New prognostic factors and scoring system for patients with skeletal metastasis Tập 3 Số 5 - Trang 1359-1367 - 2014
Hirohisa Katagiri, Rieko Okada, Tatsuya Takagi, M Takahashi, Hideki Murata, Hideyuki Harada, Tetsuo Nishimura, Hirofumi Asakura, Hirofumi Ogawa
AbstractThe aim of this study was to update a previous scoring system for patients with skeletal metastases, that was proposed by Katagiri et al. in 2005, by introducing a new factor (laboratory data) and analyzing a new patient cohort. Between January 2005 and January 2008, we treated 808 patients with symptomatic skeletal metastases. They were prospectively regis...... hiện toàn bộ Ovarian cancer: Current status and strategies for improving therapeutic outcomes Tập 8 Số 16 - Trang 7018-7031 - 2019
Ashwin Chandra, Cima Pius, Madiha Nabeel, Maya Nair, Jamboor K. Vishwanatha, Sarfraz Ahmad, Riyaz Basha
AbstractOf all the gynecologic tumors, ovarian cancer (OC) is known to be the deadliest. Advanced‐stages of OC are linked with high morbidity and low survival rates despite the immense amount of research in the field. Shortage of promising screening tools for early‐stage detection is one of the major challenges linked with the poor survival rate for patients with O...... hiện toàn bộ Using adaptive magnetic resonance image‐guided radiation therapy for treatment of inoperable pancreatic cancer Tập 8 Số 5 - Trang 2123-2132 - 2019
Soumon Rudra, Naomi Jiang, Stephen A. Rosenberg, Jeffrey R. Olsen, Michael Roach, Leping Wan, Lorraine Portelance, Eric A. Mellon, A. Bruynzeel, Frank J. Lagerwaard, M. Bassetti, Parag J. Parikh, Percy P. Lee
AbstractBackgroundAdaptive magnetic resonance imaging‐guided radiation therapy (MRgRT) can escalate dose to tumors while minimizing dose to normal tissue. We evaluated outcomes of inoperable pancreatic cancer patients treated using MRgRT with and without dose escalation.Methods... hiện toàn bộ Vessel co‐option in primary human tumors and metastases: an obstacle to effective anti‐angiogenic treatment? Tập 2 Số 4 - Trang 427-436 - 2013
Tom Dønnem, Jiangting Hu, Mary Ferguson, Omanma Adighibe, Cameron Snell, Adrian L. Harris, Kevin C. Gatter, Francesco Pezzella
AbstractAngiogenesis has been regarded as essential for tumor growth and progression. Studies of many human tumors, however, suggest that their microcirculation may be provided by nonsprouting vessels and that a variety of tumors can grow and metastasize without angiogenesis. Vessel co‐option, where tumor cells migrate along the preexisting vessels of the host orga...... hiện toàn bộ Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities Tập 8 Số 6 - Trang 3167-3181 - 2019
Mansour Sedighi, Abed Zahedi Bialvaei, Michael R. Hamblin, Elnaz Ohadi, Arezoo Asadi, Masoumeh Halajzadeh, Vahid Lohrasbi, Nima Mohammadzadeh, Taghi Amiriani, Marcela Krůtová, Abolfazl Amini, Ebrahim Kouhsari
AbstractSuccessful treatment of cancer remains a challenge, due to the unique pathophysiology of solid tumors, and the predictable emergence of resistance. Traditional methods for cancer therapy including radiotherapy, chemotherapy, and immunotherapy all have their own limitations. A novel approach is bacteriotherapy, either used alone, or in combination with conve...... hiện toàn bộ BAY 87‐2243, a highly potent and selective inhibitor of hypoxia‐induced gene activation has antitumor activities by inhibition of mitochondrial complex I Tập 2 Số 5 - Trang 611-624 - 2013
Peter Ellinghaus, Iring Heisler, Kerstin Unterschemmann, Michael Haerter, Hartmut Beck, Susanne Greschat, Alexander Ehrmann, Holger Summer, Ingo Flamme, Felix Oehme, Karl‐Heinz Thierauch, Martin Michels, Holger Hess‐Stumpp, Karl Ziegelbauer
AbstractThe activation of the transcription factor hypoxia‐inducible factor‐1 (HIF‐1) plays an essential role in tumor development, tumor progression, and resistance to chemo‐ and radiotherapy. In order to identify compounds targeting the HIF ...... hiện toàn bộ Global loss of a nuclear lamina component, lamin A/C, and LINC complex components SUN1, SUN2, and nesprin‐2 in breast cancer Tập 4 Số 10 - Trang 1547-1557 - 2015
Ayaka Matsumoto, Miki Hieda, Yuhki Yokoyama, Yu Nishioka, Katsuhide Yoshidome, Masahiko Tsujimoto, Nariaki Matsuura∥
AbstractCancer cells exhibit a variety of features indicative of atypical nuclei. However, the molecular mechanisms underlying these phenomena remain to be elucidated. The linker of nucleoskeleton and cytoskeleton (LINC) complex, a nuclear envelope protein complex consisting mainly of the ... hiện toàn bộ LncRNA PVT1 regulates prostate cancer cell growth by inducing the methylation of miR‐146a Tập 5 Số 12 - Trang 3512-3519 - 2016
Hongtao Liu, Lei Fang, Yu Cheng, Qing Sun
AbstractProstate cancer is the third most common causes of death from cancer in men. Our previous study demonstrated that lncRNA PVT1 was overexpressed and played an oncogenic role in the progression of prostate cancer. However, the molecular mechanism of modulating the prostate cancer tumorigenesis was still unknown. In this study, we aim to investigate the intera...... hiện toàn bộ The impact of genetic heterogeneity on biomarker development in kidney cancer assessed by multiregional sampling Tập 3 Số 6 - Trang 1485-1492 - 2014
Alexander Sankin, A. Ari Hakimi, Nina Mikkilineni, Irina Ostrovnaya, Mikhail Silk, Yupu Liang, Roy Mano, Michael Chevinsky, Robert J. Motzer, Stephen B. Solomon, Emily H. Cheng, Jeremy C. Durack, Jonathan Coleman, Paul Russo, James J. Hsieh
AbstractPrimary clear cell renal cell carcinoma (ccRCC) genetic heterogeneity may lead to an underestimation of the mutational burden detected from a single site evaluation. We sought to characterize the extent of clonal branching involving key tumor suppressor mutations in primary cc... hiện toàn bộ