Demographic patterns of cutaneous T‐cell lymphoma incidence in Texas based on two different cancer registries

Cancer Medicine - Tập 4 Số 9 - Trang 1440-1447 - 2015
Ivan V. Litvinov1, Michael T. Tetzlaff2, Elham Rahme3, Michelle Jennings2, David R Risser4, Pamela Gangar5, Elena Netchiporouk1, Linda Moreau1, Victor G. Prieto2, Denis Sasseville1, Madeleine Duvic5
1Division of Dermatology, McGill University, Montreal, Quebec, Canada
2Section of Dermatopathology, Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas
3Division of Clinical Epidemiology, McGill University, Montreal, Quebec, Canada
4Cancer Epidemiology and Surveillance Branch Texas Cancer Registry Department of State Health Services Austin Texas
5Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Texas

Tóm tắt

AbstractCutaneous T‐cell lymohomas (CTCLs) are rare, but potentially devastating malignancies, with Mycosis fungoides and Sézary Syndrome being the most common. In our previous study, we identified and described regions of geographic clustering of CTCL cases in Texas by analyzing ~1990 patients using two distinct cancer registries. In the current work, we describe in detail demographic patterns for this malignancy in our study population and apply logistic regression models to analyze the incidence of CTCL by sex, race, age, and clinical stage at the time of diagnosis. Furthermore, using Fisher's exact test, we analyze changes in incidence over time in the identified Houston communities with unusually high CTCL incidence. While CTCL primarily affects Caucasian individuals >55 years old, we confirm that it presents at a younger age and with more advanced disease stages in African‐American and Hispanic individuals. Also, we demonstrate a significant increase in CTCL incidence over time in the identified communities. Spring, Katy, and Houston Memorial areas had high baseline rates. Furthermore, a statistically significant disease surge was observed in these areas after ~2005. This report supplements our initial study documenting the existence of geographic clustering of CTCL cases in Texas and in greater detail describes demographic trends for our patient population. The observed surge in CTCL incidence in the three identified communities further argues that this malignancy may be triggered by one or more external etiologic agents.

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Cancer Medicine

Tập 4 Số 9

1440-1447

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