Cancer and Metastasis Reviews
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Carbohydrate-Recognition and Angiogenesis
Cancer and Metastasis Reviews - Tập 19 - Trang 51-57 - 2000
Angiogenesis is required for the continual growth of the tumor and provides a gateway for cells to escape the confines of the primary tumor. Angiogenic stimulus triggers a cascade of functional responses leading to local basement membrane dissolution, endothelial cell migration, proliferation and microvessel morphogenesis. In this commentary, we review the significance of carbohydrate-binding prot...... hiện toàn bộ
Splice variants of RAS—translational significance
Cancer and Metastasis Reviews - Tập 39 - Trang 1039-1049 - 2020
One of the mechanisms potentially explaining the discrepancy between the number of human genes and the functional complexity of organisms is generating alternative splice variants, an attribute of the vast majority of multi-exon genes. Members of the RAS family, such as NRAS, KRAS and HRAS, all of which are of significant importance in cancer biology, are no exception. The structural and functiona...... hiện toàn bộ
Recent advances in the detection of bone marrow micrometastases: A promising area for research or just another false hope? A review of the literature
Cancer and Metastasis Reviews - Tập 25 - Trang 507-519 - 2006
The presence of early disseminated tumor cells (DTC), otherwise termed micrometastases or minimal residual disease, in the bone marrow (BM), or other secondary compartments, such as the blood and the lymph nodes, is the main reason for recurrence of patients with early stage epithelial cancers after “curative” resection of the primary tumor. There is increasing evidence, that the detection of DTC ...... hiện toàn bộ
MicroRNA as a prognostic biomarker for survival in childhood acute lymphoblastic leukemia: a systematic review
Cancer and Metastasis Reviews - Tập 38 - Trang 771-782 - 2019
Recent studies suggest abnormal microRNA (miRNA) expression may have potential prognostic value in childhood acute lymphoblastic leukemia (ALL). In this systematic review, we searched different databases (PubMed, ASH, ASCO, and SIOP) for studies published from 2008 to 2018 that evaluated the prognostic impact of miRNAs in childhood ALL. We also used DIANA-miRPath v3.0 to further characterize the f...... hiện toàn bộ
The plasticity of pancreatic cancer stem cells: implications in therapeutic resistance
Cancer and Metastasis Reviews - Tập 40 - Trang 691-720 - 2021
The ever-growing perception of cancer stem cells (CSCs) as a plastic state rather than a hardwired defined entity has evolved our understanding of the functional and biological plasticity of these elusive components in malignancies. Pancreatic cancer (PC), based on its biological features and clinical evolution, is a prototypical example of a CSC-driven disease. Since the discovery of pancreatic C...... hiện toàn bộ
Orthotopic implantation is essential for the selection, growth and metastasis of human real cell cancer in nude mice
Cancer and Metastasis Reviews - Tập 9 - Trang 149-165 - 1990
Human neoplasms are heterogeneous for a variety of biological properties that include invasion and metastasis. The presence of a small subpopulation of cells with a highly metastatic phenotype has important clinical implications for diagnosis and therapy of cancer. For this reason, it is important to develop an animal model for the selection and isolation of metastatic variants from human neoplasm...... hiện toàn bộ
Epigenetic modulation of immunotherapy and implications in head and neck cancer
Cancer and Metastasis Reviews - Tập 40 - Trang 141-152 - 2021
Cancer progression is facilitated by distinct mechanisms developed by cancer cells to avoid immune recognition and clearance. The clinical application of immune checkpoint blockade (ICB), via monoclonal antibodies blocking PD-1/PD-L1 and CTLA4, has achieved promising durable therapeutic response in various cancer types, including recurrent and metastatic head and neck squamous cell carcinomas (HNS...... hiện toàn bộ
Why not treat human cancer with interleukin-1 blockade?
Cancer and Metastasis Reviews - Tập 29 - Trang 317-329 - 2010
The clinical successes of targeting angiogenesis provide a basis for trials of interleukin-1 (IL-1) blockade and particularly anti-IL-1β as an add-on therapy in human metastatic disease. In animal studies for over 20 years, IL-1 has been demonstrated to increase adherence of tumor cells to the endothelium in vitro, and administration of IL-1 to mice increases the number of metastatic colonies and ...... hiện toàn bộ
Peptide Growth Factors and Prostate Cancer: New Models, New Opportunities
Cancer and Metastasis Reviews - Tập 17 - Trang 317-324 - 1998
Prostate cancer is the leading form of newly diagnosed cancer cases in men in the United States. However, the molecular mechanisms contributing to the initiation, progression and ultimate development of metastatic and androgen independent disease are poorly understood. This is due in part to the difficulty in obtaining clinical samples representing early disease and the lack of animal models that ...... hiện toàn bộ
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