Cell Death and Disease

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DNA-methylation-mediated silencing of miR-486-5p promotes colorectal cancer proliferation and migration through activation of PLAGL2/IGF2/β-catenin signal pathways
Cell Death and Disease - Tập 9 Số 10
Xiangxiang Liu, Xiaoxiang Chen, Ke Zeng, Mu Xu, Bangshun He, Yuqin Pan, Huiling Sun, Bei Pan, Xueni Xu, Tao Xu, Xiuxiu Hu, Shukui Wang
AbstractAs one of the most common cancers worldwide, colorectal cancer (CRC) causes a large number of mortality annually. Aberrant expression of microRNAs (miRNAs) is significantly associated with the initiation and development of CRC. Further investigations regarding the regulatory mechanism of miRNAs is warranted. In this study, we discovered that miR-486-5p was remarkably downregulated in CRC, ... hiện toàn bộ
Immunomodulatory activity of IR700-labelled affibody targeting HER2
Cell Death and Disease - Tập 11 Số 10
Justyna Mączyńska, Chiara Da Pieve, Thomas A. Burley, Florian Raes, Anant Shah, Jolanta Saczko, Kevin J. Harrington, Gabriela Krämer-Marek
AbstractThere is an urgent need to develop therapeutic approaches that can increase the response rate to immuno-oncology agents. Photoimmunotherapy has recently been shown to generate anti-tumour immunological responses by releasing tumour-associated antigens from ablated tumour cell residues, thereby enhancing antigenicity and adjuvanticity. Here, we investigate the feasibility of a novel HER2-ta... hiện toàn bộ
High mobility group box 1 promotes radioresistance in esophageal squamous cell carcinoma cell lines by modulating autophagy
Cell Death and Disease - Tập 10 Số 2
Hongbing Ma, Shuyu Zheng, Xiaozhi Zhang, Tuotuo Gong, Xin Lv, Shenbo Fu, Shuqun Zhang, Xiaoran Yin, Jingcan Hao, Changyou Shan, Shan Huang
AbstractResistance to radiotherapy results in relapse and treatment failure in locally advanced esophageal squamous cell carcinoma (ESCC). High mobility group box 1 (HMGB1) is reported to be associated with the radioresistance in bladder and breast cancer. However, the role of HMGB1 in the radiotherapy response in ESCC has not been fully elucidated. Here, we investigated the role of HMGB1 to radio... hiện toàn bộ
Cancer-associated fibroblasts promote progression and gemcitabine resistance via the SDF-1/SATB-1 pathway in pancreatic cancer
Cell Death and Disease - Tập 9 Số 11
Liuya Wei, Huilin Ye, Guolin Li, Yuanting Lu, Quanbo Zhou, Shangyou Zheng, Qing Lin, Yimin Liu, Zhihua Li, Rufu Chen
AbstractCancer-associated fibroblasts (CAFs), a dominant component of the pancreatic tumor microenvironment, are mainly considered as promotors of malignant progression, but the underlying molecular mechanism remains unclear. Here, we show that SDF-1 secreted by CAFs stimulates malignant progression and gemcitabine resistance in pancreatic cancer, partially owing to paracrine induction of SATB-1 i... hiện toàn bộ
Akt inhibitor SC66 promotes cell sensitivity to cisplatin in chemoresistant ovarian cancer cells through inhibition of COL11A1 expression
Cell Death and Disease - Tập 10 Số 4
Yi‐Hui Wu, Yu-Fang Huang, Chien‐Chin Chen, Cheng-Yang Chou
AbstractWe studied Akt inhibition using SC66 in a NOD-SCID xenograft mouse model and a panel of eight ovarian cancer cell lines. Elevated phospho-Akt levels in cancerous tissue were associated with short progression-free survival and overall survival. Cell sensitivity to SC66 was inversely correlated with phospho-Akt and COL11A1 expression levels, as well as resistance to cisplatin or paclitaxel. ... hiện toàn bộ
Caspase-1: is IL-1 just the tip of the ICEberg?
Cell Death and Disease - Tập 3 Số 7 - Trang e338-e338
Ádám Dénes, Gloria López‐Castejón, David Brough
Overcoming MITF-conferred drug resistance through dual AURKA/MAPK targeting in human melanoma cells
Cell Death and Disease - Tập 7 Số 3 - Trang e2135-e2135
Gaurav Pathria, Bhavuk Garg, Viola Borgdorff, Kanika Garg, Christine Wagner, Giulio Superti‐Furga, M. Goos
AbstractMITF (microphthalmia-associated transcription factor) is a frequently amplified lineage-specific oncogene in human melanoma, whose role in intrinsic drug resistance has not been systematically investigated. Utilizing chemical inhibitors for major signaling pathways/cellular processes, we witness MITF as an elicitor of intrinsic drug resistance. To search kinase(s) targets able to bypass MI... hiện toàn bộ
Detection of soluble BAG3 and anti-BAG3 antibodies in patients with chronic heart failure
Cell Death and Disease - Tập 4 Số 2 - Trang e495-e495
Margot De Marco, Antonia Falco, Anna Basile, Alessandra Rosati, Michela Festa, Morena d’Avenia, Maria Pascale, Fabrizio Dal Piaz, Rita Bisogni, Daniela Barcaroli, Giangennaro Coppola, Federico Piscione, Alberto Gigantino, Rodolfo Citro, Roberta De Rosa, Gennaro Vitulano, Nicola Virtuoso, Fiore Manganelli, Ester Palermo, Francesco Siano, Giuseppe Rosato, Michael Hahne, Claudio Tiberti, Vincenzo De Laurenzi, Maria Caterina Turco
The prosurvival protein BAG3: a new participant in vascular homeostasis
Cell Death and Disease - Tập 7 Số 10 - Trang e2431-e2431
Albino Carrizzo, Antonio Damato, Mariateresa Ambrosio, Antonia Falco, Alessandra Rosati, Mario Capunzo, Michele Madonna, Maria Caterina Turco, James L. Januzzi, Vincenzo De Laurenzi, Carmine Vecchione
AbstractBcl2-associated athanogene 3 (BAG3), is constitutively expressed in a few normal cell types, including myocytes, peripheral nerves and in the brain, and is also expressed in certain tumors. To date, the main studies about the role of BAG3 are focused on its pro-survival effect in tumors through various mechanisms that vary according to cellular type. Recently, elevated concentrations of a ... hiện toàn bộ
Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant transformation of human hepatic cells by accelerating the cell cycle and promoting cell proliferation
Cell Death and Disease - Tập 9 Số 5
Xiangyu Dai, Chao Chen, Qianlei Yang, Junchao Xue, Xiong Chen, Baofei Sun, Fei Luo, Xinlu Liu, Tian Xiao, Hui Xu, Qian Sun, Aihua Zhang, Qizhan Liu
AbstractIntercellular communication between malignant cells and neighboring nonmalignant cells is involved in carcinogenesis. In the progression of carcinogenesis, exosomes are messengers for intercellular communication. Circular RNAs (circRNAs) are noncoding RNAs with functions that include regulation of the cell cycle and proliferation. However, the functions of exosomal circRNAs are not clear. ... hiện toàn bộ
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