Cancer Medicine

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The combination of Hsp90 inhibitor 17AAG and heavy‐ion irradiation provides effective tumor control in human lung cancer cells
Cancer Medicine - Tập 4 Số 3 - Trang 426-436 - 2015
Hirokazu Hirakawa, Hiroshi Fujisawa, Aya Masaoka, Masafumi Noguchi, Ryoichi Hirayama, Momoko Takahashi, Akira Fujimori, Ryuichi Okayasu
AbstractHsp90 inhibitors have become well‐studied antitumor agents for their selective property against tumors versus normal cells. The combined treatment of Hsp90 inhibitor and conventional photon radiation also showed more effective tumor growth delay than radiation alone. However, little is known regarding the combined treatment of Hsp90 inhibitor and heavy‐ion ...... hiện toàn bộ
Effects of marital status on breast cancer survival by age, race, and hormone receptor status: A population‐based Study
Cancer Medicine - Tập 8 Số 10 - Trang 4906-4917 - 2019
Zhen Zhai, Fang Zhang, Yi Zheng, Linghui Zhou, Tian Tian, Shuai Lin, Yujiao Deng, Peng Xu, Qian Hao, Na Li, Pengtao Yang, Hongtao Li, Zhijun Dai
AbstractIntroductionIt remains unclear whether marital status could affect the breast cancer‐caused special survival (BCSS) of patients with breast cancer. Therefore, we sought to explore the influence of demographic and pathological factors on prognosis of patients with breast cancer.Mate...... hiện toàn bộ
Impact of meningioma surgery on use of antiepileptic, antidepressant, and sedative drugs: A Swedish nationwide matched cohort study
Cancer Medicine - Tập 10 Số 9 - Trang 2967-2977 - 2021
Erik Thurin, Isabelle Rydén, Thomas Skoglund, Anja Smits, Sasha Gulati, Göran Hesselager, Jiří Bártek, Roger Henriksson, Øyvind Salvesen, Asgeir Store Jakola
AbstractBackgroundMeningioma is the most common primary intracranial tumor and surgery is the main treatment modality. As death from lack of tumor control is rare, other outcome measures like anxiety, depression and post‐operative epilepsy are becoming increasingly relevant. In this nationwide registry‐based study we aimed to desc...... hiện toàn bộ
Demographic patterns of cutaneous T‐cell lymphoma incidence in Texas based on two different cancer registries
Cancer Medicine - Tập 4 Số 9 - Trang 1440-1447 - 2015
Ivan V. Litvinov, Michael T. Tetzlaff, Elham Rahme, Michelle Jennings, David R Risser, Pamela Gangar, Elena Netchiporouk, Linda Moreau, Victor G. Prieto, Denis Sasseville, Madeleine Duvic
AbstractCutaneous T‐cell lymohomas (CTCLs) are rare, but potentially devastating malignancies, with Mycosis fungoides and Sézary Syndrome being the most common. In our previous study, we identified and described regions of geographic clustering of CTCL... hiện toàn bộ
Resveratrol suppresses the growth and metastatic potential of cervical cancer by inhibiting STAT3Tyr705 phosphorylation
Cancer Medicine - Tập 9 Số 22 - Trang 8685-8700 - 2020
Xiaodong Sun, Qianqian Xu, Lian Zeng, Lixia Xie, Qiang Zhao, Hongxia Xu, Xuanbin Wang, Nan Jiang, Pan Fu, Ming Sang
AbstractAberrant signal transducer and activator of transcription 3 (STAT3) signaling promotes the initiation and progression of cancer in humans by either inhibiting apoptosis or inducing cell proliferation, angiogenesis, invasion, and metastasis. The role of resveratrol（RES）in inhibiting the STAT3 signaling pathway in vivo, particularly...... hiện toàn bộ
Comparison of PD‐L1 detection assays and corresponding significance in evaluation of diffuse large B‐cell lymphoma
Cancer Medicine - Tập 8 Số 8 - Trang 3831-3845 - 2019
Sixia Huang, Lin Nong, Li Liang, Yalin Zheng, Wei Wang, Jumei Liu, Dong Li, Xin Li, Ying Wang, Bo Zhang, Ting Li
AbstractThe expression of programmed cell death ligand 1 (PD‐L1) is a biomarker for immunotherapy, but approved detection method is absent in diffuse large B‐cell lymphoma (DLBCL). Here, we performed three methods including immunohistochemistry (IHC) (clone SP263 and SP142), RNAscope, and fluorescence in situ hybridization (FISH) to evaluate PD‐L1 status on a cohor...... hiện toàn bộ
BAY 87‐2243, a highly potent and selective inhibitor of hypoxia‐induced gene activation has antitumor activities by inhibition of mitochondrial complex I
Cancer Medicine - Tập 2 Số 5 - Trang 611-624 - 2013
Peter Ellinghaus, Iring Heisler, Kerstin Unterschemmann, Michael Haerter, Hartmut Beck, Susanne Greschat, Alexander Ehrmann, Holger Summer, Ingo Flamme, Felix Oehme, Karl‐Heinz Thierauch, Martin Michels, Holger Hess‐Stumpp, Karl Ziegelbauer
AbstractThe activation of the transcription factor hypoxia‐inducible factor‐1 (HIF‐1) plays an essential role in tumor development, tumor progression, and resistance to chemo‐ and radiotherapy. In order to identify compounds targeting the HIF ...... hiện toàn bộ
Musashi2 as a novel predictive biomarker for liver metastasis and poor prognosis in colorectal cancer
Cancer Medicine - Tập 5 Số 4 - Trang 623-630 - 2016
Zhen Zong, Taicheng Zhou, Liangjun Rao, Zhipeng Jiang, Yingru Li, Zehui Hou, Bin Yang, Fanghai Han, Shuang Chen
AbstractAberrant expression of musashi2 (MSI‐2) has been detected in several malignancies. However, its role in the progression of colorectal cancer (CRC) remains unknown. Our study was designed to investigate the expression and prognostic sig...... hiện toàn bộ
A retrospective study of venous thromboembolism in acute leukemia patients treated at the University of Texas MD Anderson Cancer Center
Cancer Medicine - Tập 4 Số 1 - Trang 27-35 - 2015
Khanh Dang Vu, Nhiem Luong, Julie C. Hubbard, Ali Zalpour, Stefan Faderl, Deborah A. Thomas, Daisy Yang, Hagop M. Kantarjian, Michael H. Kroll
AbstractThe purpose was to determine the incidence and prevalence of venous thromboembolism (VTE) in acute leukemia patients from our institution. We conducted a retrospective study on newly diagnosed acute leukemia patients who presented at our institution from November 1999 to May 2005. Descriptive sta...... hiện toàn bộ
Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer
Cancer Medicine - Tập 9 Số 10 - Trang 3574-3583 - 2020
Omar Elakad, Anna‐Maria Lois, Katja Schmitz, Sha Yao, Sara Hugo, Laura Lukat, Marc Hinterthaner, Bernhard C. Danner, Alexander von Hammerstein‐Equord, Kirsten Reuter‐Jessen, Hans‐Ulrich Schildhaus, Philipp Ströbel, Hanibal Bohnenberger
AbstractBackgroundTargeting fibroblast growth factor receptor 1 (FGFR1) is a potential treatment for squamous cell lung cancer (SQCLC). So far, treatment decision in clinical studies is based on gene amplification. However, only a minority of patients have shown durable response. Furthermore, former stud...... hiện toàn bộ
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