Cancer Medicine
SCOPUS (2012-2025)SCIE-ISI
2045-7634
2045-7634
Anh Quốc
Cơ quản chủ quản: WILEY , John Wiley and Sons Ltd
Lĩnh vực:
Cancer ResearchRadiology, Nuclear Medicine and ImagingOncology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties
Tập 5 Số 10 - Trang 3007-3017 - 2016
AbstractNatural bicyclic sesquiterpenes, β‐caryophyllene (BCP) and
β‐caryophyllene oxide (BCPO), are present in a large number of plants worldwide.
Both BCP and BCPO (BCP(O)) possess significant anticancer activities, affecting
growth and proliferation of numerous cancer cells. Nevertheless, their
antineoplastic effects have hardly been investigated in vivo. In addition, both
compounds potentiate ...
New prognostic factors and scoring system for patients with skeletal metastasis
Tập 3 Số 5 - Trang 1359-1367 - 2014
AbstractThe aim of this study was to update a previous scoring system for
patients with skeletal metastases, that was proposed by Katagiri et al. in 2005,
by introducing a new factor (laboratory data) and analyzing a new patient
cohort. Between January 2005 and January 2008, we treated 808 patients with
symptomatic skeletal metastases. They were prospectively registered regardless
of their treatme...
Ovarian cancer: Current status and strategies for improving therapeutic outcomes
Tập 8 Số 16 - Trang 7018-7031 - 2019
AbstractOf all the gynecologic tumors, ovarian cancer (OC) is known to be the
deadliest. Advanced‐stages of OC are linked with high morbidity and low survival
rates despite the immense amount of research in the field. Shortage of promising
screening tools for early‐stage detection is one of the major challenges linked
with the poor survival rate for patients with OC. In OC, therapeutic management
...
Using adaptive magnetic resonance image‐guided radiation therapy for treatment of inoperable pancreatic cancer
Tập 8 Số 5 - Trang 2123-2132 - 2019
AbstractBackgroundAdaptive magnetic resonance imaging‐guided radiation therapy
(MRgRT) can escalate dose to tumors while minimizing dose to normal tissue. We
evaluated outcomes of inoperable pancreatic cancer patients treated using MRgRT
with and without dose escalation.MethodsWe reviewed 44 patients with inoperable
pancreatic cancer treated with MRgRT. Treatments included conventional
fractionati...
Vessel co‐option in primary human tumors and metastases: an obstacle to effective anti‐angiogenic treatment?
Tập 2 Số 4 - Trang 427-436 - 2013
AbstractAngiogenesis has been regarded as essential for tumor growth and
progression. Studies of many human tumors, however, suggest that their
microcirculation may be provided by nonsprouting vessels and that a variety of
tumors can grow and metastasize without angiogenesis. Vessel co‐option, where
tumor cells migrate along the preexisting vessels of the host organ, is regarded
as an alternative ...
Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities
Tập 8 Số 6 - Trang 3167-3181 - 2019
AbstractSuccessful treatment of cancer remains a challenge, due to the unique
pathophysiology of solid tumors, and the predictable emergence of resistance.
Traditional methods for cancer therapy including radiotherapy, chemotherapy, and
immunotherapy all have their own limitations. A novel approach is
bacteriotherapy, either used alone, or in combination with conventional methods,
has shown a posi...
Tập 2 Số 5 - Trang 611-624 - 2013
AbstractThe activation of the transcription factor hypoxia‐inducible factor‐1
(HIF‐1) plays an essential role in tumor development, tumor progression, and
resistance to chemo‐ and radiotherapy. In order to identify compounds targeting
the HIF pathway, a small molecule library was screened using a luciferase‐driven
HIF‐1 reporter cell line under hypoxia. The high‐throughput screening led to the
ide...
Global loss of a nuclear lamina component, lamin A/C, and LINC complex components SUN 1, SUN 2, and nesprin‐2 in breast cancer
Tập 4 Số 10 - Trang 1547-1557 - 2015
AbstractCancer cells exhibit a variety of features indicative of atypical
nuclei. However, the molecular mechanisms underlying these phenomena remain to
be elucidated. The linker of nucleoskeleton and cytoskeleton (LINC) complex, a
nuclear envelope protein complex consisting mainly of the SUN and nesprin
proteins, connects nuclear lamina and cytoskeletal filaments and helps to
regulate the size an...
LncRNA PVT1 regulates prostate cancer cell growth by inducing the methylation of miR‐146a
Tập 5 Số 12 - Trang 3512-3519 - 2016
AbstractProstate cancer is the third most common causes of death from cancer in
men. Our previous study demonstrated that lncRNA PVT1 was overexpressed and
played an oncogenic role in the progression of prostate cancer. However, the
molecular mechanism of modulating the prostate cancer tumorigenesis was still
unknown. In this study, we aim to investigate the interaction between PVT1 and
miR‐146a i...
The impact of genetic heterogeneity on biomarker development in kidney cancer assessed by multiregional sampling
Tập 3 Số 6 - Trang 1485-1492 - 2014
AbstractPrimary clear cell renal cell carcinoma (ccRCC) genetic heterogeneity
may lead to an underestimation of the mutational burden detected from a single
site evaluation. We sought to characterize the extent of clonal branching
involving key tumor suppressor mutations in primary ccRCC and determine if
genetic heterogeneity could limit the mutation profiling from a single region
assessment. Ex v...