Cancer and Metastasis Reviews
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Radiation cytogenetics: From chromosomes to single nucleotides and from metaphase cells to tissues
Cancer and Metastasis Reviews - Tập 23 - Trang 341-349 - 2004
This paper provides a broad overview of radiation cytogenetics that is divided into four sections. The first section provides a brief history of metaphase-based analyses for detecting and quantifying human exposure to ionizing radiation. The second section describes technologies for detecting cellular responses to radiation exposure other than DNA damage. The third section discusses molecular cyto......
Colorectal carcinoma in black and white race
Cancer and Metastasis Reviews - Tập 22 - Trang 67-82 - 2003
Worldwide, colorectal carcinoma (CRC) varies by race-ethnicity. The highest incidence occurs in whites of European descent. Rates in blacks of South Africa are much lower, but rise with migration to westernized countries, i.e. African Americans (blacks) in the US. In the US, CRC age-specific incidence rates increased dramatically with biologic aging for black and white men and women. For all ages,......
Non-glucose metabolism in cancer cells—is it all in the fat?
Cancer and Metastasis Reviews - Tập 31 - Trang 689-698 - 2012
Cancer biologists seem to have overlooked tumor metabolism in their research endeavors over the last 80 years of the last century, only to have “rediscovered Warburg” (Warburg et al. 1930; Warburg, Science 123(3191):309–314, 1956) within the first decade of the twenty-first century, as well as to suggest the importance of other, non-glucose-dependent, metabolic pathways such as such as fatty acid ......
Tackling tumor heterogeneity and phenotypic plasticity in cancer precision medicine: our experience and a literature review
Cancer and Metastasis Reviews - Tập 37 - Trang 655-663 - 2018
The predominant cause of cancer mortality is metastasis. The major impediment to cancer cure is the intrinsic or acquired resistance to currently available therapies. Cancer is heterogeneous at the genetic, epigenetic, and metabolic levels. And, while a molecular-targeted drug may be pathway-precise, it can still fail to achieve wholesome cancer-precise toxicity. In the current review, we discuss ......
Angiostatin and Angiostatin-related Proteins
Cancer and Metastasis Reviews - Tập 19 - Trang 97-107 - 2000
The study of angiogenesis, and the promise of angiogenesis inhibition as a means of cancer therapy, has dramatically accelerated in the last several years. The discovery and publication of angiostatin by O'Reilly and colleagues in Judah Folkman's lab in 1994 has greatly contributed to this progress. Angiostatin is a kringle-containing fragment of plasminogen, which is a potent inhibitor of angioge......
The role of fibroblasts in tumor behavior
Cancer and Metastasis Reviews - Tập 14 - Trang 339-350 - 1995
The prominent desmoplastic or stromal reaction seen in many invasive carcinomas suggests that stromal cells play a role in cancer pathogenesis. Investigations based on cell typing, using antibodies to cytoskeletal constituents, have revealed that most tumors contain various types of fibroblasts. Stromal cells with myofibroblastic differentiation features are the predominant cell type at the periph......
PRL PTPs: mediators and markers of cancer progression
Cancer and Metastasis Reviews - Tập 27 - Trang 231-252 - 2008
Aberrant protein tyrosine phosphorylation resulting from the altered activity of protein tyrosine phosphatases (PTPs) is increasingly being implicated in the genesis and progression of human cancer. Accumulating evidence indicates that the dysregulated expression of members of the phosphatase of regenerating liver (PRL) subgroup of PTPs is linked to these processes. Enhanced expression of the PRLs......
Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis
Cancer and Metastasis Reviews - Tập 29 Số 3 - Trang 483-502 - 2010
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