Cancer

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Antineoplastic effects of 15(S)‐hydroxyeicosatetraenoic acid and 13‐S‐hydroxyoctadecadienoic acid in non–small cell lung cancer
Cancer - Tập 121 Số S17 - Trang 3130-3145 - 2015
Mingyue Li, Hui-Ling Yuan, Fanny W.S. Ko, Bin Wu, Xiang Long, Jing Du, Jun Wu, Calvin S.H. Ng, Innes Y.P. Wan, Tony Mok, David S.C. Hui, Malcolm J. Underwood, George G. Chen
BACKGROUNDPrevious studies have shown that the levels of 15‐lipoxygenase 1 (15‐LOX‐1) and 15‐LOX‐2 as well as their metabolites 13‐S‐hydroxyoctadecadienoic acid (13(S)‐HODE) and 15(S)‐hydroxyeicosatetraenoic acid (15(S)‐HETE) are significantly reduced in smokers with non–small cell lung carcinoma (NSCLC). Furthermore, animal model experiments have indicat...... hiện toàn bộ
Targeting cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4)
Cancer - Tập 110 Số 12 - Trang 2614-2627 - 2007
Steven O’Day, Omid Hamid, Walter J. Urba
AbstractCancer immunotherapy centers on modulating the host's tumor‐directed immune response. One promising approach involves augmentation of cell‐mediated immunity by interrupting T‐cell pathways responsible for immune down‐regulation or tolerance. The discovery of cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) and its role as a key negative regulator for T cells has p...... hiện toàn bộ
Comparison of the clinicopathologic features and prognosis of bilateral versus unilateral multifocal papillary thyroid cancer: An updated study with more than 2000 consecutive patients
Cancer - Tập 122 Số 2 - Trang 198-206 - 2016
Weibin Wang, Xingyun Su, Kuifeng He, Yanli Wang, Haiyong Wang, Haohao Wang, Yinu Zhao, Wenhe Zhao, Rasa Zarnegar, Thomas J. Fahey, Xiaodong Teng, Lisong Teng
BACKGROUNDBilaterality is common in papillary thyroid cancer (PTC), but its clinical and prognostic implications are still controversial, and it remains unclear whether its behavior is more aggressive than multifocality.METHODSThe clinicopathologic features of 2211 consecutive patients with PT...... hiện toàn bộ
The impact of health insurance on cancer care in disadvantaged communities
Cancer - Tập 123 Số 7 - Trang 1219-1227 - 2017
Zaid M. Abdelsattar, Samantha Hendren, Sandra L. Wong
BACKGROUNDIndividuals from disadvantaged communities are among the millions of uninsured Americans gaining insurance under the Affordable Care Act. The extent to which health insurance can mitigate the effects of the social determinants of health on cancer care is unknown.METHODSThis study lin...... hiện toàn bộ
Stereotactic linear accelerater‐based radiosurgery for the treatment of patients with glomus jugulare tumors
Cancer - Tập 97 Số 4 - Trang 1093-1098 - 2003
Mohammad Maarouf, Jürgen Voges, P. Landwehr, Rainer Bramer, Harald Treuer, Martin Köcher, Rolf‐Peter Müller, Volker Sturm
AbstractBACKGROUNDThe optimal treatment for patients with glomus jugulare tumor (GJT) of the skull base remains controversial. Surgical excision is associated with a high incidence of cranial nerve injury, decreased quality of life, and high mortality. Fractionated radiotherapy is used to control the majority of these tumors, but ...... hiện toàn bộ
Analysis of prognostic factors in ewing sarcoma family of tumors
Cancer - Tập 110 Số 2 - Trang 375-384 - 2007
Carlos Rodríguez‐Galindo, Tiebin Liu, Matthew J. Krasin, Jianrong Wu, Catherine A. Billups, Najat C. Daw, Sheri L. Spunt, Bhaskar N. Rao, Victor M. Santana, Fariba Navid
AbstractBACKGROUND.Advances in systemic and local therapies have improved outcomes for patients with the Ewing sarcoma family of tumors (ESFT). As new treatments are developed, a critical review of data from past treatment eras is needed to identify clinically relevant risk groups.METHODS....... hiện toàn bộ
The continuing increase in the incidence of primary central nervous system non‐Hodgkin lymphoma
Cancer - Tập 95 Số 7 - Trang 1504-1510 - 2002
Janet E. Olson, Carol A. Janney, Ravi D. Rao, James R. Cerhan, Paul J. Kurtin, David Schiff, Richard Kaplan, Brian Patrick O’Neill
AbstractBACKGROUNDPrimary central nervous system lymphoma (PCNSL) is an extranodal form of non‐Hodgkin lymphoma arising in the craniospinal axis. The incidence of PCNSL appears to be increasing.METHODSPCNSL incidence data from 1973–1997 were obtained from the nine Surv...... hiện toàn bộ
High incidence of ras gene mutation in intrahepatic cholangiocarcinoma
Cancer - Tập 69 Số 5 - Trang 1115-1118 - 1992
Minoru Tada, Masao Omata, Masao Ohio
AbstractThe DNA sequences around codons 12, 13, and 61 of the ras gene were analyzed by polymerase chain reaction and direct sequencing in 18 intrahepatic cholangiocar‐cinomas. The ras gene mutations were found in 9 of 18 (50%): 6 in K‐ras codon 12, 1 in K‐ras... hiện toàn bộ
Obesity and hypertension among children after treatment for acute lymphoblastic leukemia
Cancer - Tập 110 Số 10 - Trang 2313-2320 - 2007
Eric J. Chow, Catherine Pihoker, Kathryn Hunt, Karen Wilkinson, Debra L. Friedman
AbstractBACKGROUND.The purpose was to determine the prevalence and treatment‐related risk factors for obesity and hypertension among childhood acute lymphoblastic leukemia (ALL) survivors treated with contemporary therapy.METHODS.In a single‐center longitudinal study, ...... hiện toàn bộ
The American Cancer Society Cancer Prevention Study II Nutrition Cohort
Cancer - Tập 94 Số 9 - Trang 2490-2501 - 2002
Eugenia E. Calle, Carmen Rodríguez, Eric J. Jacobs, Marie Almon, Ann Chao, Marjorie L. McCullough, Heather Thorne, Michael J. Thun
AbstractBACKGROUNDLarge‐scale, prospective cohort studies have played a critical role in discovering factors that contribute to variability in cancer risk in human populations. Epidemiologists and volunteers at the American Cancer Society (ACS) were among the first to establish such cohorts, beginning in the early 1950s and contin...... hiện toàn bộ
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