High incidence of ras gene mutation in intrahepatic cholangiocarcinoma

Cancer - Tập 69 Số 5 - Trang 1115-1118 - 1992
Minoru Tada1, Masao Omata2, Masao Ohio2
1First Dept. of Medicine, Chiba University School of Medicine, Japan.
2First Department of Medicine, Chiba University School of Medicine, Chiba, Japan

Tóm tắt

AbstractThe DNA sequences around codons 12, 13, and 61 of the ras gene were analyzed by polymerase chain reaction and direct sequencing in 18 intrahepatic cholangiocar‐cinomas. The ras gene mutations were found in 9 of 18 (50%): 6 in K‐ras codon 12, 1 in K‐ras codon 13, 1 in K‐ras codon 61, and 1 in N‐ras codon 12. The incidence of mutations was higher in the hilar type of intrahepatic cholan‐giocarcinomas, especially when these tumors were large. The incidence and spectrum of the mutations were almost the same as those reported in colon cancers, possibly indicating similar etiologic agent(s) in the carcinogenesis of both cancers.

Từ khóa


Tài liệu tham khảo

Hopkins NH, 1987, Molecular Biology of the Gene, 1058

Bos JL, 1989, Ras oncogenes in human cancer: A review, Cancer Res, 49, 4682

Tada M, 1990, Analysis of ras gene mutation in human malignant hepatic tumors by polymerase chain reaction and direct sequencing, Cancer Res, 50, 1121

10.1002/1097-0142(197701)39:1<232::AID-CNCR2820390137>3.0.CO;2-Y

10.1093/ajcp/90.3.309

10.1002/1097-0142(19900901)66:5<930::AID-CNCR2820660519>3.0.CO;2-W

Mizumoto R, 1987, Neoplasms of the Liver, 143

10.1056/NEJM198809013190901

10.1016/S0140-6736(71)90837-3

10.1038/342705a0

Thông tin
Thông tin xuất bản

Cancer

Tập 69 Số 5

1115-1118

Thông tin tác giả