Cancer
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Outcomes of radical nephroureterectomy: A series from the Upper Tract Urothelial Carcinoma Collaboration
Cancer - Tập 115 Số 6 - Trang 1224-1233 - 2009
AbstractBACKGROUND:The literature on upper tract urothelial carcinoma (UTUC) has
been limited to small, single center studies. A large series of patients treated
with radical nephroureterectomy for UTUC were studied, and variables associated
with poor prognosis were identified.METHODS:Data on 1363 patients treated with
radical nephroureterectomy at 12 academic centers were collected. All pathologi...
Social networks and quality of life among female long‐term colorectal cancer survivors
Cancer - Tập 98 Số 8 - Trang 1749-1758 - 2003
AbstractBACKGROUNDThe population of long‐term colorectal cancer survivors in the
United States continues to increase, but little is known about how they
fare—physically, mentally, or socially—in the years after diagnosis. The current
study examines female long‐term colorectal cancer survivors' health‐related
quality of life (HRQoL) in relation to social networks.METHODSA population‐based
sample of...
Paranasal sinus squamous cell carcinoma incidence and survival based on Surveillance, Epidemiology, and End Results data, 1973 to 2009
Cancer - Tập 119 Số 14 - Trang 2602-2610 - 2013
BACKGROUNDParanasal sinus squamous cell carcinomas (PNSSCC) account for 3% of
all head and neck malignancies. There has been little information on the trends
in incidence and survival, and no randomized trials have been conducted to guide
therapy.METHODSPatients with PNSSCC reported to the Surveillance, Epidemiology,
and End Results (SEER) Program from 1973 through 2009 were categorized by sex,
ag...
Preoperative chemotherapy for sinonasal squamous cell carcinoma (SNSCC): Time to move closer to a definitive answer
Cancer - Tập 127 Số 11 - Trang 1734-1735 - 2021
Although results from this retrospective series suggest that preoperative
chemotherapy may offer a benefit to organ preservation in sinonasal squamous
cell carcinoma, prospective data are needed to confirm these observations.
Clinicopathologic characteristics of pancreatic neuroendocrine tumors and relation of somatostatin receptor type 2A to outcomes
Cancer - Tập 119 Số 23 - Trang 4094-4102 - 2013
BACKGROUNDThe impact of somatostatin receptor type 2 (SSTR‐2a) expression levels
on outcomes in patients with pancreatic neuroendocrine tumors (PNETs) has not
been evaluated.METHODSCorrelations between clinicopathologic characteristics,
including SSTR‐2a expression and outcomes, were retrospectively studied in 79
patients with pancreatic neuroendocrine tumors (PNETs).RESULTSThe SSTR‐2a score
was 0...
Prospective study of the antitumor efficacy of long‐term octreotide treatment in patients with progressive metastatic gastrinoma
Cancer - Tập 94 Số 2 - Trang 331-343 - 2002
AbstractBACKGROUNDMalignant pancreatic endocrine tumors (PETs) have a poor
prognosis and existing antitumor treatments are unsatisfactory. Recent studies
have shown somatostatin analogues to have antitumor growth effects in patients
with malignant PETs; however, to the authors' knowledge, little information
exists regarding their efficacy or effect on survival in patients with
progressive malignan...
Clinical impact and frequency of anatomic pathology errors in cancer diagnoses
Cancer - Tập 104 Số 10 - Trang 2205-2213 - 2005
AbstractBACKGROUNDTo the authors' knowledge, the frequency and clinical impact
of errors in the anatomic pathology diagnosis of cancer have been poorly
characterized to date.METHODSThe authors examined errors in patients who
underwent anatomic pathology tests to determine the presence or absence of
cancer or precancerous lesions in four hospitals. They analyzed 1 year of
retrospective errors detec...
Adenoid cystic carcinoma of the breast
Cancer - Tập 94 Số 8 - Trang 2119-2127 - 2002
AbstractBACKGROUNDThe objective of this study was to comprehensively
characterize the clinical and biologic features of adenoid cystic carcinoma
(ACC) and to assess the implications for management in a large cohort of
patients.METHODSFrom a database of 50,000 patients, 28 were identified with ACC
for which clinical follow‐up and biologic information was available. The
biologic features examined in...
Antineoplastic effects of 15(S )‐hydroxyeicosatetraenoic acid and 13‐S ‐hydroxyoctadecadienoic acid in non–small cell lung cancer
Cancer - Tập 121 Số S17 - Trang 3130-3145 - 2015
BACKGROUNDPrevious studies have shown that the levels of 15‐lipoxygenase 1
(15‐LOX‐1) and 15‐LOX‐2 as well as their metabolites 13‐S‐hydroxyoctadecadienoic
acid (13(S)‐HODE) and 15(S)‐hydroxyeicosatetraenoic acid (15(S)‐HETE) are
significantly reduced in smokers with non–small cell lung carcinoma (NSCLC).
Furthermore, animal model experiments have indicated that the reduction of these
molecules oc...
Targeting cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4)
Cancer - Tập 110 Số 12 - Trang 2614-2627 - 2007
AbstractCancer immunotherapy centers on modulating the host's tumor‐directed
immune response. One promising approach involves augmentation of cell‐mediated
immunity by interrupting T‐cell pathways responsible for immune down‐regulation
or tolerance. The discovery of cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) and its
role as a key negative regulator for T cells has prompted efforts to target this
si...
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