Liu, Hongwangwang Li, Hui Zhou, Liang‐Hu Qu
AbstractThe Warburg effect is an important characteristic of tumor cells, making it an attractive therapeutic target. Current anticancer drug development strategies predominantly focus on inhibitors of the specific molecular effectors involved in tumor cell proliferation. These drugs or natural compounds, many of which target the Warburg effect and the underlying m...... hiện toàn bộ
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in miceCell Death and Disease - Tập 13 Số 2
Libin Ni, Jian Xiao, Di Zhang, Zhenxuan Shao, Chongan Huang, Sheng Wang, Yaosen Wu, Naifeng Tian, Liaojun Sun, Aimin Wu, Yifei Zhou, Xiangyang Wang, Xiaolei Zhang
AbstractThe pathophysiology of spinal cord injury (SCI) involves primary injury and secondary injury. Secondary injury is a major target for SCI therapy, whereas microglia play an important role in secondary injury. The immunoresponsive gene 1 (Irg-1) has been recorded as one of the most significantly upregulated genes in SCI tissues in gene chip data; however, its...... hiện toàn bộ
miR-142-3p regulates autophagy by targeting ATG16L1 in thymic-derived regulatory T cell (tTreg)Cell Death and Disease - Tập 9 Số 3
Yunjie Lu, Ji Gao, Shaopeng Zhang, Jian Gu, Hao Lu, Yongxiang Xia, Qin Zhu, Xiaofeng Qian, Feng Zhang, Chuanyong Zhang, Hongbing Shen, Keli L. Hippen, Bruce R. Blazar, Ling Lü, Xuehao Wang
AbstractThymic-derived regulatory T cell (tTreg) clinical trials show therapeutic promise in the prevention of acute graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation patients. However, strategies are needed to improve tTreg proliferative ability and survival as a means to improve tTreg therapy and reduce the requirement for pro...... hiện toàn bộ
Siêu tăng cường và các mục tiêu điều trị mới trong ung thư đại trực tràng Dịch bởi AI Cell Death and Disease - Tập 13 Số 3
Qian Liu, Lijuan Guo, Zhiyuan Lou, Xueping Xiang, Jimin Shao
Tóm tắtCác yếu tố phiên mã, yếu tố đồng thuận, các bước kiểm soát chromatin và các thiết bị phiên mã tương tác với các yếu tố điều chỉnh phiên mã, bao gồm các promoter, enhancer, và siêu-enhancers (SEs), để điều chỉnh phiên mã của các gen mục tiêu một cách đồng bộ và từ đó kiểm soát hành vi của tế bào. Trong số các thành phần điều chỉnh phiên mã này, SEs thường đón...... hiện toàn bộ