Cancer
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Extent of resection and overall survival for patients with atypical and malignant meningiomaBACKGROUND The prognosis for patients with atypical and malignant meningioma is guarded; whether the extent of resection is associated with survival‐based outcomes in this population remains poorly defined. This study investigated the association between gross total resection (GTR) and all‐cause mortality in patients with atypical and malignant meningioma....
Cancer - Tập 121 Số 24 - Trang 4376-4381 - 2015
Is the long‐term survival of patients with intracranial glioblastoma multiforme overstated?Abstract BACKGROUND The 5‐year survival rate for intracranial glioblastoma multiforme (GBM) has remained at 4–5% for the last 30 years, in spite of multiple randomized prospective trials. The authors hypothesized, based on the literature, that even this remarkably poor survival rate is an overstatement. They investigated this hypoth...
Cancer - Tập 98 Số 8 - Trang 1745-1748 - 2003
Quality of life and sexual problems in disease‐free survivors of cervical cancer compared with the general populationAbstract BACKGROUND. The purpose of this study was to identify problems related to long‐term quality of life (QOL) and sexual function in cervical cancer survivors. METHODS. The authors enrolled 860 women (median time since diagnosis, 5.86 years) with a history of cervical...
Cancer - Tập 110 Số 12 - Trang 2716-2725 - 2007
Proteasome inhibition and its clinical prospects in the treatment of hematologic and solid malignanciesAbstract The proteasome is responsible for the degradation of intracellular proteins, including several involved in cell cycle control and the regulation of apoptosis. Preclinical studies have shown that the proteasome inhibitor bortezomib decreases proliferation, induces apoptosis, enhances the activity of chemotherapy and radiation, and reverses chemoresistance in... ... hiện toàn bộ
Cancer - Tập 104 Số 9 - Trang 1794-1807 - 2005
Inotuzumab ozogamicin in combination with low‐intensity chemotherapy (mini‐HCVD) with or without blinatumomab versus standard intensive chemotherapy (HCVAD) as frontline therapy for older patients with Philadelphia chromosome‐negative acute lymphoblastic leukemia: A propensity score analysisBackground The outcome of older patients with newly diagnosed, Philadelphia chromosome (Ph)‐negative acute lymphoblastic leukemia (ALL) is poor. The combination of targeted therapy with low‐intensity chemotherapy is safe and effective. The objective of the current analysis was to compare the outcome of patients who received a combination of inotuzumab ozog...
Cancer - Tập 125 Số 15 - Trang 2579-2586 - 2019
Nodular, lymphocyte‐predominant Hodgkin lymphomaAbstract BACKGROUND: Nodular, lymphocyte‐predominant Hodgkin lymphoma (NLPHL) represents a rare entity. METHODS: A clinical registry was launched from 1973 to 2003 in France. To determine the histologic transformation (HT) rate to diffuse large B‐cell lymphoma (DLBCL) and ...
Cancer - Tập 116 Số 3 - Trang 631-639 - 2010
Fractionated low‐dose radiotherapy after myeloablative stem cell transplantation for local control in patients with high‐risk neuroblastomaAbstract BACKGROUND The optimal administration of radiotherapy for patients with high‐risk neuroblastoma (NB) currently is undefined in the context of modern therapy using myeloablative chemotherapy with autologous stem cell rescue (hematopoietic stem cell transplantation [HSCT]). METHODS... hiện toàn bộ
Cancer - Tập 100 Số 6 - Trang 1268-1275 - 2004
Bovine leukemia virus linked to breast cancer but not coinfection with human papillomavirus: Case‐control study of women in TexasBACKGROUND Bovine leukemia virus (BLV) and human papillomavirus (HPV) were previously identified in human breast tissue and have been associated with breast cancer in independent studies. The objective of the current study was to test for the presence of BLV and HPV in the same breast tissue specimens to determine whether the viruses were associated with b...
Cancer - Tập 124 Số 7 - Trang 1342-1349 - 2018
Comparative effectiveness of three platinum‐doublet chemotherapy regimens in elderly patients with advanced non–small cell lung cancerBACKGROUND Randomized trials report equivalent efficacy among various combinations of platinum‐based regimens in advanced non–small cell lung cancer (NSCLC). Their relative effectiveness and comparability based on squamous versus nonsquamous histology is uncertain. METHODS The authors used the Su...
Cancer - Tập 119 Số 11 - Trang 2048-2060 - 2013
Incidence and relative survival of chordomasBACKGROUND Chordomas are rare bone tumors arising from remnants of the embryonic notochord. METHODS Data for this study were obtained from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute (1973‐2009) to calculate the incidence, relative survival (RS)...
Cancer - Tập 119 Số 11 - Trang 2029-2037 - 2013
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