Cancer and Metastasis Reviews
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Clinical studies in head and neck cancer chemoprevention
Cancer and Metastasis Reviews - Tập 15 - Trang 113-118 - 1996
Secondary neoplasms represent a major threat for patients with head and neck cancer. The prevention of secondary neoplasms has been a major goal of head and neck cancer chemoprevention efforts. In order to help develop effective strategies, reversal of oral premalignancy has been used as a model for chemoprevention. There is now sufficient data to show the chemopreventive effect in premalignant le......
The Diet, Prostate Inflammation, and the Development of Prostate Cancer
Cancer and Metastasis Reviews - - 2002
Evidence that somatic inactivation of GSTP1, encoding the human π-class glutathione S-transferase, may initiate prostatic carcinogenesis is reviewed along with epidemiological evidence implicating several environment and lifestyle factors, including the diet and sexually transmitted diseases, as prostate cancer risk factors. An integrated model is presented featuring GSTP1 function as a 'caretaker......
PSC-833, a frontier in modulation of P-glycoprotein mediated multidrug resistance
Cancer and Metastasis Reviews - Tập 17 - Trang 163-168 - 1998
The expression of drug efflux mechanisms by cancer cells during chemotherapy leads to multidrug resistance (MDR) and constitutes a major obstacle in the effective treatment of cancer. The most widely characterized drug efflex pump is P-glycoprotein (P-gp) and efforts are being directed towards identifying agents that reverse P-gp mediated drug resistance. PSC-833 is a non-immunosuppressive cyclosp......
The p53 protein family and radiation sensitivity: Yes or no?
Cancer and Metastasis Reviews - Tập 23 - Trang 237-257 - 2004
The p53 tumor suppressor protein is a key mediator of an ATM-dependent DNA damage response cascade following cellular exposure to ionizing radiation. The p53-family members, p63 and p73, are highly similar to p53, yet are differentially activated by IR, UV and cis-platinum via ATM and c-abl/ATR signaling pathways. Loss of function of p53 can occur by mutation or degradation; giving rise to alterat......
Optimal use of anti-EGFR monoclonal antibodies for patients with advanced colorectal cancer: a meta-analysis
Cancer and Metastasis Reviews - Tập 36 - Trang 395-406 - 2017
This meta-analysis was performed to determine the optimal use of anti-EGFR mAb in the treatment of metastasized colorectal cancer (mCRC). Seventeen randomized clinical trials were included, all evaluating the added value of anti-EGFR mAb to standard treatment line in patients with KRAS wild-type mCRC. Hazard and odds ratios were pooled using a random effect model, weighted according to cohort size......
Designing antibodies for oncology
Cancer and Metastasis Reviews - Tập 24 - Trang 585-598 - 2005
The past five years have witnessed the emergence of monoclonal antibodies as important therapeutics for cancer treatment. Lower toxicity for antibodies versus small molecules, the potential for increased efficacy by conjugation to radioisotopes and cellular toxins, or the ability to exploit immune cell functions have led to clinical performances on par or superior to conventional drug therapies. T......
Estrogen, progesterone, and HER2/neu receptor discordance between primary and metastatic breast tumours—a review
Cancer and Metastasis Reviews - Tập 35 - Trang 427-437 - 2016
Discordance in estrogen (ER), progesterone (PR), and HER2/neu status between primary breast tumours and metastatic disease is well recognized. In this review, we highlight how receptor discordance between primary tumours and paired metastasis can help elucidate the mechanism of metastasis but can also effect patient management and the design of future trials. Discordance rates and ranges were avai......
Current and future trends in colorectal cancer screening
Cancer and Metastasis Reviews - Tập 23 - Trang 137-144 - 2004
Current modalities for colorectal cancer screening include fecal occult-blood testing, flexible sigmoido-scopy, colonoscopy, and double-contrast barium enema. Among these, colonoscopy is becoming the dominant modality, in light of its efficacy and continuing technical refinements. Emerging technologies, such as stool DNA tests and virtual colonoscopy, hold promise for the future but cannot be reco......
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