Stereotactic linear accelerater‐based radiosurgery for the treatment of patients with glomus jugulare tumors

Cancer - Tập 97 Số 4 - Trang 1093-1098 - 2003
Mohammad Maarouf1, Jürgen Voges1, P. Landwehr2, Rainer Bramer1, Harald Treuer1, Martin Köcher3, Rolf‐Peter Müller3, Volker Sturm1
1Department of Stereotactic and Functional Neurosurgery, University of Cologne, Cologne, Germany
2Institute of Diagnostic Radiology, University of Cologne, Cologne, Germany
3Department of Radiation Oncology, University of Cologne, Cologne, Germany;

Tóm tắt

AbstractBACKGROUNDThe optimal treatment for patients with glomus jugulare tumor (GJT) of the skull base remains controversial. Surgical excision is associated with a high incidence of cranial nerve injury, decreased quality of life, and high mortality. Fractionated radiotherapy is used to control the majority of these tumors, but disadvantages are a prolonged therapy interval and exposition of adjacent brain tissue to irradiation. The authors present the results of a study on 12 of 14 consecutively admitted patients who were treated using linear accelerator‐based radiosurgery (LINAC‐RS), an innovative method for the treatment of GJT.METHODSFrom May 1991 to March 2001, 14 patients with GJT were treated with stereotactic LINAC‐RS for continued growth of tumor or of remaining tumor after surgery. Twelve patients (9 women and 3 men; age range, 28–71 years; median age, 59 years) with a median follow‐up of 4 years (range, 0.8–9,0 years), were selected for retrospective analysis. A median single dose of 15 grays (Gy; range, 11–20 Gy) was applied to the surface of the tumor.RESULTSAfter undergoing LINAC‐RS, 8 of 12 patients (67%) reported partial or complete subjective improvement, whereas complaints remained unchanged in 4 patients (33%). Neurologic status improved in 3 patients (25%) and remained unchanged in 8 patients (67%). Magnetic resonance images showed tumor shrinkage in 8 patients (67%) and no further progression in 4 patients (33%).CONCLUSIONSLINAC‐RS is an effective and safe therapy for patients with GJT and may be used as an alternative to surgical resection. Compared with fractionated radiotherapy, LINAC‐RS has some advantages. However, to clarify the question of long‐term tumor control, longer observation times are required. Cancer 2003;97:1093–98. © 2003 American Cancer Society.DOI 10.1002/cncr.11118

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Thông tin xuất bản

Cancer

Tập 97 Số 4

1093-1098

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