Cancer Medicine

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A Bayesian network meta‐analysis of the efficacy of targeted therapies and chemotherapy for treatment of triple‐negative breast cancer
Cancer Medicine - Tập 8 Số 1 - Trang 383-399 - 2019
Huihui Chen, Wei Lu, Yixin Zhang, Xuan Zhu, Jiaojiao Zhou, Yiding Chen
AbstractTriple‐negative breast cancer (TNBC) is a heterogeneous disease with poorer prognosis than other subtypes, yet effective therapies are still not available. We aimed to compare the efficacy of various targeted therapies with chemotherapy (CT) in TNBC patients using a network meta‐analysis. A systematic literature search was performed in PubMed, EMBASE, and the Cochrane Library. A total of 2... hiện toàn bộ
The combination of Hsp90 inhibitor 17AAG and heavy‐ion irradiation provides effective tumor control in human lung cancer cells
Cancer Medicine - Tập 4 Số 3 - Trang 426-436 - 2015
Hirokazu Hirakawa, Hiroshi Fujisawa, Aya Masaoka, Masafumi Noguchi, Ryoichi Hirayama, Momoko Takahashi, Akira Fujimori, Ryuichi Okayasu
AbstractHsp90 inhibitors have become well‐studied antitumor agents for their selective property against tumors versus normal cells. The combined treatment of Hsp90 inhibitor and conventional photon radiation also showed more effective tumor growth delay than radiation alone. However, little is known regarding the combined treatment of Hsp90 inhibitor and heavy‐ion irradiation. In this study, SQ5 h... hiện toàn bộ
Primary care physician characteristics associated with cancer screening: a retrospective cohort study in Ontario, Canada
Cancer Medicine - Tập 4 Số 2 - Trang 212-223 - 2015
Aisha Lofters, Ryan Ng, Rebecca Lobb
AbstractPrimary care physicians can serve as both facilitators and barriers to cancer screening, particularly for under‐screened groups such as immigrant patients. The objective of this study was to inform physician‐targeted interventions by identifying primary care physician characteristics associated with cancer screening for their eligible patients, for their eligible immigrant patients, and fo... hiện toàn bộ
A population study of screening history and diagnostic outcomes of women with invasive cervical cancer
Cancer Medicine - Tập 10 Số 12 - Trang 4127-4137 - 2021
Vicki B. Benard, J. Elizabeth Jackson, April Greek, Virginia Senkomago, Warner K. Huh, Cheryll C. Thomas, Lisa C. Richardson
AbstractBackgroundDespite advances to prevent and detect cervical cancer, national targets for screening have not been met in the United States. Previous studies suggested that approximately half of women who developed cervical cancer were not adequately screened. This study aimed to provide an updated examination of women's screening and diagnostic practices five years prior to an invasive cervic... hiện toàn bộ
Effects of marital status on breast cancer survival by age, race, and hormone receptor status: A population‐based Study
Cancer Medicine - Tập 8 Số 10 - Trang 4906-4917 - 2019
Zhen Zhai, Fang Zhang, Yi Zheng, Linghui Zhou, Tian Tian, Shuai Lin, Yujiao Deng, Peng Xu, Qian Hao, Na Li, Pengtao Yang, Hongtao Li, Zhijun Dai
AbstractIntroductionIt remains unclear whether marital status could affect the breast cancer‐caused special survival (BCSS) of patients with breast cancer. Therefore, we sought to explore the influence of demographic and pathological factors on prognosis of patients with breast cancer.Materials and methodsWe selected patients meeting the eligibility criteria from the Surveillance, Epidemiology, an... hiện toàn bộ
Impact of meningioma surgery on use of antiepileptic, antidepressant, and sedative drugs: A Swedish nationwide matched cohort study
Cancer Medicine - Tập 10 Số 9 - Trang 2967-2977 - 2021
Erik Thurin, Isabelle Rydén, Thomas Skoglund, Anja Smits, Sasha Gulati, Göran Hesselager, Jiří Bártek, Roger Henriksson, Øyvind Salvesen, Asgeir Store Jakola
AbstractBackgroundMeningioma is the most common primary intracranial tumor and surgery is the main treatment modality. As death from lack of tumor control is rare, other outcome measures like anxiety, depression and post‐operative epilepsy are becoming increasingly relevant. In this nationwide registry‐based study we aimed to describe the use of antiepileptic drugs (AED), antidepressants and sedat... hiện toàn bộ
Demographic patterns of cutaneous T‐cell lymphoma incidence in Texas based on two different cancer registries
Cancer Medicine - Tập 4 Số 9 - Trang 1440-1447 - 2015
Ivan V. Litvinov, Michael T. Tetzlaff, Elham Rahme, Michelle Jennings, David R Risser, Pamela Gangar, Elena Netchiporouk, Linda Moreau, Victor G. Prieto, Denis Sasseville, Madeleine Duvic
AbstractCutaneous T‐cell lymohomas (CTCLs) are rare, but potentially devastating malignancies, with Mycosis fungoides and Sézary Syndrome being the most common. In our previous study, we identified and described regions of geographic clustering of CTCL cases in Texas by analyzing ~1990 patients using two distinct cancer registries. In the current work, we describe in detail demographic patterns fo... hiện toàn bộ
Global loss of a nuclear lamina component, lamin A/C, and LINC complex components SUN1, SUN2, and nesprin‐2 in breast cancer
Cancer Medicine - Tập 4 Số 10 - Trang 1547-1557 - 2015
Ayaka Matsumoto, Miki Hieda, Yuhki Yokoyama, Yu Nishioka, Katsuhide Yoshidome, Masahiko Tsujimoto, Nariaki Matsuura∥
AbstractCancer cells exhibit a variety of features indicative of atypical nuclei. However, the molecular mechanisms underlying these phenomena remain to be elucidated. The linker of nucleoskeleton and cytoskeleton (LINC) complex, a nuclear envelope protein complex consisting mainly of the SUN and nesprin proteins, connects nuclear lamina and cytoskeletal filaments and helps to regulate the size an... hiện toàn bộ
Profiling of circulating tumor DNA in plasma of non‐small cell lung cancer patients, monitoring of epidermal growth factor receptor p.T790M mutated allelic fraction using beads, emulsion, amplification, and magnetics companion assay and evaluation in future application in mimicking circulating tumor cells
Cancer Medicine - Tập 8 Số 8 - Trang 3685-3697 - 2019
Jessica Garcia, Anne‐Sophie Wozny, Florence Geiguer, Aurélia Delherme, David Barthélémy, P. Merle, Claire Tissot, Frederick S. Jones, Chassidy Johnson, Xiaobin Xing, Zhenyu Xu, Daniel L. Edelstein, Marie Brevet, Pierre‐Jean Souquet, Claire Rodriguez‐Lafrasse, Léa Payen, S. Couraud
AbstractCell‐free plasma DNA (cfDNA) and mimicking circulating tumor cells (mCTCs) have demonstrated tremendous potential for molecular diagnosis of cancer and have been rapidly implemented in specific settings. However, widespread clinical adoption still faces some obstacles. The purpose was to compare the performance of a BEAMing (beads, emulsion, amplification, and magnetics) assay (OncoBEAM™‐e... hiện toàn bộ
Resveratrol suppresses the growth and metastatic potential of cervical cancer by inhibiting STAT3Tyr705 phosphorylation
Cancer Medicine - Tập 9 Số 22 - Trang 8685-8700 - 2020
Xiaodong Sun, Qianqian Xu, Lian Zeng, Lixia Xie, Qiang Zhao, Hongxia Xu, Xuanbin Wang, Nan Jiang, Pan Fu, Ming Sang
AbstractAberrant signal transducer and activator of transcription 3 (STAT3) signaling promotes the initiation and progression of cancer in humans by either inhibiting apoptosis or inducing cell proliferation, angiogenesis, invasion, and metastasis. The role of resveratrol（RES）in inhibiting the STAT3 signaling pathway in vivo, particularly in cervical cancer is still unknown. This study aims to inv... hiện toàn bộ
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