The continuing increase in the incidence of primary central nervous system non‐Hodgkin lymphoma

Cancer - Tập 95 Số 7 - Trang 1504-1510 - 2002
Janet E. Olson1, Carol A. Janney1, Ravi D. Rao2, James R. Cerhan1, Paul J. Kurtin3, David Schiff4, Richard Kaplan5, Brian Patrick O’Neill6,7
1Health Sciences Research, Cancer Epidemiology, Mayo Clinic and Foundation and the Mayo Clinic Cancer Center, Rochester, Minnesota
2Department of Oncology, Mayo Clinic and Foundation and the Mayo Clinic Cancer Center, Rochester, Minnesota
3Department of Pathology, Mayo Clinic and Foundation and the Mayo Clinic Cancer Center, Rochester, Minnesota
4Department of Neurosurgery, University of Pittsburgh Medical Center and the Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
5Clinical Trials Evaluation Program, National Cancer Institute, Rockville, Maryland
6Department of Neurology, Mayo Clinic and Foundation and the Mayo Clinic Cancer Center, Rochester, Minnesota
7Fax: 507-284-4074

Tóm tắt

AbstractBACKGROUNDPrimary central nervous system lymphoma (PCNSL) is an extranodal form of non‐Hodgkin lymphoma arising in the craniospinal axis. The incidence of PCNSL appears to be increasing.METHODSPCNSL incidence data from 1973–1997 were obtained from the nine Surveillance, Epidemiology and End Results (SEER) registries. To limit the influence of the human immunodeficiency virus on incidence rates, data of never–married males and females and persons of unknown marital status were excluded. As a surrogate for new technology, SEER data were reviewed by dates of diagnosis (surrogate for imaging) and compared with glioma incidence (surrogate for stereotactic neurosurgery and improved diagnostic neuropathology). Age‐adjusted incidence rates were estimated and compared for the period prior to computed tomography (CT) (1973–1984) and the magnetic resonance imaging (MRI) period (1985–1997). The estimated annual percent change was calculated based on linear regression analyses using SEER*STAT.RESULTSThe incidence of PCNSL appears to be increasing in all SEER registries examined. All age groups demonstrated an increase over time. This increase was observed both in the CT era as well as in the MRI era. PCNSL age‐adjusted incidence (0.15 to 0.48, a 3‐fold increase) outpaced that of systemic lymphoma (14.1 to 18.5, a 33% increase) for the same registries over the same time periods. The rate of increase has begun to slow since 1985; the estimated annual percent change for PCNSL was three‐fold higher during the period 1973–1985 compared with 1986–1997.CONCLUSIONThe incidence rate of PCNSL continues to rise. The increase is evident in all age groups and in both genders. Data from the current study suggest that improved diagnostic tools, such as CT or MRI, cannot explain this increase. Cancer 2002;95:1504–10. © 2002 American Cancer Society.DOI 10.1002/cncr.10851

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Cancer

Tập 95 Số 7

1504-1510

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