Cell Death and Disease

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DNA-methylation-mediated silencing of miR-486-5p promotes colorectal cancer proliferation and migration through activation of PLAGL2/IGF2/β-catenin signal pathways
Cell Death and Disease - Tập 9 Số 10
Xiangxiang Liu, Xiaoxiang Chen, Ke Zeng, Mu Xu, Bangshun He, Yuqin Pan, Huiling Sun, Bei Pan, Xueni Xu, Tao Xu, Xiuxiu Hu, Shukui Wang
AbstractAs one of the most common cancers worldwide, colorectal cancer (CRC) causes a large number of mortality annually. Aberrant expression of microRNAs (miRNAs) is significantly associated with the initiation and development of CRC. Further investigations regarding the regulatory mechanism of miRNAs is warranted. In this study, we discovered that miR-486-5p was ...... hiện toàn bộ
Immunomodulatory activity of IR700-labelled affibody targeting HER2
Cell Death and Disease - Tập 11 Số 10
Justyna Mączyńska, Chiara Da Pieve, Thomas A. Burley, Florian Raes, Anant Shah, Jolanta Saczko, Kevin J. Harrington, Gabriela Krämer-Marek
AbstractThere is an urgent need to develop therapeutic approaches that can increase the response rate to immuno-oncology agents. Photoimmunotherapy has recently been shown to generate anti-tumour immunological responses by releasing tumour-associated antigens from ablated tumour cell residues, thereby enhancing antigenicity and adjuvanticity. Here, we investigate t...... hiện toàn bộ
High mobility group box 1 promotes radioresistance in esophageal squamous cell carcinoma cell lines by modulating autophagy
Cell Death and Disease - Tập 10 Số 2
Hongbing Ma, Shuyu Zheng, Xiaozhi Zhang, Tuotuo Gong, Xin Lv, Shenbo Fu, Shuqun Zhang, Xiaoran Yin, Jingcan Hao, Changyou Shan, Shan Huang
AbstractResistance to radiotherapy results in relapse and treatment failure in locally advanced esophageal squamous cell carcinoma (ESCC). High mobility group box 1 (HMGB1) is reported to be associated with the radioresistance in bladder and breast cancer. However, the role of HMGB1 in the radiotherapy response in ESCC has not been fully elucidated. Here, we invest...... hiện toàn bộ
Cancer-associated fibroblasts promote progression and gemcitabine resistance via the SDF-1/SATB-1 pathway in pancreatic cancer
Cell Death and Disease - Tập 9 Số 11
Liuya Wei, Huilin Ye, Guolin Li, Yuanting Lu, Quanbo Zhou, Shangyou Zheng, Qing Lin, Yimin Liu, Zhihua Li, Rufu Chen
AbstractCancer-associated fibroblasts (CAFs), a dominant component of the pancreatic tumor microenvironment, are mainly considered as promotors of malignant progression, but the underlying molecular mechanism remains unclear. Here, we show that SDF-1 secreted by CAFs stimulates malignant progression and gemcitabine resistance in pancreatic cancer, partially owing t...... hiện toàn bộ
Akt inhibitor SC66 promotes cell sensitivity to cisplatin in chemoresistant ovarian cancer cells through inhibition of COL11A1 expression
Cell Death and Disease - Tập 10 Số 4
Yi‐Hui Wu, Yu-Fang Huang, Chien‐Chin Chen, Cheng-Yang Chou
AbstractWe studied Akt inhibition using SC66 in a NOD-SCID xenograft mouse model and a panel of eight ovarian cancer cell lines. Elevated phospho-Akt levels in cancerous tissue were associated with short progression-free survival and overall survival. Cell sensitivity to SC66 was inversely correlated with phospho-Akt and COL11A1 expression levels, as well as resist...... hiện toàn bộ
Caspase-1: is IL-1 just the tip of the ICEberg?
Cell Death and Disease - Tập 3 Số 7 - Trang e338-e338
Ádám Dénes, Gloria López‐Castejón, David Brough
Detection of soluble BAG3 and anti-BAG3 antibodies in patients with chronic heart failure
Cell Death and Disease - Tập 4 Số 2 - Trang e495-e495
Margot De Marco, Antonia Falco, Anna Basile, Alessandra Rosati, Michela Festa, Morena d’Avenia, Maria Pascale, Fabrizio Dal Piaz, Rita Bisogni, Daniela Barcaroli, Giangennaro Coppola, Federico Piscione, Alberto Gigantino, Rodolfo Citro, Roberta De Rosa, Gennaro Vitulano, Nicola Virtuoso, Fiore Manganelli, Ester Palermo, Francesco Siano, Giuseppe Rosato, Michael Hahne, Claudio Tiberti, Vincenzo De Laurenzi, Maria Caterina Turco
Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling
Cell Death and Disease - Tập 9 Số 2
Xin Zhang, Zhen‐Guo Ma, Yu‐Pei Yuan, Si‐Chi Xu, Wenying Wei, Peng Song, Chun‐Yan Kong, Wei Deng, Qi‐Zhu Tang
AbstractAgonists of peroxisome proliferator-activated receptor gamma (PPAR-γ) can activate 5′ AMP-activated protein kinase alpha (AMPKα) and exert cardioprotective effects. A previous study has demonstrated that rosmarinic acid (RA) can activate PPAR-γ, but its effect on cardiac remodeling remains largely unknown. Our study aimed to investigate the effect of RA on ...... hiện toàn bộ
lncRNA MIAT functions as a competing endogenous RNA to upregulate DAPK2 by sponging miR-22-3p in diabetic cardiomyopathy
Cell Death and Disease - Tập 8 Số 7 - Trang e2929-e2929
Xiang Zhou, Wei Zhang, Mengchao Jin, Jianchang Chen, Weiting Xu, Xiangqing Kong
AbstractWe previously established a rat model of diabetic cardiomyopathy (DCM) and found that the expression of long non-coding RNA myocardial infarction–associated transcript (MIAT) was significantly upregulated. The present study was aimed to determine the pathologic role of MIAT in the development of DCM. MIAT knockdown was found to reduce cardiomyocyte apoptosi...... hiện toàn bộ
Upconversion nanoparticle-mediated photodynamic therapy induces autophagy and cholesterol efflux of macrophage-derived foam cells via ROS generation
Cell Death and Disease - Tập 8 Số 6 - Trang e2864-e2864
Xiaobo Han, Hongxia X Li, Xiufeng Zheng, Hao Wang, Xuesong S Li, Jiayuan Kou, Yinghong Zheng, Zhongni N Liu, Hong Li, Jing Li, Dou Dou, You Wang, Ye Tian, Liming Yang
AbstractMacrophage-derived foam cells are a major component of atherosclerotic plaques and have an important role in the progression of atherosclerotic plaques, thus posing a great threat to human health. Photodynamic therapy (PDT) has emerged as a therapeutic strategy for atherosclerosis. Here, we investigated the effect of PDT mediated by upconversion fluorescent...... hiện toàn bộ
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